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View article: Impact of comorbidities on survival in melanoma patients
Impact of comorbidities on survival in melanoma patients Open
Comorbidity class has a significant effect on the survival of CM patients. The incorporation of the comorbidity profile into clinical care strategies can improve prognostic accuracy and enhance patient management.
View article: Systemic and locoregional therapies for cutaneous metastases from breast cancer: state of art and new frontiers in treatment approach
Systemic and locoregional therapies for cutaneous metastases from breast cancer: state of art and new frontiers in treatment approach Open
Cutaneous metastases from breast cancer, although relatively uncommon, represent the most frequent form of skin metastases overall and pose a significant clinical and therapeutic challenge. Their presence classifies the disease as stage IV…
View article: Healthcare costs of cutaneous melanoma according to comorbidity patterns: a population-based study from the Regional Cancer Registry of the Veneto Region
Healthcare costs of cutaneous melanoma according to comorbidity patterns: a population-based study from the Regional Cancer Registry of the Veneto Region Open
Background Cutaneous malignant melanoma represents a notable public health issue, characterized by a rapidly increasing incidence, particularly among younger populations. Despite progress in early detection and treatment modalities, this r…
View article: MDM2 in Tumor Biology and Cancer Therapy: A Review of Current Clinical Trials
MDM2 in Tumor Biology and Cancer Therapy: A Review of Current Clinical Trials Open
The Murine Double Minute 2 (MDM2) gene encodes an E3 ubiquitin ligase that negatively regulates the tumor suppressor p53, maintaining low p53 levels through ubiquitination and proteasomal degradation. MDM2 overexpression in various maligna…
View article: The Role of Electrochemotherapy in Managing Cutaneous Metastases from Breast Carcinoma: A Narrative Review
The Role of Electrochemotherapy in Managing Cutaneous Metastases from Breast Carcinoma: A Narrative Review Open
Cutaneous metastases from breast carcinoma represent a debilitating complication of advanced disease progression, significantly impacting patients’ quality of life. Electrochemotherapy (ECT), which combines cytotoxic drugs such as bleomyci…
View article: Solitary fibrous tumour: histological discoveries, behavioural aspects, risk assessment and therapeutical approaches
Solitary fibrous tumour: histological discoveries, behavioural aspects, risk assessment and therapeutical approaches Open
Solitary fibrous tumours (SFT) are fibroblastic mesenchymal tumours that can develop virtually at any site. It usually affects adults, and its incidence is estimated as 1 new case per million people per year. SFT is characterized by a gene…
View article: Molecular Basis of BRAF Inhibitor Resistance in Melanoma: A Systematic Review
Molecular Basis of BRAF Inhibitor Resistance in Melanoma: A Systematic Review Open
Background: Melanoma, the deadliest human skin cancer, frequently harbors activating BRAF mutations, with V600E being the most prevalent. These alterations drive constitutive activation of the MAPK pathway, promoting uncontrolled cell prol…
View article: Is the incidence of early‐onset cancers increasing in the northeast of Italy? A 30‐year analysis of the regional cancer registration data by age, 1987–2019
Is the incidence of early‐onset cancers increasing in the northeast of Italy? A 30‐year analysis of the regional cancer registration data by age, 1987–2019 Open
The analysis of cancer incidence trends in adolescents and young adults reveals a concerning increase. This observational study aims to investigate cancer incidence trends among young adults under 50, compared to older age trends, using th…
View article: Wound Healing Complication in Radio‐Treated Limb Soft Tissue Sarcoma Patients: A Single Referral Centre Experience
Wound Healing Complication in Radio‐Treated Limb Soft Tissue Sarcoma Patients: A Single Referral Centre Experience Open
Radiotherapy is recommended for G2‐G3 large soft tissue sarcoma in association with radical wide excision in order to improve the local control of disease, but side‐effects may develop early after radiation invalidating wound healing. We r…
View article: Diagnostic challenges and importance of early multidisciplinary intervention in acral melanoma: a case report
Diagnostic challenges and importance of early multidisciplinary intervention in acral melanoma: a case report Open
Acral melanoma (AM) is a rare subtype of melanoma that occurs on acral sites such as the palms, soles, and subungual regions. Due to its atypical presentation and frequent lack of pigmentation in the amelanotic variant (AAM), diagnosis is …
View article: Excision margins and prognosis in cutaneous melanoma: retrospective population-based cohort study
Excision margins and prognosis in cutaneous melanoma: retrospective population-based cohort study Open
Background The impact of surgical excision margin size on the survival of patients with cutaneous melanoma (CM) is controversial. The aim of this study was to assess the impact of excision margins on patient outcomes. Methods This retrospe…
View article: A model workflow for microfluidic enrichment and genetic analysis of circulating melanoma cells
A model workflow for microfluidic enrichment and genetic analysis of circulating melanoma cells Open
Circulating melanoma cells (CMCs) are responsible for the hematogenous spread of melanoma and, ultimately, metastasis. However, their study has been limited by the low abundance in patient blood and the heterogeneous expression of surface …
View article: Anti-CTLA-and anti-PD-1 immune checkpoint inhibitor antibodies impair human sperm motility in-vitro
Anti-CTLA-and anti-PD-1 immune checkpoint inhibitor antibodies impair human sperm motility in-vitro Open
Background Immune checkpoint inhibitors (ICIs), namely, anti-cytotoxic T lymphocyte-associated protein 4 (CTLA-4) monoclonal antibody Ipilimumab and anti- and programmed cell death 1 (PD-1) monoclonal antibodies Nivolumab, and Pembrolizuma…
View article: A real-world direct cost associated with a 4-year postdiagnosis follow-up in a population-based cohort of patients with melanoma by clinical–pathological characteristics
A real-world direct cost associated with a 4-year postdiagnosis follow-up in a population-based cohort of patients with melanoma by clinical–pathological characteristics Open
In times of limited resources, data on the costs of disease should be one of the primary factors assisting policymakers in attaining the best value for money. This study aimed to analyze the real-world direct costs associated with a 4-year…
View article: Cutaneous Nevoid Melanoma: A Retrospective Study on Clinico-Pathological Characteristics, with a Focus on Dermoscopic Features and Survival Analysis
Cutaneous Nevoid Melanoma: A Retrospective Study on Clinico-Pathological Characteristics, with a Focus on Dermoscopic Features and Survival Analysis Open
Background: Diagnosis of nevoid melanoma (NeM) is often difficult because NeM closely resembles a common nevus clinically and histologically. Methods: A retrospective study was conducted on 110 patients diagnosed with and/or treated for pr…
View article: Electrochemotherapy Treatment in a Patient with an Extended Basal Cell Carcinoma of the Face: A Case Report
Electrochemotherapy Treatment in a Patient with an Extended Basal Cell Carcinoma of the Face: A Case Report Open
Background. Basal cell carcinomas (BCCs) are common human malignancies with a rising incidence in recent years. While BCCs have a low mortality rate, they are often associated with significant local skin damage characterized by erythema, s…
View article: Therapeutic Treatment Options for In-Transit Metastases from Melanoma
Therapeutic Treatment Options for In-Transit Metastases from Melanoma Open
In-transit metastases (ITM) in melanoma present a significant therapeutic challenge due to their advanced stage and complex clinical nature. From traditional management with surgical resection, ITM treatment has evolved with the advent of …
View article: Sentinel Lymph Node Biopsy in Atypical Spitz Tumor: A Systematic Review
Sentinel Lymph Node Biopsy in Atypical Spitz Tumor: A Systematic Review Open
Background: Atypical Spitz tumor (AST) is an intermediate category among Spitz melanocytic neoplasms. Sentinel node biopsy (SNB) has been proposed in the clinical management of AST patients, but this approach remains the subject of debate.…
View article: Cutaneous melanoma in adolescents and young adults
Cutaneous melanoma in adolescents and young adults Open
Background Cutaneous malignant melanoma (CMM) ranks among the five most common cancers in young people in high‐income countries and it features peculiar clinicopathological traits. Very few studies have addressed the quality of care and th…
View article: Isolated Limb Perfusion and Immunotherapy in the Treatment of In-Transit Melanoma Metastases: Is It a Real Synergy?
Isolated Limb Perfusion and Immunotherapy in the Treatment of In-Transit Melanoma Metastases: Is It a Real Synergy? Open
Background: Isolated limb hyperthermic-antiblastic perfusion (ILP) was the most effective local treatment for advanced in-transit melanoma, but the advent of modern effective immunotherapy (IT), such as immune checkpoint inhibitors, has ch…
View article: Could the mitotic count improve personalized prognosis in melanoma patients?
Could the mitotic count improve personalized prognosis in melanoma patients? Open
A number of studies have indicated that the mitotic rate may be a predictive factor for poor prognosis in melanoma patients. The aim of this study was to investigate whether the mitotic rate is associated with other prognostic clinical and…