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View article: Line-Field Confocal Optical Coherence Tomography of Basal Cell Carcinoma: Systematic Correlation with Histopathology
Line-Field Confocal Optical Coherence Tomography of Basal Cell Carcinoma: Systematic Correlation with Histopathology Open
Background/Objectives: Basal cell carcinoma (BCC) is the most frequent skin cancer in Caucasian populations. While dermoscopy supports diagnosis, accurate subtype classification requires histopathology. Line-field confocal optical coherenc…
View article: Line-Field Confocal Optical Coherence Tomography for the Evaluation of Pigmented Skin Lesions of the Genital Area
Line-Field Confocal Optical Coherence Tomography for the Evaluation of Pigmented Skin Lesions of the Genital Area Open
Background/Objectives: Pigmented lesions of the genital area are of commonly occurrence, with population-based incidence estimated around 10–20%. Historically, invasive biopsy or surgical removal were recommended to obtain a definite diagn…
View article: Locally advanced basal cell carcinoma treated with sonidegib: <i>in vivo</i> monitoring with line-field confocal optical coherence tomography
Locally advanced basal cell carcinoma treated with sonidegib: <i>in vivo</i> monitoring with line-field confocal optical coherence tomography Open
Background Hedgehog pathway inhibitors, including sonidegib and vismodegib, represent the treatment strategy for ‘difficult-to-treat’ basal cell carcinoma (BCC), encompassing, among others, locally advanced (laBCC) and metastatic BCC. Asse…
View article: Dermoscopy, Line-Field Confocal Optical Coherence Tomography, Reflectance Confocal Microscopy, and Ultra-High-Frequency Ultrasound: Clues for the Diagnosis of Hidrocystomas
Dermoscopy, Line-Field Confocal Optical Coherence Tomography, Reflectance Confocal Microscopy, and Ultra-High-Frequency Ultrasound: Clues for the Diagnosis of Hidrocystomas Open
Background/Objectives: Hidrocystomas, eccrine and apocrine, are rare cystic lesions that form benign tumors of the sweat glands. This study aimed to describe the clinical features of hidrocystomas and evaluate the role of non-invasive imag…
View article: <scp>LC</scp>‐<scp>OCT</scp> for early diagnosis and characterization of dermatologic adverse events to oncologic drugs and correlation to histopathology
<span>LC</span>‐<span>OCT</span> for early diagnosis and characterization of dermatologic adverse events to oncologic drugs and correlation to histopathology Open
Background Targeted and immune therapies have recently been associated with the occurrence of multiple cutaneous toxicities, often challenging to differentiate by clinical examination alone without histology. Line‐field confocal optical co…
View article: Trichoscopy and LC-OCT findings in sonidegib-induced alopecia in patients with advanced basal cell carcinoma
Trichoscopy and LC-OCT findings in sonidegib-induced alopecia in patients with advanced basal cell carcinoma Open
Sonidegib is a Hedgehog pathway inhibitor (HHIs) used as first-line systemic treatment for patients with advanced basal cell carcinoma (aBCC). Alopecia is reported as a frequent adverse event (AE), occurring in 49% of patients. Forty-five …
View article: In Vivo Reflectance Confocal Microscopy Applied to Acral Melanocytic Lesions: A Systematic Review of the Literature
In Vivo Reflectance Confocal Microscopy Applied to Acral Melanocytic Lesions: A Systematic Review of the Literature Open
Background: Acral melanocytic lesions often pose a diagnostic and therapeutic challenge for many clinicians. Reflectance confocal microscopy (RCM) is an imaging technique widely used for the assessment of skin cancers. The aim of this revi…
View article: Line-Field Confocal Optical Coherence Tomography: A New Skin Imaging Technique Reproducing a “Virtual Biopsy” with Evolving Clinical Applications in Dermatology
Line-Field Confocal Optical Coherence Tomography: A New Skin Imaging Technique Reproducing a “Virtual Biopsy” with Evolving Clinical Applications in Dermatology Open
Background: Line-field confocal optical coherence tomography is a novel technology able to reproduce a “virtual biopsy” of the skin. The aim of this review is to explore the application of line-field confocal optical coherence tomography (…
View article: Digital imaging of ink spot lentigo: Confocal microscopy and line‐field confocal optical coherence tomography assessment
Digital imaging of ink spot lentigo: Confocal microscopy and line‐field confocal optical coherence tomography assessment Open
The reticulated black solar lentigo was initially described by Bolognia et al. in 1992 as a type of solar lentigo.1 Ink spot lentigo (ISL), as commonly known, clinically presents as a solitary dark pigmented macule with ill-defined margins…
View article: Understanding the Dermoscopic Patterns of Basal Cell Carcinoma Using Line-Field Confocal Tomography
Understanding the Dermoscopic Patterns of Basal Cell Carcinoma Using Line-Field Confocal Tomography Open
Basal cell carcinoma (BCC) is the most frequent malignancy in the general population. To date, dermoscopy is considered a key tool for the diagnosis of BCC; nevertheless, line-field confocal optical coherence tomography (LC-OCT), a new non…
View article: The Role of Postoperative Radiotherapy in the Management of Dermatofibrosarcoma Protuberans: A Multidisciplinary Systematic Review
The Role of Postoperative Radiotherapy in the Management of Dermatofibrosarcoma Protuberans: A Multidisciplinary Systematic Review Open
Background: Dermatofibrosarcoma protuberans (DFSP) is a superficial soft tissue sarcoma, and surgical excision is the first-line treatment. The aim of this systematic review is to provide an update about the current indications and clinica…
View article: ChatGPT for skin cancer prevention: High patients' satisfaction to educational material
ChatGPT for skin cancer prevention: High patients' satisfaction to educational material Open
In this rapidly evolving technological era, ChatGPT represents a significant breakthrough in the field of artificial intelligence (AI), being a pivotal source of virtual content generation.1 Developed by OpenAI, ChatGPT harnesses the poten…
View article: Confocal Assessment of Pigmented-Mucosal Lesions: A Monocentric, Retrospective Evaluation of Lip and Genital Area
Confocal Assessment of Pigmented-Mucosal Lesions: A Monocentric, Retrospective Evaluation of Lip and Genital Area Open
Introduction: Pigmentation of lip and/or genitalia is mainly due to the development of benign melanotic macules, with a less occurrence of melanocytic and other non-melanocytic lesions. Mucosal melanoma has worse prognosis compared with cu…
View article: Real-Life Experience with Sonidegib for Locally Advanced Basosquamous Carcinoma: A Case Series
Real-Life Experience with Sonidegib for Locally Advanced Basosquamous Carcinoma: A Case Series Open
Introduction: Basosquamous carcinoma is an uncommon subtype of basal cell carcinoma (BCC), characterized by aggressive local growth and metastatic potential, that mainly develops on the nose, perinasal area, and ears, representing 1.2–2.7%…
View article: Supplementary Material for: Real-life experience with sonidegib for locally advanced basosquamous carcinoma: a case series
Supplementary Material for: Real-life experience with sonidegib for locally advanced basosquamous carcinoma: a case series Open
Introduction: Basosquamous carcinoma is an uncommon subtype of basal cell carcinoma, characterized by aggressive local growth and metastatic potential, that mainly develops on the nose, perinasal area and ears, representing 1.2%-2.7% of al…
View article: Preoperative evaluation of high-risk basal cell carcinoma with line-field confocal optical coherence tomography (LC-OCT) reduces Mohs micrographic surgery stage number: A case-control study
Preoperative evaluation of high-risk basal cell carcinoma with line-field confocal optical coherence tomography (LC-OCT) reduces Mohs micrographic surgery stage number: A case-control study Open
Background: Mohs micrographic surgery (MMS) is the preferred surgical approach for high-risk basal cell carcinoma (BCC). Pre-surgical tumor margins delineation with line field confocal optical coherence tomography (LC-OCT) is expected to r…
View article: Line-Field Confocal Optical Coherence Tomography Evaluation of Eyelid Skin Lesions
Line-Field Confocal Optical Coherence Tomography Evaluation of Eyelid Skin Lesions Open
Background: Periocular malignancies may be clinically different from the examples arising at other sites, with possible delayed diagnosis and greater challenges for treatment and repair. Line-field confocal optical coherence tomography (LC…
View article: Eruptive lentiginosis in resolving plaque psoriasis during treatment with risankizumab
Eruptive lentiginosis in resolving plaque psoriasis during treatment with risankizumab Open
Risankizumab is a humanized IgG1 monoclonal antibody targeting the p19 subunit of IL-23, approved for the treatment of moderate-severe psoriasis.1 Here we describe a patient who developed a lentiginous eruption on skin areas previously aff…
View article: Line-field confocal optical coherence tomography in melanocytic and non-melanocytic skin tumors
Line-field confocal optical coherence tomography in melanocytic and non-melanocytic skin tumors Open
LC-OCT proved to increase the diagnostic accuracy for melanocytic and non-melanocytic skin lesions, thanks to the combination of high resolution/penetration, 3D reconstructions, and integrated dermoscopy. Although BCC seems the most suitab…
View article: Towards AI-driven longevity research: An overview
Towards AI-driven longevity research: An overview Open
While in the past technology has mostly been utilized to store information about the structural configuration of proteins and molecules for research and medical purposes, Artificial Intelligence is nowadays able to learn from the existing …
View article: Melanocytic Lesions With Peripheral Globules: Proposal Of An Integrated Management Algorithm
Melanocytic Lesions With Peripheral Globules: Proposal Of An Integrated Management Algorithm Open
Introduction: A peripheral rim of globules represents a marker of horizontal growth phase in nevi and is a common feature in children and adolescents. The observation of melanocytic lesion with peripheral globules (MLPG) in adulthood deser…
View article: Comparison of reflectance confocal microscopy and line‐field optical coherence tomography for the identification of keratinocyte skin tumours
Comparison of reflectance confocal microscopy and line‐field optical coherence tomography for the identification of keratinocyte skin tumours Open
Background Reflectance confocal microscopy (RCM) and line‐field confocal optical coherence tomography (LC‐OCT) are non‐invasive imaging devices that can help in the clinical diagnosis of actinic keratosis (AK) and cutaneous squamous cell c…
View article: Alopecia Areata Occurring after COVID-19 Vaccination: A Single-Center, Cross-Sectional Study
Alopecia Areata Occurring after COVID-19 Vaccination: A Single-Center, Cross-Sectional Study Open
Limited data concerning the development of autoimmune skin diseases after COVID-19 vaccination are currently available. Recently, a few reports described the development, worsening or recurrence of alopecia areata after the administration …