Simone B. Duss
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View article: A novel murine model of stress-induced cardiomyopathy achieved by chemogenetic stimulation of the locus coeruleus-norepinephrine system
A novel murine model of stress-induced cardiomyopathy achieved by chemogenetic stimulation of the locus coeruleus-norepinephrine system Open
Background Takotsubo syndrome (TTS) is a stress-induced acute cardiomyopathy characterized by transient left ventricular (LV) dysfunction without obstructive coronary artery disease. TTS is often underdiagnosed and undertreated and typical…
Early sleep apnea treatment in stroke (<span>eSATIS</span>) – a multicentre, randomised controlled, rater‐blinded, clinical trial: The association of post‐stroke cognition with sleep‐disordered breathing and its treatment Open
Summary Sleep‐disordered breathing (SDB) is linked to cognitive dysfunction. Although SDB is common in stroke patients, the impact of SDB and its early treatment on cognitive functioning after stroke remains poorly investigated. Therefore,…
Clinical effectiveness of internet-based cognitive behavioral therapy for insomnia in routine secondary care: results of a randomized controlled trial Open
Introduction Delivering cognitive behavioral therapy for insomnia over the internet bears the advantage of accessibility and uptake to many patients suffering from chronic insomnia. In the current study, we aimed to investigate the effecti…
The Swiss Sleep House Bern—A New Approach to Sleep Medicine Open
Sleep is essential for health, well-being, creativity, and productivity. Sleep loss and sleep–wake circadian disorders (SWCDs) affect at least one in three individuals but are underdiagnosed and undertreated for different reasons: First, t…
Impact of Comorbid Sleep-Disordered Breathing and Atrial Fibrillation on the Long-Term Outcome After Ischemic Stroke Open
BACKGROUND: Sleep-disordered breathing (SDB) and atrial fibrillation (AF) are highly prevalent in patients with stroke and are recognized as independent risk factors for stroke. Little is known about the impact of comorbid SDB and AF on lo…
Blood pressure variability, nocturnal heart rate variability and endothelial function predict recurrent cerebro-cardiovascular events following ischemic stroke Open
Introduction Cardiovascular parameters characterizing blood pressure (BP), heart rate (HR), endothelial function and arterial stiffness predict cerebro-cardiovascular events (CCVE) in the general population. Considering the paucity of data…
SLEEPexpert+: Blending Internet-Based Cognitive Behavioral Therapy for Insomnia with In-Person Psychotherapy—A Feasibility Study in Routine Care Open
Insomnia is characterized by frequent and persistent difficulties initiating and maintaining sleep, along with impaired daytime functioning. Blended treatments are increasingly popular for treating psychological disorders such as depressio…
View article: Counselling for Chronic Insomnia in Swiss Pharmacies: A Survey Study Based on Case Vignettes
Counselling for Chronic Insomnia in Swiss Pharmacies: A Survey Study Based on Case Vignettes Open
(1) Introduction: Chronic insomnia (CI) reduces quality of life and may trigger depression and cardiovascular diseases. The European Sleep Research Society recommends cognitive behavioural therapy (CBT-I) as the first-line treatment. Becau…
Multiple sleep–wake disturbances after stroke predict an increased risk of cardio‐cerebrovascular events or death: A prospective cohort study Open
Background and purpose Contradictory evidence on the impact of single sleep‐wake‐disturbances (SWD), such as sleep‐disorderd breating (SDB) or insomnia, in patients with stroke, on the risk of subsequent cardio‐ and cerebrovascular events …
Guided Internet-Based Cognitive Behavioral Therapy for Insomnia: Prognostic and Treatment-Predictive Factors Open
Understanding which factors predict the outcome of internet-based cognitive behavioral therapy for insomnia (iCBT-I) may help to tailor this intervention to the patient’s needs. We have conducted a secondary analysis of a randomized, contr…
View article: Frequency and evolution of sleep-wake disturbances after ischemic stroke: A 2-year prospective study of 437 patients
Frequency and evolution of sleep-wake disturbances after ischemic stroke: A 2-year prospective study of 437 patients Open
This study documents a high frequency of SDB, insomnia, fatigue and a prolonged sleep duration after stroke/TIA, which can persist for years. Considering the negative effects of SWD on physical, brain and mental health these data suggest t…
Treating insomnia in Swiss primary care practices: A survey study based on case vignettes Open
Guidelines recommend cognitive behavioural therapy for insomnia (CBT‐I) as first‐line treatment for chronic insomnia, but it is not clear how many primary care physicians (PCPs) in Switzerland prescribe this treatment. We created a survey …
Effectiveness and cost-effectiveness of internet-based cognitive behavioral therapy for insomnia in clinical settings (study protocol) Open
Background: Internet-delivered cognitive-behavior treatment for insomnia (iCBT-I) has the potential to fill the gap created by the discrepancy between insomnia cases and number of trained professionals. Although the effectiveness of this m…
Effectiveness and Cost-Effectiveness of Internet-Based Cognitive Behavioral Therapy for Insomnia in Clinical Settings Open
BACKGROUND: Internet-delivered cognitive-behavior treatment for insomnia (iCBT-I) has the potential to fill the gap created by the discrepancy between insomnia cases and number of trained professionals. Although the effectiveness of this m…
Prevalence and management of chronic insomnia in Swiss primary care: Cross‐sectional data from the “Sentinella” practice‐based research network Open
We investigated the prevalence and treatment of patients with chronic insomnia presenting to Swiss primary care physicians (PCPs) part of “Sentinella”, a nationwide practice‐based research network. Each PCP consecutively asked 40 patients …
Sleep-disordered breathing and stroke: chicken or egg? Open
The bidirectional interaction between sleep-disordered breathing (SDB) and stroke has been the subject of many studies. On the one hand, different forms of SDB, and especially obstructive sleep apnea, increase the risk of stroke either dir…
View article: Rapid eye movements sleep as a predictor of functional outcome after stroke: a translational study
Rapid eye movements sleep as a predictor of functional outcome after stroke: a translational study Open
http://clinicaltrials.gov. Unique identifier: NCT01097967.
The role of sleep in recovery following ischemic stroke: A review of human and animal data Open
Despite advancements in understanding the pathophysiology of stroke and the state of the art in acute management of afflicted patients as well as in subsequent neurorehabilitation training, stroke remains the most common neurological cause…