Simone M. Haag
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View article: Systematic perturbation screens decode regulators of inflammatory macrophage states and identify a role for<i>TNF</i>mRNA m6A modification
Systematic perturbation screens decode regulators of inflammatory macrophage states and identify a role for<i>TNF</i>mRNA m6A modification Open
Macrophages adopt dynamic cell states with distinct effector functions to maintain tissue homeostasis and respond to environmental challenges. During chronic inflammation, macrophage polarization is subverted towards sustained inflammatory…
View article: Antigen-derived peptides engage the ER stress sensor IRE1α to curb dendritic cell cross-presentation
Antigen-derived peptides engage the ER stress sensor IRE1α to curb dendritic cell cross-presentation Open
Dendritic cells (DCs) promote adaptive immunity by cross-presenting antigen-based epitopes to CD8+ T cells. DCs process internalized protein antigens into peptides that enter the endoplasmic reticulum (ER), bind to major histocompatibility…
View article: Antigen-derived peptides directly engage the unfolded-protein sensor IRE1α to curb cross-presentation by dendritic cells
Antigen-derived peptides directly engage the unfolded-protein sensor IRE1α to curb cross-presentation by dendritic cells Open
Dendritic cells (DCs) promote adaptive immunity by cross-presenting antigen-based epitopes to CD8 + T cells. DCs process internalized protein antigens into peptides that enter the endoplasmic reticulum (ER) and upload onto major histocompa…
View article: Identification and characterisation of small-molecule inhibitors targeting STING
Identification and characterisation of small-molecule inhibitors targeting STING Open
The recognition of pathogen-derived nucleic acids is a critical mechanism by which the innate immune system detects viral infection. Upon activation, nucleic acid sensors initiate the expression of type I interferons and other inflammatory…
View article: Targeting STING with covalent small-molecule inhibitors
Targeting STING with covalent small-molecule inhibitors Open
View article: Signalling strength determines proapoptotic functions of STING
Signalling strength determines proapoptotic functions of STING Open