Simone Kruithof
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View article: Formation and clearance of TNF–TNF inhibitor complexes during TNF inhibitor treatment
Formation and clearance of TNF–TNF inhibitor complexes during TNF inhibitor treatment Open
Background and Purpose Millions of patients with inflammatory diseases are treated with tumour necrosis factor (TNF) inhibitors (TNFi). Individual treatment response varies, in part related to variable drug clearance. The role of TNF–TNFi …
View article: At Critically Low Antigen Densities, IgM Hexamers Outcompete Both IgM Pentamers and IgG1 for Human Complement Deposition and Complement-Dependent Cytotoxicity
At Critically Low Antigen Densities, IgM Hexamers Outcompete Both IgM Pentamers and IgG1 for Human Complement Deposition and Complement-Dependent Cytotoxicity Open
IgM is secreted as a pentameric polymer containing a peptide called the joining chain (J chain). However, integration of the J chain is not required for IgM assembly and in its absence IgM predominantly forms hexamers. The conformations of…
View article: Dynamics of antibodies to SARS‐CoV‐2 in convalescent plasma donors
Dynamics of antibodies to SARS‐CoV‐2 in convalescent plasma donors Open
Objectives Characterisation of the human antibody response to SARS‐CoV‐2 infection is vital for serosurveillance purposes and for treatment options such as transfusion with convalescent plasma or immunoglobulin products derived from conval…
View article: Development of a SARS-CoV-2 Total Antibody Assay and the Dynamics of Antibody Response over Time in Hospitalized and Nonhospitalized Patients with COVID-19
Development of a SARS-CoV-2 Total Antibody Assay and the Dynamics of Antibody Response over Time in Hospitalized and Nonhospitalized Patients with COVID-19 Open
Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 infections often cause only mild disease that may evoke relatively low Ab titers compared with patients admitted to hospitals. Generally, total Ab bridging assays combine good sens…
View article: Development of a SARS-CoV-2 total antibody assay and the dynamics of antibody response over time in hospitalized and non-hospitalized patients with COVID-19
Development of a SARS-CoV-2 total antibody assay and the dynamics of antibody response over time in hospitalized and non-hospitalized patients with COVID-19 Open
SARS-CoV-2 infections often cause only mild disease that may evoke relatively low antibody titers compared to patients admitted to hospitals. Generally, total antibody bridging assays combine good sensitivity with high selectivity. Therefo…
View article: Divergent chemokine receptor expression and the consequence for human IgG4 B cell responses
Divergent chemokine receptor expression and the consequence for human IgG4 B cell responses Open
IgG4 antibodies are unique to humans. IgG4 is associated with tolerance during immunotherapy in allergy, but also with pathology, as in pemphigus vulgaris and IgG4‐related disease. Its induction is largely restricted to nonmicrobial antige…
View article: Reference Intervals of Factor H and Factor H-Related Proteins in Healthy Children
Reference Intervals of Factor H and Factor H-Related Proteins in Healthy Children Open
Complement is activated as part of the innate immune defense against invading pathogens. Also, it helps to remove apoptotic debris and immune complexes from the circulation. Impaired complement function due to aberrant plasma levels of com…
View article: Dimeric IgG complexes from IVIg are incapable of inducing in vitro neutrophil degranulation or complement activation
Dimeric IgG complexes from IVIg are incapable of inducing in vitro neutrophil degranulation or complement activation Open
The data suggest dimeric IgG found in IVIg may bind to Fc-receptors without causing activation.
View article: Adaptive antibody diversification through <i>N</i> -linked glycosylation of the immunoglobulin variable region
Adaptive antibody diversification through <i>N</i> -linked glycosylation of the immunoglobulin variable region Open
Significance Structural variation of antibodies is generally defined in terms of amino acid composition, neglecting posttranslational modifications such as N -linked glycosylation. Little is known about the role of the glycans that are pre…
View article: Therapeutic TNF Inhibitors can Differentially Stabilize Trimeric TNF by Inhibiting Monomer Exchange
Therapeutic TNF Inhibitors can Differentially Stabilize Trimeric TNF by Inhibiting Monomer Exchange Open
Tumor necrosis factor (TNF) is a homotrimeric cytokine that is a key mediator of inflammation. It is unstable at physiological concentrations and slowly converts into an inactive form. Here, we investigated the mechanism of this process by…