Stefania Mariani
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View article: GH Replacement Therapy Is Associated with Ameliorations in Body Composition and Fatty Liver Index in Patients with Adult-Onset Isolated GH Deficiency
GH Replacement Therapy Is Associated with Ameliorations in Body Composition and Fatty Liver Index in Patients with Adult-Onset Isolated GH Deficiency Open
Background/Objectives: Patients with isolated adult-onset growth hormone (GH) deficiency may present with hepatic steatosis and metabolic dysfunction. The effect of replacement therapy on metabolic phenotype has not been exhaustively studi…
View article: Development and implementation of an LC-MS-based multi-attribute method for adeno-associated virus
Development and implementation of an LC-MS-based multi-attribute method for adeno-associated virus Open
The multi-attribute method (MAM), a mass spectrometry technique for quantifying amino acid modifications at the peptide level, is becoming a prominent analytical tool in the development of biotherapeutics. The method has promise for adeno-…
View article: The Chronobiology of Hormone Administration: “Doctor, What Time Should I Take My Medication?”
The Chronobiology of Hormone Administration: “Doctor, What Time Should I Take My Medication?” Open
Pharmacotherapy involving hormones and hormone-derived molecules has various potential treatment targets. This includes addressing (partial) hormonal deficiencies, pursuing osteoanabolic effects, providing contraceptive options, or support…
View article: Correction: Eating behavior patterns, metabolic parameters and circulating oxytocin levels in patients with obesity: an exploratory study
Correction: Eating behavior patterns, metabolic parameters and circulating oxytocin levels in patients with obesity: an exploratory study Open
View article: Unexpected Conversion of Tyrosine into a Coumaric Acid Residue at the N‐Terminal Side of an Orexin Peptide Fragment Induced by UV Irradiation
Unexpected Conversion of Tyrosine into a Coumaric Acid Residue at the N‐Terminal Side of an Orexin Peptide Fragment Induced by UV Irradiation Open
The presence of reactive species exceeding the physiological self‐defense mechanisms in cells and tissues, known as oxidative stress, usually leads to damage of DNA and proteins. In this work, we analyzed the impact of UV irradiation and r…
View article: The Impact of a Very-Low-Calorie Ketogenic Diet on Monocyte Subsets of Patients with Obesity: A Pilot Study
The Impact of a Very-Low-Calorie Ketogenic Diet on Monocyte Subsets of Patients with Obesity: A Pilot Study Open
Background/Objectives: Obesity is closely linked to chronic low-grade inflammation and the development of cardio-metabolic comorbidities. Monocyte subsets, which are crucial in immune responses, have been reported to be altered in individu…
View article: Impact of a very low‐calorie ketogenic diet on metabolic and microbiota outcomes in post‐bariatric patients and bariatric‐Naïve individuals: A comparative pilot study
Impact of a very low‐calorie ketogenic diet on metabolic and microbiota outcomes in post‐bariatric patients and bariatric‐Naïve individuals: A comparative pilot study Open
Aims To date, bariatric surgery (BS) is the most effective long‐term treatment for obesity, but weight regain (WR) is common. The very low‐calorie ketogenic diet (VLCKD) is effective for weight loss and may influence gut microbiota (GM) co…
View article: Implementing a robust platform analytical procedure for measuring adeno-associated virus vector genome titer
Implementing a robust platform analytical procedure for measuring adeno-associated virus vector genome titer Open
The vector genome (vg) titer measurement, which is used to control patient dosing and ensure control over drug product manufacturing, is essential for the development of recombinant adeno-associated virus (AAV) gene therapy products. While…
View article: POMONAG: Pareto-Optimal Many-Objective Neural Architecture Generator
POMONAG: Pareto-Optimal Many-Objective Neural Architecture Generator Open
Neural Architecture Search (NAS) automates neural network design, reducing dependence on human expertise. While NAS methods are computationally intensive and dataset-specific, auxiliary predictors reduce the models needing training, decrea…
View article: Attitudes, weight stigma and misperceptions of weight loss strategies among patients living with obesity in the Lazio Region, Italy
Attitudes, weight stigma and misperceptions of weight loss strategies among patients living with obesity in the Lazio Region, Italy Open
Introduction Patient engagement is essential to achieve long-term goals in obesity management. It is crucial to identify patients’ perspectives, misperceptions and unmet educational needs on obesity etiology and treatments, to establish a …
View article: SIRT1 Serum Concentrations in Lipodystrophic Syndromes
SIRT1 Serum Concentrations in Lipodystrophic Syndromes Open
Lipodystrophies (LDs) are rare, complex disorders of the adipose tissue characterized by selective fat loss, altered adipokine profile and metabolic impairment. Sirtuins (SIRTs) are class III NAD+-dependent histone deacetylases linked to f…
View article: SIRT1 Serum Concentrations in Lipodystrophic Syndromes
SIRT1 Serum Concentrations in Lipodystrophic Syndromes Open
Lipodystrophies (LDs) are rare, complex disorders of the adipose tissue characterized by selective fat loss, altered adipokines profile and metabolic impairment. Sirtuins (SIRTs) are class III NAD+-dependent histone-deacetylases linked to …
View article: Knowledge, experiences, and perceptions relating to obesity management among primary care physicians in the Lazio Region, Italy
Knowledge, experiences, and perceptions relating to obesity management among primary care physicians in the Lazio Region, Italy Open
Background Primary care providers (PCPs) play an essential role in obesity care as they represent the first contact for patients seeking weight loss interventions. Objective This study explored the knowledge, experiences, and perceptions o…
View article: Weight Loss and Sleep, Current Evidence in Animal Models and Humans
Weight Loss and Sleep, Current Evidence in Animal Models and Humans Open
Sleep is a vital process essential for survival. The trend of reduction in the time dedicated to sleep has increased in industrialized countries, together with the dramatic increase in the prevalence of obesity and diabetes. Short sleep ma…
View article: Predictors of weight loss in patients with obesity treated with a Very Low-Calorie Ketogenic Diet
Predictors of weight loss in patients with obesity treated with a Very Low-Calorie Ketogenic Diet Open
Introduction The Very Low-Calorie Ketogenic Diet (VLCKD) has emerged as a safe and effective intervention for the management of metabolic disease. Studies examining weight loss predictors are scarce and none has investigated such factors u…
View article: Ketogenic Diet Increases Serum and White Adipose Tissue SIRT1 Expression in Mice
Ketogenic Diet Increases Serum and White Adipose Tissue SIRT1 Expression in Mice Open
Overnutrition and its sequelae have become a global concern due to the increasing incidence of obesity and insulin resistance. A ketogenic diet (KD) is widely used as a dietary treatment for metabolic disorders. Sirtuin1 (SIRT1), a metabol…
View article: Growth Hormone Secretory Capacity Is Associated with Cardiac Morphology and Function in Overweight and Obese Patients: A Controlled, Cross-Sectional Study
Growth Hormone Secretory Capacity Is Associated with Cardiac Morphology and Function in Overweight and Obese Patients: A Controlled, Cross-Sectional Study Open
Obesity is associated with increased cardiovascular morbidity. Adult patients with growth hormone deficiency (GHD) show morpho-functional cardiological alterations. A total of 353 overweight/obese patients are enrolled in the period betwee…
View article: Ketone Bodies and SIRT1, Synergic Epigenetic Regulators for Metabolic Health: A Narrative Review
Ketone Bodies and SIRT1, Synergic Epigenetic Regulators for Metabolic Health: A Narrative Review Open
Ketone bodies (KBs) and Sirtuin-1 (SIRT1) have received increasing attention over the past two decades given their pivotal function in a variety of biological contexts, including transcriptional regulation, cell cycle progression, inflamma…
View article: SARS-CoV-2 Breakthrough Infections: Incidence and Risk Factors in a Large European Multicentric Cohort of Health Workers
SARS-CoV-2 Breakthrough Infections: Incidence and Risk Factors in a Large European Multicentric Cohort of Health Workers Open
Background: The research aimed to investigate the incidence of SARS-CoV-2 breakthrough infections and their determinants in a large European cohort of more than 60,000 health workers. Methods: A multicentric retrospective cohort study, inv…
View article: Occupational Health and Safety in the Healthcare Sector
Occupational Health and Safety in the Healthcare Sector Open
Healthcare workers are exposed to several different occupational risk factors, and they pay
\nan important tribute in terms of occupational diseases and work-related injuries. Currently, the
\nCOVID-19 pandemic has focused the attention on…
View article: The Influence of Ketone Bodies on Circadian Processes Regarding Appetite, Sleep and Hormone Release: A Systematic Review of the Literature
The Influence of Ketone Bodies on Circadian Processes Regarding Appetite, Sleep and Hormone Release: A Systematic Review of the Literature Open
Chrononutrition is an emerging branch of chronobiology focusing on the profound interactions between biological rhythms and metabolism. This framework suggests that, just like all biological processes, even nutrition follows a circadian pa…
View article: Circulating SIRT1 and Sclerostin Correlates with Bone Status in Young Women with Different Degrees of Adiposity
Circulating SIRT1 and Sclerostin Correlates with Bone Status in Young Women with Different Degrees of Adiposity Open
Sirtuin1 (SIRT1) and sclerostin play important roles in adipose tissue and bone metabolism. We evaluated the circulating SIRT1 and sclerostin relationship with mass and quality of bone while considering the degree of adiposity. Sixty-six p…
View article: Application of a Machine Learning Technology in the Definition of Metabolically Healthy and Unhealthy Status: A Retrospective Study of 2567 Subjects Suffering from Obesity with or without Metabolic Syndrome
Application of a Machine Learning Technology in the Definition of Metabolically Healthy and Unhealthy Status: A Retrospective Study of 2567 Subjects Suffering from Obesity with or without Metabolic Syndrome Open
The key factors playing a role in the pathogenesis of metabolic alterations observed in many patients with obesity have not been fully characterized. Their identification is crucial, and it would represent a fundamental step towards better…
View article: Rapid Weight Loss, Central Obesity Improvement and Blood Glucose Reduction Are Associated with a Stronger Adaptive Immune Response Following COVID-19 mRNA Vaccine
Rapid Weight Loss, Central Obesity Improvement and Blood Glucose Reduction Are Associated with a Stronger Adaptive Immune Response Following COVID-19 mRNA Vaccine Open
Obesity is associated with a poor COVID-19 prognosis, and it seems associated with reduced humoral response to vaccination. Public health campaigns have advocated for weight loss in subjects with obesity, hoping to eliminate this risk. How…
View article: Ketogenic Diet for Obese COVID-19 Patients: Is Respiratory Disease a Contraindication? A Narrative Review of the Literature on Ketogenic Diet and Respiratory Function
Ketogenic Diet for Obese COVID-19 Patients: Is Respiratory Disease a Contraindication? A Narrative Review of the Literature on Ketogenic Diet and Respiratory Function Open
Morbid obese people are more likely to contract SARS-CoV-2 infection and its most severe complications, as need for mechanical ventilation. Ketogenic Diet (KD) is able to induce a fast weight loss preserving lean mass and is particularly i…
View article: Bone density and genomic analysis unfold cold adaptation mechanisms of ancient inhabitants of Tierra del Fuego
Bone density and genomic analysis unfold cold adaptation mechanisms of ancient inhabitants of Tierra del Fuego Open
The Fuegians, ancient inhabitants of Tierra del Fuego, are an exemplary case of a cold-adapted population, since they were capable of living in extreme climatic conditions without any adequate clothing. However, the mechanisms of their ext…
View article: In vivo response to an oral fat load of ectopic lipids and acetylcarnitine in skeletal muscle in subjects with obesity
In vivo response to an oral fat load of ectopic lipids and acetylcarnitine in skeletal muscle in subjects with obesity Open
View article: Factors Associated with SARS-CoV-2 Infection Risk among Healthcare Workers of an Italian University Hospital
Factors Associated with SARS-CoV-2 Infection Risk among Healthcare Workers of an Italian University Hospital Open
We report the results of a study on the cumulative incidence of SARS-CoV-2 infections in about 6000 workers of the University Hospital of Modena, Northern Italy, in the period March 2020–January 2021, and the relations with some individual…
View article: Health and Social Inequalities in Women Living in Disadvantaged Conditions: A Focus on Gynecologic and Obstetric Health and Intimate Partner Violence
Health and Social Inequalities in Women Living in Disadvantaged Conditions: A Focus on Gynecologic and Obstetric Health and Intimate Partner Violence Open
Purpose: Gynecologic and obstetric health and intimate partner violence are particularly influenced by social determinants of health, such as poverty, low education, and poor nutritional status, and by ethnic and racial factors. In …
View article: Bone Density and Genomic Analysis Unfold Cold Adaptation Mechanisms of Extinct Inhabitants of Tierra Del Fuego
Bone Density and Genomic Analysis Unfold Cold Adaptation Mechanisms of Extinct Inhabitants of Tierra Del Fuego Open
The Fuegians, extinct inhabitants of Tierra del Fuego, were an exemplary case of a cold-adapted population capable of living in extreme weather conditions without any adequate clothing, however the mechanisms of their extraordinary resista…