Simone Lanfredini
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View article: Tissue-resident natural killer cells support survival in pancreatic cancer through promotion of cDC1-CD8 T activity
Tissue-resident natural killer cells support survival in pancreatic cancer through promotion of cDC1-CD8 T activity Open
The immunosuppressive microenvironment in pancreatic ductal adenocarcinoma (PDAC) prevents tumor control and strategies to restore anti-cancer immunity (i.e. by increasing CD8 T-cell activity) have had limited success. Here, we demonstrate…
View article: Tissue-resident NK cells support survival in pancreatic cancer through promotion of cDC1-CD8T activity
Tissue-resident NK cells support survival in pancreatic cancer through promotion of cDC1-CD8T activity Open
The immunosuppressive microenvironment in pancreatic ductal adenocarcinoma (PDAC) prevents tumor control and strategies to restore anti-cancer immunity (i.e. by increasing CD8 T cell activity) have had limited success. Here we demonstrate …
View article: Reviewer #1 (Public Review): Tissue-resident NK cells support survival in pancreatic cancer through promotion of cDC1-CD8T activity
Reviewer #1 (Public Review): Tissue-resident NK cells support survival in pancreatic cancer through promotion of cDC1-CD8T activity Open
The immunosuppressive microenvironment in pancreatic ductal adenocarcinoma (PDAC) prevents tumor control and strategies to restore anti-cancer immunity (i.e. by increasing CD8 T cell activity) have had limited success. Here we demonstrate …
View article: Reviewer #2 (Public Review): Tissue-resident NK cells support survival in pancreatic cancer through promotion of cDC1-CD8T activity
Reviewer #2 (Public Review): Tissue-resident NK cells support survival in pancreatic cancer through promotion of cDC1-CD8T activity Open
The immunosuppressive microenvironment in pancreatic ductal adenocarcinoma (PDAC) prevents tumor control and strategies to restore anti-cancer immunity (i.e. by increasing CD8 T cell activity) have had limited success. Here we demonstrate …
View article: Pigment Epithelium Derived Factor Drives Melanocyte Proliferation and Migration in Neurofibromatosis Café Au Lait Macules
Pigment Epithelium Derived Factor Drives Melanocyte Proliferation and Migration in Neurofibromatosis Café Au Lait Macules Open
Background RASopathies, which include neurofibromatosis type 1 (NF1), are defined by Ras/mitogen-activated protein kinase (Ras/MAPK) pathway activation. They represent a group of clinically related disorders often characterised by multiple…
View article: Reviewer #3 (Public Review): Tissue-resident NK cells support survival in pancreatic cancer through promotion of cDC1-CD8T activity
Reviewer #3 (Public Review): Tissue-resident NK cells support survival in pancreatic cancer through promotion of cDC1-CD8T activity Open
The immunosuppressive microenvironment in pancreatic ductal adenocarcinoma (PDAC) prevents tumor control and strategies to restore anti-cancer immunity (i.e. by increasing CD8 T cell activity) have had limited success. Here we demonstrate …
View article: Author response: Tissue-resident NK cells support survival in pancreatic cancer through promotion of cDC1-CD8T activity
Author response: Tissue-resident NK cells support survival in pancreatic cancer through promotion of cDC1-CD8T activity Open
The immunosuppressive microenvironment in pancreatic ductal adenocarcinoma (PDAC) prevents tumor control and strategies to restore anti-cancer immunity (i.e. by increasing CD8 T cell activity) have had limited success. Here we demonstrate …
View article: Tissue-resident NK cells support survival in pancreatic cancer through promotion of cDC1-CD8T activity
Tissue-resident NK cells support survival in pancreatic cancer through promotion of cDC1-CD8T activity Open
The immunosuppressive microenvironment in PDAC prevents tumor control but strategies to restore anti-cancer immunology, by increasing CD8 T cell activity, have not been successful. Here we demonstrate how inducing localized physical damage…
View article: Tissue-resident natural killer cells support survival in pancreatic cancer through promotion of cDC1-CD8 T activity
Tissue-resident natural killer cells support survival in pancreatic cancer through promotion of cDC1-CD8 T activity Open
The immunosuppressive microenvironment in pancreatic ductal adenocarcinoma (PDAC) prevents tumor control and strategies to restore anti-cancer immunity (i.e. by increasing CD8 T-cell activity) have had limited success. Here, we demonstrate…
View article: Tissue-resident NK cells support survival in pancreatic cancer through promotion of cDC1-CD8T activity
Tissue-resident NK cells support survival in pancreatic cancer through promotion of cDC1-CD8T activity Open
The immunosuppressive microenvironment in pancreatic ductal adenocarcinoma (PDAC) prevents tumor control and strategies to restore anti-cancer immunity (i.e. by increasing CD8 T cell activity) have had limited success. Here we demonstrate …
View article: CD200 ectodomain shedding into the tumor microenvironment leads to NK cell dysfunction and apoptosis
CD200 ectodomain shedding into the tumor microenvironment leads to NK cell dysfunction and apoptosis Open
The basis of immune evasion, a hallmark of cancer, can differ even when cancers arise from one cell type such as in the human skin keratinocyte carcinomas: basal and squamous cell carcinoma. Here we showed that the basal cell carcinoma tum…
View article: Reduced respiratory motion artefact in constant TR multi-slice MRI of the mouse
Reduced respiratory motion artefact in constant TR multi-slice MRI of the mouse Open
The proposed prospective gating acquisition scheme enables efficient multi-slice scanning in small animals at the optimum TR with reduced sensitivity to respiratory motion. The method is compatible with a wide range of complementary method…
View article: HPV-Induced Field Cancerisation: Transformation of Adult Tissue Stem Cell Into Cancer Stem Cell
HPV-Induced Field Cancerisation: Transformation of Adult Tissue Stem Cell Into Cancer Stem Cell Open
Field cancerisation was originally described as a basis for multiple head and neck squamous cell carcinoma (HNSCC) and is a pre-malignant phenomenon that is frequently attributable to oncogenic human papillomavirus (HPV) infection. Our wor…
View article: β-HPV Infection Correlates with Early Stages of Carcinogenesis in Skin Tumors and Patient-Derived Xenografts from a Kidney Transplant Recipient Cohort
β-HPV Infection Correlates with Early Stages of Carcinogenesis in Skin Tumors and Patient-Derived Xenografts from a Kidney Transplant Recipient Cohort Open
Many malignancies that occur in high excess in kidney transplant recipients (KTRs) are due to viruses that thrive in the setting of immunosuppression. Keratinocyte carcinoma (KC), the most frequently occurring cancer type in KTR, has been …