Simone Baltrusch
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View article: Shape, membrane morphology, and morphodynamic response of metabolically active human mitochondria revealed by scanning ion conductance microscopy
Shape, membrane morphology, and morphodynamic response of metabolically active human mitochondria revealed by scanning ion conductance microscopy Open
Mitochondrial network dynamics play a key role in enabling cells to adapt to environmental changes. Fusion and fission of mitochondria, as well as their contact with other organelles, are central processes. Consequently, the outer membrane…
View article: Effects of coding variants in the glucokinase regulatory protein gene on hepatic glucose and triglyceride metabolism suggest a gene regulatory function of glucokinase
Effects of coding variants in the glucokinase regulatory protein gene on hepatic glucose and triglyceride metabolism suggest a gene regulatory function of glucokinase Open
Our results, supported by a modeling approach, suggest that GKRP-mediated nuclear localization of GCK has a function in liver metabolism beyond GCK inhibition and sequestration. This needs further elucidation given that GKRP disruptors hav…
View article: Automated in‐depth fiber and nuclei typing in cross‐sectional muscle images can pave the way to a better understanding of skeletal muscle diseases
Automated in‐depth fiber and nuclei typing in cross‐sectional muscle images can pave the way to a better understanding of skeletal muscle diseases Open
In this issue of Acta Physiologica, Lundquist et al.1 present a new platform for automated image data analysis of skeletal muscle samples. Immunohistochemical analysis can be used to visualize the fiber type composition of different skelet…
View article: Free Article from Systems Biologists Seek Fuller Integration of Systems Biology Approaches in New Cancer Research Programs
Free Article from Systems Biologists Seek Fuller Integration of Systems Biology Approaches in New Cancer Research Programs Open
Free Article from Systems Biologists Seek Fuller Integration of Systems Biology Approaches in New Cancer Research Programs
View article: Data from Systems Biologists Seek Fuller Integration of Systems Biology Approaches in New Cancer Research Programs
Data from Systems Biologists Seek Fuller Integration of Systems Biology Approaches in New Cancer Research Programs Open
Systems biology takes an interdisciplinary approach to the systematic study of complex interactions in biological systems. This approach seeks to decipher the emergent behaviors of complex systems rather than focusing only on their constit…
View article: Free Article from Systems Biologists Seek Fuller Integration of Systems Biology Approaches in New Cancer Research Programs
Free Article from Systems Biologists Seek Fuller Integration of Systems Biology Approaches in New Cancer Research Programs Open
Free Article from Systems Biologists Seek Fuller Integration of Systems Biology Approaches in New Cancer Research Programs
View article: Data from Systems Biologists Seek Fuller Integration of Systems Biology Approaches in New Cancer Research Programs
Data from Systems Biologists Seek Fuller Integration of Systems Biology Approaches in New Cancer Research Programs Open
Systems biology takes an interdisciplinary approach to the systematic study of complex interactions in biological systems. This approach seeks to decipher the emergent behaviors of complex systems rather than focusing only on their constit…
View article: The Role of Neurotropic B Vitamins in Nerve Regeneration
The Role of Neurotropic B Vitamins in Nerve Regeneration Open
Damage and regeneration naturally occur in the peripheral nervous system. The neurotropic B vitamins thiamine (B1), pyridoxine (B6), and cobalamin (B12) are key players, which maintain the neuronal viability in different ways. Firstly, the…
View article: Collagen Remodeling Plays a Pivotal Role in Endothelial Corneal Dystrophies
Collagen Remodeling Plays a Pivotal Role in Endothelial Corneal Dystrophies Open
The collagen structure of the DM and its adaptive remodeling in endothelial corneal dystrophies has been characterized for the first time here and will facilitate individual therapeutic approaches.
View article: MiD51 Is Important for Maintaining Mitochondrial Health in Pancreatic Islet and MIN6 Cells
MiD51 Is Important for Maintaining Mitochondrial Health in Pancreatic Islet and MIN6 Cells Open
Background: Mitochondrial dynamics are important for glucose-stimulated insulin secretion in pancreatic beta cells. The mitochondrial elongation factor MiD51 has been proposed to act as an anchor that recruits Drp1 from the cytosol to the …
View article: Combination of mitochondrial tRNA and OXPHOS mutation reduces lifespan and physical condition in aged mice
Combination of mitochondrial tRNA and OXPHOS mutation reduces lifespan and physical condition in aged mice Open
Mutations in the mitochondrial DNA (mtDNA) are widely known to impact on lifespan and tissue integrity. For example, more than 250 pathogenic mtDNA mutations are known, many of which lead to neurological symptoms. In addition, major neurod…
View article: Polymorphism in Murine mtATP8 Gene Correlates with Decreased Reactive Oxygen Species in Aging Hematopoietic Cells
Polymorphism in Murine mtATP8 Gene Correlates with Decreased Reactive Oxygen Species in Aging Hematopoietic Cells Open
The investigated polymorphism is associated with decreased ROS levels in aged hematopoietic cells but does not significantly influence hematopoiesis itself.
View article: Polymorphisms of the murine mitochondrial <i>ND4</i>, <i>CYTB</i> and <i>COX3</i> genes impact hematopoiesis during aging
Polymorphisms of the murine mitochondrial <i>ND4</i>, <i>CYTB</i> and <i>COX3</i> genes impact hematopoiesis during aging Open
During aging, mitochondrial DNA (mtDNA) can accumulate mutations leading to increasing levels of reactive oxygen species (ROS). Increased ROS were described to activate formerly quiescent hematopoietic stem cells (HSC). Mutations in mtDNA …
View article: Early detection of diabetic neuropathy by investigating CNFL and IENFD in thy1-YFP mice
Early detection of diabetic neuropathy by investigating CNFL and IENFD in thy1-YFP mice Open
Small fiber neuropathy is one of the most common and painful long-term complications of diabetes mellitus. Examination of the sub-basal corneal nerve plexus is a promising surrogate marker of diabetic neuropathy. To investigate the efficac…
View article: Precise expression of Fis1 is important for glucose responsiveness of beta cells
Precise expression of Fis1 is important for glucose responsiveness of beta cells Open
Mitochondrial network functionality is vital for glucose-stimulated insulin secretion in pancreatic beta cells. Altered mitochondrial dynamics in pancreatic beta cells are thought to trigger the development of type 2 diabetes mellitus. Fis…