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View article: The Role of Molecular Autopsy in Concealed Cardiomyopathies
The Role of Molecular Autopsy in Concealed Cardiomyopathies Open
A conclusive and early diagnosis of cardiomyopathy is essential for implementing preventive therapeutic measures and, therefore, reducing the risk of malignant arrhythmias and even sudden cardiac death. Occasionally, this lethal event can …
View article: Toxicity of Recreational Drugs and Medications During Lactation: A Systematic Review
Toxicity of Recreational Drugs and Medications During Lactation: A Systematic Review Open
Breastfeeding is recommended because of its benefits for the woman and the newborn, but during lactation, pre-existing or lactation-related health conditions that require medication can expose the minor to the risk of acute or chronic into…
View article: Drug-Induced Epigenetic Alterations: A Set of Forensic Toxicological Fingerprints?—A Systematic Review
Drug-Induced Epigenetic Alterations: A Set of Forensic Toxicological Fingerprints?—A Systematic Review Open
Background/Objectives: Epigenetics refers to heritable modifications in gene expression that do not involve changes to the DNA sequence. Among these, DNA methylation, histone modifications, and non-coding RNAs play a key role in regulating…
View article: Editorial: Errors and biases in modern healthcare: public health, medico-legal and risk management aspects
Editorial: Errors and biases in modern healthcare: public health, medico-legal and risk management aspects Open
View article: Brugada syndrome in the forensic field: what do we know to date?
Brugada syndrome in the forensic field: what do we know to date? Open
Brugada Syndrome is a cardiac genetic entity associated with an elevated risk of life-threatening arrhythmias, making accurate and prompt diagnosis vital to prevent lethal outcomes. To date, no macroscopic alterations have been identified …
View article: Forensic pathological and genetic landmarks in sudden cardiac death in the young: An update
Forensic pathological and genetic landmarks in sudden cardiac death in the young: An update Open
An episode of sudden death in a young individual is a dramatic event for family members but also a challenge for cardiologists, pediatricians, forensic pathologists and researchers. In the young population, most of sudden deaths are of car…
View article: Ethical issues in the use of genetic predictions of aggressive behavior in the criminal justice system: a systematic review
Ethical issues in the use of genetic predictions of aggressive behavior in the criminal justice system: a systematic review Open
Background The use of genetic predictions of aggressive behavior in the criminal justice system remains a subject of ongoing debate. Since behavioral genetic evidence is often used in criminal defense arguments, it is crucial to critically…
View article: Lost and found: trends in litigation and compensation related to retained surgical foreign bodies
Lost and found: trends in litigation and compensation related to retained surgical foreign bodies Open
Introduction Retained surgical foreign bodies are supplies and devices unintentionally left at the surgical site. They are generally considered never events, albeit even full compliance with procedures can only minimize the risk of their o…
View article: Appropriate time interval to update ambiguous genetic diagnosis in inherited arrhythmogenic syndromes
Appropriate time interval to update ambiguous genetic diagnosis in inherited arrhythmogenic syndromes Open
View article: Fatal intoxications and inherited cardiac disorders in the young: where to draw the line?
Fatal intoxications and inherited cardiac disorders in the young: where to draw the line? Open
Sudden cardiac death represents a significant public health concern and is one of the leading causes of early mortality worldwide. The escalating use of illicit drugs, approximately 269 million people in 2018, represents a growing public h…
View article: iForensic, multicentric validation of digital whole slide images (WSI) in forensic histopathology setting according to the College of American Pathologists guidelines
iForensic, multicentric validation of digital whole slide images (WSI) in forensic histopathology setting according to the College of American Pathologists guidelines Open
Pathology has benefited from the rapid progress of image-digitizing technology during the last decade. However, the application of digital whole slide images (WSI) in forensic pathology still needs to be improved. WSI validation is crucial…
View article: Actionable Variants of Unknown Significance in Inherited Arrhythmogenic Syndromes: A Further Step Forward in Genetic Diagnosis
Actionable Variants of Unknown Significance in Inherited Arrhythmogenic Syndromes: A Further Step Forward in Genetic Diagnosis Open
Background/Objectives: Inherited arrhythmogenic syndromes comprise a heterogenic group of genetic entities that lead to malignant arrhythmias and sudden cardiac death. Genetic testing has become crucial to understand the disease etiology a…
View article: Exploring Cerebrospinal Fluid: Validation of a New Method for Quantification of 39 Drugs of Abuse by LC-MS/MS
Exploring Cerebrospinal Fluid: Validation of a New Method for Quantification of 39 Drugs of Abuse by LC-MS/MS Open
The use of cerebrospinal fluid (CSF) in post-mortem (PM) toxicological analysis is an under-addressed topic, likely due to the technical complexity of the collection of a proper sample. However, it is a matrix of significant interest since…
View article: Robotics and AI into healthcare from the perspective of European regulation: who is responsible for medical malpractice?
Robotics and AI into healthcare from the perspective of European regulation: who is responsible for medical malpractice? Open
The integration of robotics and artificial intelligence into medical practice is radically revolutionising patient care. This fusion of advanced technologies with healthcare offers a number of significant benefits, including more precise d…
View article: Medico-legal management of healthcare-associated infections: a cost-effectiveness analysis in an Italian tertiary hospital
Medico-legal management of healthcare-associated infections: a cost-effectiveness analysis in an Italian tertiary hospital Open
Introduction Healthcare-associated infections are the main reported adverse event in healthcare, with significant economic costs that include those caused by medical malpractice claims. In Italy, there is a fault-based compensation system,…
View article: Dental DNA Mutations Occurring after Death: A Novel Method for Post-Mortem Interval (PMI) Estimation
Dental DNA Mutations Occurring after Death: A Novel Method for Post-Mortem Interval (PMI) Estimation Open
Post-mortem interval (PMI) estimation remains one of the major challenges in forensic practice, especially for late PMIs beyond 7–10 days after the death of the subject. In 2022, an innovative method to investigate the occurrence of mutati…
View article: Prevalence of all epilepsies in urban informal settlements in Nairobi, Kenya: a two-stage population-based study
Prevalence of all epilepsies in urban informal settlements in Nairobi, Kenya: a two-stage population-based study Open
View article: Investigating cardiac genetic background in sudden infant death syndrome (SIDS)
Investigating cardiac genetic background in sudden infant death syndrome (SIDS) Open
View article: Negative Outcomes of Blepharoplasty and Thyroid Disorders: Is Compensation Always Due? A Case Report with a Literature Review
Negative Outcomes of Blepharoplasty and Thyroid Disorders: Is Compensation Always Due? A Case Report with a Literature Review Open
Background: Plastic surgery is one of the medical specialties with the highest risk of recurrent medical malpractice claims. The frequency of civil lawsuits represents an issue for the micro- and macro-economy of practitioners of these hea…
View article: Forensic significance and inferential value of PMCT features in charred bodies: A bicentric study
Forensic significance and inferential value of PMCT features in charred bodies: A bicentric study Open
View article: Predictive Power of Dependence and Clinical-Social Fragility Index and Risk of Fall in Hospitalized Adult Patients: A Case-Control Study
Predictive Power of Dependence and Clinical-Social Fragility Index and Risk of Fall in Hospitalized Adult Patients: A Case-Control Study Open
Objectives Accidental falls are among the leading hospitals’ adverse events, with incidence ranging from 2 to 20 events per 1.000 days/patients. The objective of this study is to assess the relationship between in-hospital falls and the sc…
View article: Effectiveness of participatory video in lowering stigma against people with mental, neurological and substance use disorders in Kenya
Effectiveness of participatory video in lowering stigma against people with mental, neurological and substance use disorders in Kenya Open
Background Globally, stigma associated with mental, neurological and substance use (MNS) disorders is rampant and a barrier to good health and overall well-being of people with these conditions. Person-centred digital approaches such as pa…
View article: Editorial: Genetics of sudden unexplained death in children and young adults: state of the art, testing and implications for translational research, public health and forensic pathology
Editorial: Genetics of sudden unexplained death in children and young adults: state of the art, testing and implications for translational research, public health and forensic pathology Open
Editorial on the Research Topic
\nGenetics of sudden unexplained death in children and young adults: state
\nof the art, testing and implications for translational research, public health
\nand forensic pathology
View article: Determination of Lysergic Acid Diethylamide and 2-Oxo-3-Hydroxy-LSD in Blood: Validation and Comparison of Two Liquid Chromatography–Tandem Mass Spectrometry Methods
Determination of Lysergic Acid Diethylamide and 2-Oxo-3-Hydroxy-LSD in Blood: Validation and Comparison of Two Liquid Chromatography–Tandem Mass Spectrometry Methods Open
Lysergic acid diethylamide (LSD) is a powerful hallucinogen. Its detection is limited by its low dosage; moreover, LSD is rapidly metabolized into 2-oxo-3-hydroxy-LSD (O-H-LSD). In this study we validated two methods for determination of L…
View article: Samples used in molecular autopsy: an update
Samples used in molecular autopsy: an update Open
Molecular autopsy makes it possible to identify the genetic alteration responsible for an inherited arrhythmogenic disease, main suspected cause of sudden death in cases that remain unexplained after a complete medico-legal autopsy. By usi…
View article: Biomarkers of traumatic brain injury in vitreous humor: A pilot study
Biomarkers of traumatic brain injury in vitreous humor: A pilot study Open
Given the peculiarity of the matrix and the poor standardization of the sampling, such promising results need to be furtherly investigated in serum before being implemented in the forensic practice.
View article: Postmortem diagnosis of Takotsubo syndrome on autoptic findings: is it reliable? A systematic review
Postmortem diagnosis of Takotsubo syndrome on autoptic findings: is it reliable? A systematic review Open
View article: Comparative Impact Analysis of Low-Deductible Insurance Versus In-house Hospital Assumption of Risk and Management on Medical Malpractice Claims
Comparative Impact Analysis of Low-Deductible Insurance Versus In-house Hospital Assumption of Risk and Management on Medical Malpractice Claims Open
Objectives Claims management is critical to ensure the safe and high-quality medical care for which liability insurers and/or hospitals are responsible. The aim of this research is to determine whether increasing hospital malpractice risk …
View article: Development and validation of a diagnostic aid for convulsive epilepsy in sub-Saharan Africa: a retrospective case-control study
Development and validation of a diagnostic aid for convulsive epilepsy in sub-Saharan Africa: a retrospective case-control study Open
The Wellcome Trust, the UK National Institute of Health Research, and the Oxford NIHR Biomedical Research Centre.
View article: A Semi-Automatic Method on a Small Italian Sample for Estimating Sex Based on the Shape of the Crown of the Maxillary Posterior Teeth
A Semi-Automatic Method on a Small Italian Sample for Estimating Sex Based on the Shape of the Crown of the Maxillary Posterior Teeth Open
Teeth are known to be reliable substrates for human identification and are endowed with significant sexual dimorphism not only in the size but also in the shape of the crowns. In the preliminary phase of our study (already published in 202…