Simone Garcovich
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View article: LAight Therapy is an Effective and Gentle Treatment in Adolescents Suffering from Hidradenitis Suppurative: Results from 96 Patients Using Real-world Data
LAight Therapy is an Effective and Gentle Treatment in Adolescents Suffering from Hidradenitis Suppurative: Results from 96 Patients Using Real-world Data Open
Hidradenitis suppurativa (HS) is a chronic skin condition characterized by the formation of painful nodules, abscesses, and tunnels, typically in intertriginous areas. While HS primarily affects adults, it causes in particular severe distr…
View article: European Guideline on Chronic Pruritus. In cooperation with the European Dermatology Forum (EDF)
European Guideline on Chronic Pruritus. In cooperation with the European Dermatology Forum (EDF) Open
Pruritus is a frequent symptom in medicine. Population-based studies show that one in five persons in the general population has suffered from chronic pruritus (CP) at least once in their lifetime, with a 12-month incidence of 7%. CP, whic…
View article: Hidradenitis Suppurativa in the SARS-CoV-2 Pandemic: Investigation of Trigger Factors in a Single Center
Hidradenitis Suppurativa in the SARS-CoV-2 Pandemic: Investigation of Trigger Factors in a Single Center Open
Background: Hidradenitis suppurativa (HS) is a debilitating, chronic inflammatory disease associated with multiple triggers. As the world struggles with the global COVID-19 pandemic, it is important to review the trigger factors for chroni…
View article: Real‐world effectiveness and safety of the LAight‐therapy in patients with hidradenitis suppurativa
Real‐world effectiveness and safety of the LAight‐therapy in patients with hidradenitis suppurativa Open
Summary Background and objectives Hidradenitis suppurativa (HS)/Acne inversa (Ai) is a chronic debilitating disease with limited therapy options. The device‐based LAight therapy was approved in Europe in 2017. The aim of this study was to …
View article: EADV Task Force Pruritus White Paper on chronic pruritus and chronic prurigo: Current challenges and future solutions
EADV Task Force Pruritus White Paper on chronic pruritus and chronic prurigo: Current challenges and future solutions Open
Chronic pruritus (CP) is frequent in general medicine and the most common complaint in general dermatology. The prevalence of CP is expected to rise in the future due to the ageing population. The clinical presentation, underlying aetiolog…
View article: Chronic nodular prurigo: Association between comorbidities, itch and quality of life
Chronic nodular prurigo: Association between comorbidities, itch and quality of life Open
International audience
View article: Self-management-competency as a new target in Hidradenitis suppurativa care
Self-management-competency as a new target in Hidradenitis suppurativa care Open
Background: Hidradenitis suppurativa affects approximately 1% of the population.Objective: Highlighting the relevance of self-management-competency as a new therapeutic target.Method: 258 patients from the 'Epidemiology and Care in Acne in…
View article: Systematic review: Impact of stem cells-based therapy, and platelet-rich plasma in hair loss and telogen effluvium related to COVID-19
Systematic review: Impact of stem cells-based therapy, and platelet-rich plasma in hair loss and telogen effluvium related to COVID-19 Open
Collected data confirmed both an increased incidence of HL and TE in COVID-19 patients, preliminarily, the related effectiveness of AD-MSCs, HFSCs, and PRP without major side effects.
View article: Chronic prurigo: Insufficient disease control in spite of high healthcare usage
Chronic prurigo: Insufficient disease control in spite of high healthcare usage Open
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View article: Similar Levels of Efficacy of Two Different Maintenance Doses of Adalimumab on Clinical Severity and Quality of Life of Patients with Hidradenitis Suppurativa
Similar Levels of Efficacy of Two Different Maintenance Doses of Adalimumab on Clinical Severity and Quality of Life of Patients with Hidradenitis Suppurativa Open
Adalimumab is the only biologic agent approved for the treatment of moderate-to-severe hidradenitis suppurativa (HS) patients (i.e., with Hurley II or III), which is recommended in two different maintenance doses (i.e., 40 mg weekly or 80 …
View article: Supplementary Material for: Whole-Exome Sequencing in 10 Unrelated Patients with Syndromic Hidradenitis Suppurativa: A Preliminary Step for a Genotype-Phenotype Correlation
Supplementary Material for: Whole-Exome Sequencing in 10 Unrelated Patients with Syndromic Hidradenitis Suppurativa: A Preliminary Step for a Genotype-Phenotype Correlation Open
Background: The genetics of syndromic hidradenitis suppurativa (HS), an immune-mediated condition associated with systemic comorbidities such as inflammatory bowel diseases and arthritis, has not been completely elucidated. Objective: To d…
View article: Regenerative Biotechnologies in Plastic Surgery: A Multicentric, Retrospective, Case-Series Study on the Use of Micro-Needling with Low-Level Light/Laser Therapy as a Hair Growth Boost in Patients Affected by Androgenetic Alopecia
Regenerative Biotechnologies in Plastic Surgery: A Multicentric, Retrospective, Case-Series Study on the Use of Micro-Needling with Low-Level Light/Laser Therapy as a Hair Growth Boost in Patients Affected by Androgenetic Alopecia Open
A new biotechnology based on micro-needling (MND) with low-level light/laser therapy (LLLT) that is used for hair re-growth (HR-G) needs to be standardized. The study aims to report the clinical outcomes resulting from a multicentric, retr…
View article: The Effectiveness of Low-Level Light/Laser Therapy on Hair Loss
The Effectiveness of Low-Level Light/Laser Therapy on Hair Loss Open
Background: A systematic review on low-level light/laser therapy (LLLT) in male pattern hair loss (MPHL) and female pattern hair loss (FPHL) has been performed. Objectives: Compare the reported effectiveness of LLLT in MPHL and FPHL with a…
View article: Blistering lesions associated with Waldenström macroglobulinemia: New insights into pathogenesis
Blistering lesions associated with Waldenström macroglobulinemia: New insights into pathogenesis Open
A 69-years old woman showed recurrent vesicles on both dorsal feet and hands (Figure 1A,B). The lesions have been developed over the years. A monoclonal IgM component (3350 mg/dl) and lambda light chain with no evidence of Bence-Jones prot…
View article: Adipose-Derived Mesenchymal Stem Cells (AD-MSCs) against Ultraviolet (UV) Radiation Effects and the Skin Photoaging
Adipose-Derived Mesenchymal Stem Cells (AD-MSCs) against Ultraviolet (UV) Radiation Effects and the Skin Photoaging Open
The skin is a natural barrier against the ultraviolet (UV) radiation of sunlight. The long-term and/or repetitive exposure to the sunlight and related UV radiation may change the skin structure, decreasing collagen production, promoting pr…
View article: Pruritus as a Distinctive Feature of Type 2 Inflammation
Pruritus as a Distinctive Feature of Type 2 Inflammation Open
Pruritus is a common symptom of several skin diseases, both inflammatory and neoplastic. Pruritus might have a tremendous impact on patients’ quality of life and strongly interfere with sleep, social, and work activities. We review the rol…
View article: Systematic Review: Adipose-Derived Mesenchymal Stem Cells, Platelet-Rich Plasma and Biomaterials as New Regenerative Strategies in Chronic Skin Wounds and Soft Tissue Defects
Systematic Review: Adipose-Derived Mesenchymal Stem Cells, Platelet-Rich Plasma and Biomaterials as New Regenerative Strategies in Chronic Skin Wounds and Soft Tissue Defects Open
The number of clinical trials evaluating adipose-derived mesenchymal stem cells (AD-MSCs), platelet-rich plasma (PRP), and biomaterials efficacy in regenerative plastic surgery has exponentially increased during the last ten years. AD-MSCs…
View article: Pruritus Intensity Scales across Europe: a prospective validation study
Pruritus Intensity Scales across Europe: a prospective validation study Open
Background Chronic pruritus (CP) is a subjective symptom, and it is necessary to assess its intensity with validated patient‐reported outcome tools in order to allow determination of the treatment course. Objectives So far, the itch intens…
View article: Chronic Nodular Prurigo: A European Cross-sectional Study of Patient Perspectives on Therapeutic Goals and Satisfaction
Chronic Nodular Prurigo: A European Cross-sectional Study of Patient Perspectives on Therapeutic Goals and Satisfaction Open
Chronic nodular prurigo is characterized by recalcitrant itch. Patient perspectives on therapeutic goals, satisfaction with therapy and efficacy of therapeutic regimens for this condition are unknown. This questionnaire study examined thes…
View article: Prevalence of Neuropathic Pain and Related Characteristics in Hidradenitis Suppurativa: A Cross-Sectional Study
Prevalence of Neuropathic Pain and Related Characteristics in Hidradenitis Suppurativa: A Cross-Sectional Study Open
Background: Pain is a core symptom of hidradenitis suppurativa (HS) and is of complex, multifactorial origin. HS patients frequently report typical neuropathic pain qualities, but its prevalence has been poorly described. Methods: In this …
View article: Google search trends for itch in Europe: a retrospective longitudinal study
Google search trends for itch in Europe: a retrospective longitudinal study Open
Background Itch is a common symptom in the general population. Affected individuals often do not seek medical consultation and rely on Internet searches to obtain information regarding their itch. Objectives The aim of this study was to at…
View article: IFSI-guideline on chronic prurigo including prurigo nodularis
IFSI-guideline on chronic prurigo including prurigo nodularis Open
Chronic prurigo (CPG) is a highly burdensome pruritic disease characterized by chronic itch, a prolonged scratching behavior and the development of localized or generalized hyperkeratotic pruriginous lesions. Neuronal sensitization and the…
View article: Comorbid acne inversa and Dowling–Degos disease due to a single <i>NCSTN</i> mutation: is there enough evidence? Reply from the authors
Comorbid acne inversa and Dowling–Degos disease due to a single <i>NCSTN</i> mutation: is there enough evidence? Reply from the authors Open
We thank Hermasch et al. for their comments on our paper describing the novel NCSTN R583* mutation associated to familial acne inversa (FAI) in an Italian family, where the proband was also clinically diagnosed with Dowling-Degos disease (…