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View article: Effect of Acute Hypoxia Exposure on the Availability of A<sub>1</sub>Adenosine Receptors and Perfusion in the Human Brain
Effect of Acute Hypoxia Exposure on the Availability of A<sub>1</sub>Adenosine Receptors and Perfusion in the Human Brain Open
In animal studies it has been observed that the inhibitory neuromodulator adenosine is released into the cerebral interstitial space during hypoxic challenges. Adenosine's actions on the A1 adenosine receptor (A1AR) protect the brain from …
View article: Explainable artificial intelligence identifies an AQP4 polymorphism-based risk score associated with brain amyloid burden
Explainable artificial intelligence identifies an AQP4 polymorphism-based risk score associated with brain amyloid burden Open
Aquaporin-4 (AQP4) is hypothesized to be a component of the glymphatic system, a pathway for removing brain interstitial solutes like amyloid-β (Aβ). Evidence exists that genetic variation of AQP4 impacts Aβ clearance, clinical outcome in …
View article: Dynamic neuroreceptor positron emission tomography in non-anesthetized rats using point source based motion correction: A feasibility study with [<sup>11</sup>C]ABP688
Dynamic neuroreceptor positron emission tomography in non-anesthetized rats using point source based motion correction: A feasibility study with [<sup>11</sup>C]ABP688 Open
To prevent motion artifacts in small animal positron emission tomography (PET), animals are routinely scanned under anesthesia or physical restraint. Both may potentially alter metabolism and neurochemistry. This study investigates the fea…
View article: Explainable artificial intelligence identifies an AQP4 polymorphism-based risk score associated with brain amyloid burden
Explainable artificial intelligence identifies an AQP4 polymorphism-based risk score associated with brain amyloid burden Open
Aquaporin-4 (AQP4) is an integral component of the glymphatic system, today considered a crucial pathway for removing brain interstitial solutes like amyloid-β (Aβ). Evidence exists that genetic variation of AQP4 impacts Aβ clearance, clin…
View article: A genetic variation in the adenosine A2A receptor gene contributes to variability in oscillatory alpha power in wake and sleep EEG and A1 adenosine receptor availability in the human brain
A genetic variation in the adenosine A2A receptor gene contributes to variability in oscillatory alpha power in wake and sleep EEG and A1 adenosine receptor availability in the human brain Open
The EEG alpha rhythm (∼ 8-13 Hz) is one of the most salient human brain activity rhythms, modulated by the level of attention and vigilance and related to cerebral energy metabolism. Spectral power in the alpha range in wakefulness and sle…
View article: A genetic variation in the adenosine A2A receptor gene contributes to variability in oscillatory alpha power in wake and sleep EEG and A<sub>1</sub>adenosine receptor availability in the human brain
A genetic variation in the adenosine A2A receptor gene contributes to variability in oscillatory alpha power in wake and sleep EEG and A<sub>1</sub>adenosine receptor availability in the human brain Open
The EEG alpha rhythm (8-13 Hz) is one of the most salient human brain activity rhythms. Spectral power in the alpha range in wakefulness and sleep varies among individuals based on genetical predisposition, yet knowledge about the underlyi…
View article: Total Sleep Deprivation Increases Brain Age Prediction Reversibly in Multisite Samples of Young Healthy Adults
Total Sleep Deprivation Increases Brain Age Prediction Reversibly in Multisite Samples of Young Healthy Adults Open
Sleep loss pervasively affects the human brain at multiple levels. Age-related changes in several sleep characteristics indicate that reduced sleep quality is a frequent characteristic of aging. Conversely, sleep disruption may accelerate …
View article: Comparison of the Amyloid Load in the Brains of Two Transgenic Alzheimer’s Disease Mouse Models Quantified by Florbetaben Positron Emission Tomography
Comparison of the Amyloid Load in the Brains of Two Transgenic Alzheimer’s Disease Mouse Models Quantified by Florbetaben Positron Emission Tomography Open
Alzheimer’s disease (AD) is characterized by formation of amyloid plaques and neurofibrillary tangles in the brain, which can be mimicked by transgenic mouse models. Here, we report on the characterization of amyloid load in the brains of …
View article: Radiological characteristics of a new experimental rubber elastomeric polymer used in three-dimensional printing with different infill densities and patterns
Radiological characteristics of a new experimental rubber elastomeric polymer used in three-dimensional printing with different infill densities and patterns Open
The objective of this study was to investigate new 3D printable materials, namely PORO-LAY series in both solid and flexible forms, on behalf of their radiological properties by measuring their Hounsfield units (HUs) values at varying infi…
View article: T <sub>1</sub>-mapping and dielectric properties evaluation of a 3D printable rubber-elastomeric polymer as tissue mimicking materials for MRI phantoms
T <sub>1</sub>-mapping and dielectric properties evaluation of a 3D printable rubber-elastomeric polymer as tissue mimicking materials for MRI phantoms Open
In this study, a new series of 3D printable rubber-elastomeric polymer called PORO-LAY materials have been investigated regarding their suitability to serve as tissue mimicking materials (TMMs) for MRI phantoms. PORO-LAY materials have bee…
View article: Image-Derived Input Functions for Quantification of A1 Adenosine Receptors Availability in Mice Brains Using PET and [18F]CPFPX
Image-Derived Input Functions for Quantification of A1 Adenosine Receptors Availability in Mice Brains Using PET and [18F]CPFPX Open
The proposed study provides evidence that IDIF with VOI over heart can replace AIF effectively for quantification of A1ARs using PET and [18F]CPFPX in mice brains.
View article: Image Quality assessment for Awake Animal Brain PET
Image Quality assessment for Awake Animal Brain PET Open
A restrictive issue for small-animal positron emission tomography (PET) imaging is the fact that animals have to be either anaesthetized or physically restrained to prevent them from moving during the imaging procedure. Tracking the motion…
View article: Phosphocreatine Levels in the Left Thalamus Decline during Wakefulness and Increase after a Nap
Phosphocreatine Levels in the Left Thalamus Decline during Wakefulness and Increase after a Nap Open
Scientists have hypothesized that the availability of phosphocreatine (PCr) and its ratio to inorganic phosphate (Pi) in cerebral tissue form a substrate of wakefulness. It follows then, according to this hypothesis, that the exhaustion of…
View article: Circadian variation of metabotropic glutamate receptor 5 availability in the rat brain
Circadian variation of metabotropic glutamate receptor 5 availability in the rat brain Open
Summary The metabotrophic subtype 5 glutamate receptor ( mG luR5) plays a critical role in synaptic plasticity besides its involvement in numerous neurological disorders, such as depression. As mG luR5 availability in humans is altered in …