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View article: Supplementary Figure S2 from Necroptosis-dependent Immunogenicity of Cisplatin: Implications for Enhancing the Radiation-induced Abscopal Effect
Supplementary Figure S2 from Necroptosis-dependent Immunogenicity of Cisplatin: Implications for Enhancing the Radiation-induced Abscopal Effect Open
Potency of platinum derivatives to facilitate the RT-induced abscopal effect in the C51 colon carcinoma model.
View article: Supplementary Figure S5 from Necroptosis-dependent Immunogenicity of Cisplatin: Implications for Enhancing the Radiation-induced Abscopal Effect
Supplementary Figure S5 from Necroptosis-dependent Immunogenicity of Cisplatin: Implications for Enhancing the Radiation-induced Abscopal Effect Open
Cisplatin induced ferroptosis without affecting ATP release, but not pyroptosis.
View article: Supplementary Table S5 from Necroptosis-dependent Immunogenicity of Cisplatin: Implications for Enhancing the Radiation-induced Abscopal Effect
Supplementary Table S5 from Necroptosis-dependent Immunogenicity of Cisplatin: Implications for Enhancing the Radiation-induced Abscopal Effect Open
Published papers on clinical cohorts/ongoing clinical trials using sequential or concurrent hRT/SBRT and cisplatin or carboplatin-based chemotherapy
View article: Supplementary Figure S4 from Necroptosis-dependent Immunogenicity of Cisplatin: Implications for Enhancing the Radiation-induced Abscopal Effect
Supplementary Figure S4 from Necroptosis-dependent Immunogenicity of Cisplatin: Implications for Enhancing the Radiation-induced Abscopal Effect Open
Cell death and viability assays.
View article: Supplementary Figure S9 from Necroptosis-dependent Immunogenicity of Cisplatin: Implications for Enhancing the Radiation-induced Abscopal Effect
Supplementary Figure S9 from Necroptosis-dependent Immunogenicity of Cisplatin: Implications for Enhancing the Radiation-induced Abscopal Effect Open
Combination of the typical T-effector cytokines TNFa and IFNg can induce tumor cell necroptosis.
View article: Supplementary Table S4 from Necroptosis-dependent Immunogenicity of Cisplatin: Implications for Enhancing the Radiation-induced Abscopal Effect
Supplementary Table S4 from Necroptosis-dependent Immunogenicity of Cisplatin: Implications for Enhancing the Radiation-induced Abscopal Effect Open
ICB trials analyzed in Figure 6C and D.
View article: Supplementary Figure S10 from Necroptosis-dependent Immunogenicity of Cisplatin: Implications for Enhancing the Radiation-induced Abscopal Effect
Supplementary Figure S10 from Necroptosis-dependent Immunogenicity of Cisplatin: Implications for Enhancing the Radiation-induced Abscopal Effect Open
Graphical summary.
View article: Supplementary Table S3 from Necroptosis-dependent Immunogenicity of Cisplatin: Implications for Enhancing the Radiation-induced Abscopal Effect
Supplementary Table S3 from Necroptosis-dependent Immunogenicity of Cisplatin: Implications for Enhancing the Radiation-induced Abscopal Effect Open
P values for Spearman's correlation coefficient and hazard ratio data shown in Table S2.
View article: Supplementary Figure S1 from Necroptosis-dependent Immunogenicity of Cisplatin: Implications for Enhancing the Radiation-induced Abscopal Effect
Supplementary Figure S1 from Necroptosis-dependent Immunogenicity of Cisplatin: Implications for Enhancing the Radiation-induced Abscopal Effect Open
Potency of platinum derivatives to facilitate the RT-induced abscopal effect in the B16-CD133 melanoma model.
View article: Author Correction: Expansion of circulating stem-like CD8+ T cells by adding CD122-directed IL-2 complexes to radiation and anti-PD1 therapies in mice
Author Correction: Expansion of circulating stem-like CD8+ T cells by adding CD122-directed IL-2 complexes to radiation and anti-PD1 therapies in mice Open
View article: Hypofractionated radiotherapy combined with lenalidomide improves systemic antitumor activity in mouse solid tumor models
Hypofractionated radiotherapy combined with lenalidomide improves systemic antitumor activity in mouse solid tumor models Open
Background: Hypofractionated radiotherapy (hRT) can induce a T cell-mediated abscopal effect on non-irradiated tumor lesions, especially in combination with immune checkpoint blockade (ICB). However, clinically, this effect is still…
View article: Adding liposomal doxorubicin enhances the abscopal effect induced by radiation/αPD1 therapy depending on tumor cell mitochondrial DNA and cGAS/STING
Adding liposomal doxorubicin enhances the abscopal effect induced by radiation/αPD1 therapy depending on tumor cell mitochondrial DNA and cGAS/STING Open
Background Localized radiotherapy (RT) can cause a T cell-mediated abscopal effect on non-irradiated tumor lesions, especially in combination with immune checkpoint blockade. However, this effect is still clinically rare and improvements a…
View article: Expansion of circulating stem-like CD8+ T cells by adding CD122-directed IL-2 complexes to radiation and anti-PD1 therapies in mice
Expansion of circulating stem-like CD8+ T cells by adding CD122-directed IL-2 complexes to radiation and anti-PD1 therapies in mice Open
View article: Supplementary Figure S3 from Necroptosis-dependent Immunogenicity of Cisplatin: Implications for Enhancing the Radiation-induced Abscopal Effect
Supplementary Figure S3 from Necroptosis-dependent Immunogenicity of Cisplatin: Implications for Enhancing the Radiation-induced Abscopal Effect Open
RIPK3 expression in tumor cells in vitro and ex vivo and dependence of extracellular ATP on RIPK1.
View article: Supplementary Figure S7 from Necroptosis-dependent Immunogenicity of Cisplatin: Implications for Enhancing the Radiation-induced Abscopal Effect
Supplementary Figure S7 from Necroptosis-dependent Immunogenicity of Cisplatin: Implications for Enhancing the Radiation-induced Abscopal Effect Open
Expression and functional analyses of tumor cells cultured in vitro or analyzed ex vivo.
View article: Supplementary Figure S3 from Necroptosis-dependent Immunogenicity of Cisplatin: Implications for Enhancing the Radiation-induced Abscopal Effect
Supplementary Figure S3 from Necroptosis-dependent Immunogenicity of Cisplatin: Implications for Enhancing the Radiation-induced Abscopal Effect Open
RIPK3 expression in tumor cells in vitro and ex vivo and dependence of extracellular ATP on RIPK1.
View article: Data from Necroptosis-dependent Immunogenicity of Cisplatin: Implications for Enhancing the Radiation-induced Abscopal Effect
Data from Necroptosis-dependent Immunogenicity of Cisplatin: Implications for Enhancing the Radiation-induced Abscopal Effect Open
Purpose:Cisplatin is increasingly used in chemoimmunotherapy and may enhance the T cell–dependent radiation-induced abscopal effect, but how it promotes antitumor immunity is poorly understood. We investigated whether and why cisplatin is …
View article: Supplementary Figure S5 from Necroptosis-dependent Immunogenicity of Cisplatin: Implications for Enhancing the Radiation-induced Abscopal Effect
Supplementary Figure S5 from Necroptosis-dependent Immunogenicity of Cisplatin: Implications for Enhancing the Radiation-induced Abscopal Effect Open
Cisplatin induced ferroptosis without affecting ATP release, but not pyroptosis.
View article: Supplementary Figure S11 from Necroptosis-dependent Immunogenicity of Cisplatin: Implications for Enhancing the Radiation-induced Abscopal Effect
Supplementary Figure S11 from Necroptosis-dependent Immunogenicity of Cisplatin: Implications for Enhancing the Radiation-induced Abscopal Effect Open
Carboplatin induced Ifnb1, Cxcl10, as well as cytosolic mtDNA and gDNA in C51 cells in vitro.
View article: Supplementary Figure S7 from Necroptosis-dependent Immunogenicity of Cisplatin: Implications for Enhancing the Radiation-induced Abscopal Effect
Supplementary Figure S7 from Necroptosis-dependent Immunogenicity of Cisplatin: Implications for Enhancing the Radiation-induced Abscopal Effect Open
Expression and functional analyses of tumor cells cultured in vitro or analyzed ex vivo.
View article: Supplementary Figure S11 from Necroptosis-dependent Immunogenicity of Cisplatin: Implications for Enhancing the Radiation-induced Abscopal Effect
Supplementary Figure S11 from Necroptosis-dependent Immunogenicity of Cisplatin: Implications for Enhancing the Radiation-induced Abscopal Effect Open
Carboplatin induced Ifnb1, Cxcl10, as well as cytosolic mtDNA and gDNA in C51 cells in vitro.
View article: Supplementary Table S1 from Necroptosis-dependent Immunogenicity of Cisplatin: Implications for Enhancing the Radiation-induced Abscopal Effect
Supplementary Table S1 from Necroptosis-dependent Immunogenicity of Cisplatin: Implications for Enhancing the Radiation-induced Abscopal Effect Open
IC50 of platinum derivatives for B16-CD133 and C51 tumor cells.
View article: Supplementary Table S5 from Necroptosis-dependent Immunogenicity of Cisplatin: Implications for Enhancing the Radiation-induced Abscopal Effect
Supplementary Table S5 from Necroptosis-dependent Immunogenicity of Cisplatin: Implications for Enhancing the Radiation-induced Abscopal Effect Open
Published papers on clinical cohorts/ongoing clinical trials using sequential or concurrent hRT/SBRT and cisplatin or carboplatin-based chemotherapy
View article: Supplementary Figure S1 from Necroptosis-dependent Immunogenicity of Cisplatin: Implications for Enhancing the Radiation-induced Abscopal Effect
Supplementary Figure S1 from Necroptosis-dependent Immunogenicity of Cisplatin: Implications for Enhancing the Radiation-induced Abscopal Effect Open
Potency of platinum derivatives to facilitate the RT-induced abscopal effect in the B16-CD133 melanoma model.
View article: Supplementary Table S3 from Necroptosis-dependent Immunogenicity of Cisplatin: Implications for Enhancing the Radiation-induced Abscopal Effect
Supplementary Table S3 from Necroptosis-dependent Immunogenicity of Cisplatin: Implications for Enhancing the Radiation-induced Abscopal Effect Open
P values for Spearman's correlation coefficient and hazard ratio data shown in Table S2.
View article: Supplementary Figure S5 from Necroptosis-dependent Immunogenicity of Cisplatin: Implications for Enhancing the Radiation-induced Abscopal Effect
Supplementary Figure S5 from Necroptosis-dependent Immunogenicity of Cisplatin: Implications for Enhancing the Radiation-induced Abscopal Effect Open
Cisplatin induced ferroptosis without affecting ATP release, but not pyroptosis.
View article: Supplementary Table S3 from Necroptosis-dependent Immunogenicity of Cisplatin: Implications for Enhancing the Radiation-induced Abscopal Effect
Supplementary Table S3 from Necroptosis-dependent Immunogenicity of Cisplatin: Implications for Enhancing the Radiation-induced Abscopal Effect Open
P values for Spearman's correlation coefficient and hazard ratio data shown in Table S2.
View article: Supplementary Table S4 from Necroptosis-dependent Immunogenicity of Cisplatin: Implications for Enhancing the Radiation-induced Abscopal Effect
Supplementary Table S4 from Necroptosis-dependent Immunogenicity of Cisplatin: Implications for Enhancing the Radiation-induced Abscopal Effect Open
ICB trials analyzed in Figure 6C and D.
View article: Supplementary Figure S2 from Necroptosis-dependent Immunogenicity of Cisplatin: Implications for Enhancing the Radiation-induced Abscopal Effect
Supplementary Figure S2 from Necroptosis-dependent Immunogenicity of Cisplatin: Implications for Enhancing the Radiation-induced Abscopal Effect Open
Potency of platinum derivatives to facilitate the RT-induced abscopal effect in the C51 colon carcinoma model.
View article: Supplementary Figure S8 from Necroptosis-dependent Immunogenicity of Cisplatin: Implications for Enhancing the Radiation-induced Abscopal Effect
Supplementary Figure S8 from Necroptosis-dependent Immunogenicity of Cisplatin: Implications for Enhancing the Radiation-induced Abscopal Effect Open
Long-lasting immune memory in platinum-treated mice cured from C51 tumors.