Simone Hieber
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View article: Terabyte-scale supervised 3D training and benchmarking dataset of the mouse kidney
Terabyte-scale supervised 3D training and benchmarking dataset of the mouse kidney Open
The performance of machine learning algorithms, when used for segmenting 3D biomedical images, does not reach the level expected based on results achieved with 2D photos. This may be explained by the comparative lack of high-volume, high-q…
View article: Combining High-Resolution Hard X-ray Tomography and Histology for Stem Cell-Mediated Distraction Osteogenesis
Combining High-Resolution Hard X-ray Tomography and Histology for Stem Cell-Mediated Distraction Osteogenesis Open
Distraction osteogenesis is a clinically established technique for lengthening, molding and shaping bone by new bone formation. The experimental evaluation of this expensive and time-consuming treatment is of high impact for better underst…
View article: Terabyte-scale supervised 3D training and benchmarking dataset of the mouse kidney
Terabyte-scale supervised 3D training and benchmarking dataset of the mouse kidney Open
The performance of machine learning algorithms, when used for segmenting 3D biomedical images, does not reach the level expected based on results achieved with 2D photos. This may be explained by the comparative lack of high-volume, high-q…
View article: Ex vivo evaluation of an atherosclerotic human coronary artery via histology and high-resolution hard X-ray tomography
Ex vivo evaluation of an atherosclerotic human coronary artery via histology and high-resolution hard X-ray tomography Open
Atherosclerotic arteries exhibit characteristic constrictions and substantial deviations from cylindrical shape. Therefore, determining the artery’s cross-section along the centerline is challenging, although high-resolution isotropic thre…
View article: Hard X-ray Nano-Holotomography of Formalin-Fixated and Paraffin-Embedded Human Brain Tissue
Hard X-ray Nano-Holotomography of Formalin-Fixated and Paraffin-Embedded Human Brain Tissue Open
An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the 'Save PDF' action button.
View article: Visualization and Segmentation of Cells in Unstained Paraffin-Embedded Cerebral Tissue
Visualization and Segmentation of Cells in Unstained Paraffin-Embedded Cerebral Tissue Open
An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
View article: P1‐101: FEASIBILITY STUDY OF SYNCHROTRON‐BASED MICROTOMOGRAPHY TO IDENTIFY α‐SYNUCLEIN OLIGOMERS IN POSTMORTEM TISSUE
P1‐101: FEASIBILITY STUDY OF SYNCHROTRON‐BASED MICROTOMOGRAPHY TO IDENTIFY α‐SYNUCLEIN OLIGOMERS IN POSTMORTEM TISSUE Open
Lewy body disease (LBD) is the second most common cause of neurodegenerative dementia after Alzheimer's disease and presents a challenge to healthcare services in an ageing society because current therapeutic approaches do not halt the dis…
View article: Volumetric Nanoscale Imaging: Hard X‐Ray Nanoholotomography: Large‐Scale, Label‐Free, 3D Neuroimaging beyond Optical Limit (Adv. Sci. 6/2018)
Volumetric Nanoscale Imaging: Hard X‐Ray Nanoholotomography: Large‐Scale, Label‐Free, 3D Neuroimaging beyond Optical Limit (Adv. Sci. 6/2018) Open
In article number https://doi.org/10.1002/advs.201700694, Bert Müller and co‐workers launch nano‐holotomography for the isotropic 3D imaging of paraffin‐embedded human brain tissues. Nano‐holotomography bridges the spatial resolution gap b…
View article: Hard X‐Ray Nanoholotomography: Large‐Scale, Label‐Free, 3D Neuroimaging beyond Optical Limit
Hard X‐Ray Nanoholotomography: Large‐Scale, Label‐Free, 3D Neuroimaging beyond Optical Limit Open
There have been great efforts on the nanoscale 3D probing of brain tissues to image subcellular morphologies. However, limitations in terms of tissue coverage, anisotropic resolution, stain dependence, and complex sample preparation all hi…
View article: Three-dimensional imaging and analysis of entire peripheral nerves after repair and reconstruction
Three-dimensional imaging and analysis of entire peripheral nerves after repair and reconstruction Open
We have presented a potential way for 3D imaging and analysis of entire regenerated nerves non-destructively, paving the way for high-throughput analysis of therapeutic conditions of treating adult nerve injuries.
View article: Three-dimensional and non-destructive characterization of nerves inside conduits using laboratory-based micro computed tomography
Three-dimensional and non-destructive characterization of nerves inside conduits using laboratory-based micro computed tomography Open
We demonstrate the potential of the micro computed tomography for non-destructive monitoring of peripheral nerves inside the conduits.
View article: Hard X-ray submicrometer tomography of human brain tissue at Diamond Light Source
Hard X-ray submicrometer tomography of human brain tissue at Diamond Light Source Open
There is a lack of the necessary methodology for three-dimensional (3D) investigation of soft tissues with cellular resolution without staining or tissue transformation. Synchrotron radiation based hard X-ray in-line phase contrast tomogra…
View article: X-ray microscopy of soft and hard human tissues
X-ray microscopy of soft and hard human tissues Open
The simultaneous post mortem visualization of soft and hard tissues using absorption-based CT remains a challenge. If the photon energy is optimized for the visualization of hard tissue, the surrounding soft tissue components are almost X-…