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View article: Application of computer vision for automated detection of different lesions in pig lungs: An exploratory study
Application of computer vision for automated detection of different lesions in pig lungs: An exploratory study Open
Accurate classification of lung lesions at necropsy is crucial for guiding the diagnostic process and ensuring effective management of porcine respiratory diseases. Post-mortem inspection of the lungs during slaughter also provides valuabl…
View article: Onvansertib-Based Second-Line Therapies in Combination with Gemcitabine and Carboplatin in Patient-Derived Platinum-Resistant Ovarian Carcinomas
Onvansertib-Based Second-Line Therapies in Combination with Gemcitabine and Carboplatin in Patient-Derived Platinum-Resistant Ovarian Carcinomas Open
Platinum resistance represents an urgent medical need in the management of ovarian cancer. The activity of the combinations of onvansertib, an inhibitor of polo-like kinase 1, with gemcitabine or carboplatin was tested using patient-derive…
View article: Sex-dependent modulation of caerulein-induced acute pancreatitis in C57BL/6J mice
Sex-dependent modulation of caerulein-induced acute pancreatitis in C57BL/6J mice Open
Acute pancreatitis (AP) is a life-threatening condition, with a higher mortality rate in men than women and in which estrogens might play a protective role. This study aimed to investigate sex-dependent differences in a mouse model of caer…
View article: Onvansertib treatment overcomes olaparib resistance in high-grade ovarian carcinomas
Onvansertib treatment overcomes olaparib resistance in high-grade ovarian carcinomas Open
Occurrence of resistance to olaparib, a poly(ADP-ribose) polymerase (PARP) inhibitor (PARPi) approved in ovarian carcinoma, has already been shown in clinical settings. Identifying combination treatments to sensitize tumor cells and/or ove…
View article: <i>Pneumocystis murina</i> lesions in lungs of experimentally infected Cd40l<sup>–/–</sup> mice
<i>Pneumocystis murina</i> lesions in lungs of experimentally infected Cd40l<sup>–/–</sup> mice Open
The Cd40l –/– mouse is a well-established model of X-linked hyper-immunoglobulin M (IgM) syndrome, an immunodeficiency disorder of human beings characterized by the lack of expression of the CD40 ligand (CD40L) on activated T-cells, predis…
View article: Live or Heat-Killed Lactobacillus rhamnosus Aerosolization Decreases Adenomatous Lung Cancer Development in a Mouse Carcinogen-Induced Tumor Model
Live or Heat-Killed Lactobacillus rhamnosus Aerosolization Decreases Adenomatous Lung Cancer Development in a Mouse Carcinogen-Induced Tumor Model Open
An immunosuppressive microenvironment in lung concurs to pre-malignant lesions progression to cancer. Here, we explore if perturbing lung microbiota, which contribute to immunosuppression, by antibiotics or probiotic aerosol interferes wit…
View article: Extracellular vesicles from seminal plasma to improve fertilizing capacity of bulls
Extracellular vesicles from seminal plasma to improve fertilizing capacity of bulls Open
Extracellular vesicles (EVs) contained in seminal plasma, vehicle RNA, proteins, and other molecules able to influence the biological function of sperm. The aim of this study was to improve the fertilizing capacity of male gametes of low-f…