Simone Bonetti
YOU?
Author Swipe
View article: Redefine tumor spheroids heterogeneity via PCA-coupled biophysical characterization
Redefine tumor spheroids heterogeneity via PCA-coupled biophysical characterization Open
Spheroids, a part of 3D cell culture systems, are crucial models for bridging in-vitro and in-human studies. However, achieving reliable standardization remains difficult, even when comparing spheroids of similar diameters. The challenge a…
View article: A 3D-Bioprinted Dermal-Like Scaffold Incorporating Fibroblasts and DRG Neurons to investigate Peripheral Nerve Regeneration
A 3D-Bioprinted Dermal-Like Scaffold Incorporating Fibroblasts and DRG Neurons to investigate Peripheral Nerve Regeneration Open
Peripheral nervous system (PNS) regeneration is a rapidly advancing field with critical implications for addressing sensory impairments and neuropathic conditions. Dorsal root ganglion (DRG) neurons, essential for sensory transmission, exh…
View article: A 3D-Bioprinted Dermal-Like Scaffold Incorporating Fibroblasts and DRG Neurons to investigate Peripheral Nerve Regeneration
A 3D-Bioprinted Dermal-Like Scaffold Incorporating Fibroblasts and DRG Neurons to investigate Peripheral Nerve Regeneration Open
Peripheral nervous system (PNS) regeneration is a rapidly advancing field with critical implications for addressing sensory impairments and neuropathic conditions. Dorsal root ganglion (DRG) neurons, essential for sensory transmission, exh…
View article: A 3D-bioprinted dermal-like scaffold incorporating fibroblasts and DRG neurons to investigate peripheral nerve regeneration
A 3D-bioprinted dermal-like scaffold incorporating fibroblasts and DRG neurons to investigate peripheral nerve regeneration Open
A 3D-bioprinted scaffold containing fibroblasts and DRG neurons was developed to investigate PNS regeneration. This model supports neurite outgrowth and provides a platform for personalized therapies targeting neuropathic pain and sensory …
View article: Role of crystal orientation in attosecond photoinjection dynamics of germanium
Role of crystal orientation in attosecond photoinjection dynamics of germanium Open
Understanding photoinjection in semiconductors—a fundamental physical process—represents the first step toward devising new opto-electronic devices, capable of operating on unprecedented time scales. Fostered by the development of few-femt…
View article: The role of crystal orientation in attosecond photoinjection dynamics in germanium
The role of crystal orientation in attosecond photoinjection dynamics in germanium Open
Ultrashort light pulses can be used to manipulate electronic and optical properties of solids at extreme temporal scales, paving the way to the study of ultrafast electron dynamics. In recent years, attosecond-based spectroscopic technique…
View article: Human Astrocyte Spheroids as Suitable In Vitro Screening Model to Evaluate Synthetic Cannabinoid MAM2201-Induced Effects on CNS
Human Astrocyte Spheroids as Suitable In Vitro Screening Model to Evaluate Synthetic Cannabinoid MAM2201-Induced Effects on CNS Open
There is growing concern about the consumption of synthetic cannabinoids (SCs), one of the largest groups of new psychoactive substances, its consequence on human health (general population and workers), and the continuous placing of new S…
View article: A viability study of 3D tumor spheroids after their mass-density characterization via an innovative flow-based biophysical method
A viability study of 3D tumor spheroids after their mass-density characterization via an innovative flow-based biophysical method Open
The simple measurement of mass density, size and weight of sphere-like 3D cell models has been recently enabled by a specifically conceived flow-based method. Here we demonstrate that such technique also allows the post-analysis collection…
View article: A new method for the study of biophysical and morphological parameters in 3D cell cultures: Evaluation in LoVo spheroids treated with crizotinib
A new method for the study of biophysical and morphological parameters in 3D cell cultures: Evaluation in LoVo spheroids treated with crizotinib Open
Three-dimensional (3D) culture systems like tumor spheroids represent useful in vitro models for drug screening and more broadly for cancer biology research, but the generation of uniform populations of spheroids remains challenging. The p…
View article: Physical Characterization of Colorectal Cancer Spheroids and Evaluation of NK Cell Infiltration Through a Flow-Based Analysis
Physical Characterization of Colorectal Cancer Spheroids and Evaluation of NK Cell Infiltration Through a Flow-Based Analysis Open
To improve pathogenetic studies in cancer development and reliable preclinical testing of anti-cancer treatments, three-dimensional (3D) cultures, including spheroids, have been widely recognized as more physiologically relevant in vitro m…
View article: A Reliable Flow-Based Method for the Accurate Measure of Mass Density, Size and Weight of Live 3D Tumor Spheroids
A Reliable Flow-Based Method for the Accurate Measure of Mass Density, Size and Weight of Live 3D Tumor Spheroids Open
Gathering precise information on mass density, size and weight of cells or cell aggregates, is crucial for applications in many biomedical fields with a specific focus on cancer research. Although few technical solutions have been presente…
View article: Electrical Stimulation by an Organic Transistor Architecture Induces Calcium Signaling in Nonexcitable Brain Cells
Electrical Stimulation by an Organic Transistor Architecture Induces Calcium Signaling in Nonexcitable Brain Cells Open
Organic bioelectronics have a huge potential to generate interfaces and devices for the study of brain functions and for the therapy of brain pathologies. In this context, increasing efforts are needed to develop technologies for monitorin…
View article: Towards hydrophobic carminic acid derivatives and their incorporation in polyacrylates
Towards hydrophobic carminic acid derivatives and their incorporation in polyacrylates Open
Carminic acid, a natural hydrophilic dye extensively used in the food and cosmetic industries, is converted in hydrophobic dyes by acetylation or pivaloylation. These derivatives are successfully used as biocolourants for rubber objects. I…
View article: Toward hydrophobic carminic acid derivatives and their inclusion in polyacrylates.
Toward hydrophobic carminic acid derivatives and their inclusion in polyacrylates. Open
Carminic acid, a natural hydrophilic dye extensively used in food and cosmetic industries, is converted in hydrophobic dyes by acetylation or pivaloylation. These derivatives are successfully used as biocolorants for polyacrylate objects. …
View article: Supplementary material from "Towards hydrophobic carminic acid derivatives and their incorporation in polyacrylates"
Supplementary material from "Towards hydrophobic carminic acid derivatives and their incorporation in polyacrylates" Open
Carminic acid, a natural hydrophilic dye extensively used in food and cosmetic industries, is converted in hydrophobic dyes by acetylation or pivaloylation. These derivatives are successfully used as biocolourants for rubber objects. Spect…
View article: A Nanoscale Interface Promoting Molecular and Functional Differentiation of Neural Cells
A Nanoscale Interface Promoting Molecular and Functional Differentiation of Neural Cells Open
Potassium channels and aquaporins expressed by astrocytes are key players in the maintenance of cerebral homeostasis and in brain pathophysiologies. One major challenge in the study of astrocyte membrane channels in vitro, is that their ex…
View article: Polymer Nanoparticles: A New Technological Platform for Emerging Applications
Polymer Nanoparticles: A New Technological Platform for Emerging Applications Open
Polymer-based nanoparticles tackle many different fields, from extrinsic self-healing materials to cosmetics, from electronics to nanophotonics. This is mainly due to the wide range of applications and market needs that polymers have been …
View article: Effect of different fabrication methods on the chemo-physical properties of silk fibroin films and on their interaction with neural cells
Effect of different fabrication methods on the chemo-physical properties of silk fibroin films and on their interaction with neural cells Open
In this study, we investigated the influence of processing methods on the chemo-physical properties of silk fibroin (SF) film and on their interaction with neural cells.