Simone N. De Luca
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View article: Cognitive dysfunction and its association with inflammation in acute exacerbations of COPD: protocol for a prospective hospital-based cohort
Cognitive dysfunction and its association with inflammation in acute exacerbations of COPD: protocol for a prospective hospital-based cohort Open
Introduction Chronic obstructive pulmonary disease (COPD) is characterised by progressive airflow limitation that is not fully reversible and is associated with an abnormal inflammatory response of lungs to noxious particles and gases. The…
View article: Understanding Comorbidities of Respiratory Models as Novel Platforms for Drug Discovery
Understanding Comorbidities of Respiratory Models as Novel Platforms for Drug Discovery Open
Chronic respiratory diseases affect over 450 million people worldwide and result in 4 million deaths per year. The majority of lung diseases are treated with drugs delivered directly to the lungs. However, there is bidirectional crosstalk …
View article: Apocynin Prevents Cigarette Smoke-Induced Anxiety-Like Behavior and Preserves Microglial Profiles in Male Mice
Apocynin Prevents Cigarette Smoke-Induced Anxiety-Like Behavior and Preserves Microglial Profiles in Male Mice Open
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death globally and is primarily caused by cigarette smoking (CS). Neurocognitive comorbidities such as anxiety and cognitive impairments are common among people wit…
View article: Brain region-specific alterations in gene expression trajectories in the offspring born from influenza A virus infected mice
Brain region-specific alterations in gene expression trajectories in the offspring born from influenza A virus infected mice Open
Influenza A virus (IAV) infection during pregnancy can increase the risk for neurodevelopmental disorders in the offspring, however, the underlying neurobiological mechanisms are largely unknown. To recapitulate viral infection, preclinica…
View article: Targeting accelerated pulmonary ageing to treat chronic obstructive pulmonary disease‐induced neuropathological comorbidities
Targeting accelerated pulmonary ageing to treat chronic obstructive pulmonary disease‐induced neuropathological comorbidities Open
Abstact Chronic obstructive pulmonary disease (COPD) is a major incurable health burden, ranking as the third leading cause of death worldwide, mainly driven by cigarette smoking. COPD is characterised by persistent airway inflammation, lu…
View article: Calorie restriction partially attenuates sickness behavior induced by viral mimetic poly I:C
Calorie restriction partially attenuates sickness behavior induced by viral mimetic poly I:C Open
View article: Targeting accelerated pulmonary ageing to treat COPD induced neuropathological comorbidities.
Targeting accelerated pulmonary ageing to treat COPD induced neuropathological comorbidities. Open
Chronic Obstructive Pulmonary Disease (COPD) is a major incurable health burden, ranking as the 3rd leading cause of death worldwide, mainly driven by cigarette smoking. COPD is characterised by persistent airway inflammation, lung functio…
View article: Ginsenosides enhance P2X7-dependent cytokine secretion from LPS-primed rodent macrophages
Ginsenosides enhance P2X7-dependent cytokine secretion from LPS-primed rodent macrophages Open
The activation of P2X7 is a well-known stimulus for the NLRP3-caspase 1 inflammasome and subsequent rapid IL-1β secretion from monocytes and macrophages. Here we show that positive allosteric modulators of P2X7, ginsenosides, can enhance t…
View article: Inhibition of oxidative stress by apocynin attenuated chronic obstructive pulmonary disease progression and vascular injury by cigarette smoke exposure
Inhibition of oxidative stress by apocynin attenuated chronic obstructive pulmonary disease progression and vascular injury by cigarette smoke exposure Open
Background and Purpose Cardiovascular disease affects up to half of the patients with chronic obstructive pulmonary disease (COPD), exerting deleterious impact on health outcomes and survivability. Vascular endothelial dysfunction marks th…
View article: Cigarette smoke-induced pulmonary impairment is associated with social recognition memory impairments and alterations in microglial profiles within the suprachiasmatic nucleus of the hypothalamus
Cigarette smoke-induced pulmonary impairment is associated with social recognition memory impairments and alterations in microglial profiles within the suprachiasmatic nucleus of the hypothalamus Open
Chronic obstructive pulmonary disease (COPD) is a major, incurable respiratory condition that is primarily caused by cigarette smoking (CS). Neurocognitive disorders including cognitive dysfunction, anxiety and depression are highly preval…
View article: Inhibition of oxidative stress by apocynin attenuated COPD progression and vascular injury by cigarette smoke exposure
Inhibition of oxidative stress by apocynin attenuated COPD progression and vascular injury by cigarette smoke exposure Open
Background and Purpose: Cardiovascular disease (CVD) affects up to half of the patients with chronic obstructive pulmonary disease (COPD), which exerts deleterious impact on health outcomes and survivability. Vascular endothelial dysfuncti…
View article: Cigarette Smoke Exposure Induces Neurocognitive Impairments and Neuropathological Changes in the Hippocampus
Cigarette Smoke Exposure Induces Neurocognitive Impairments and Neuropathological Changes in the Hippocampus Open
Background and Objective Neurocognitive dysfunction is present in up to ∼61% of people with chronic obstructive pulmonary disease (COPD), with symptoms including learning and memory deficiencies, negatively impacting the quality of life of…
View article: Ebselen prevents cigarette smoke-induced cognitive dysfunction in mice by preserving hippocampal synaptophysin expression
Ebselen prevents cigarette smoke-induced cognitive dysfunction in mice by preserving hippocampal synaptophysin expression Open
Background Cigarette smoking (CS) is the leading cause of chronic obstructive pulmonary disease (COPD). The “spill-over” of pulmonary inflammation into the systemic circulation may damage the brain, leading to cognitive dysfunction. Cessat…
View article: Influenza A Virus-Driven Airway Inflammation may be Dissociated From Limb Muscle Atrophy in Cigarette Smoke-Exposed Mice
Influenza A Virus-Driven Airway Inflammation may be Dissociated From Limb Muscle Atrophy in Cigarette Smoke-Exposed Mice Open
Limb muscle dysfunction is a hallmark of Chronic Obstructive Pulmonary Disease (COPD) which is further worsened following a viral-induced acute exacerbation of COPD (AECOPD). An amplified airway inflammation underlies the aggravated respir…
View article: Ebselen Prevents Cigarette Smoke-Induced Cognitive Dysfunction In Mice By Preserving Hippocampal Synaptophysin Expression
Ebselen Prevents Cigarette Smoke-Induced Cognitive Dysfunction In Mice By Preserving Hippocampal Synaptophysin Expression Open
Background: Cigarette smoking (CS) is the leading cause of chronic obstructive pulmonary disease (COPD). The “spill-over” of pulmonary inflammation into the systemic circulation may damage the brain, leading to cognitive dysfunction. Cessa…
View article: Ebselen abolishes vascular dysfunction in influenza A virus-induced exacerbations of cigarette smoke-induced lung inflammation in mice
Ebselen abolishes vascular dysfunction in influenza A virus-induced exacerbations of cigarette smoke-induced lung inflammation in mice Open
Background and Purpose: People with COPD are susceptible to respiratory infections which exacerbate pulmonary and/or cardiovascular complications, increasing their likelihood of death. The mechanisms driving these complications remain unkn…
View article: Novel pharmacological strategies to treat cognitive dysfunction in chronic obstructive pulmonary disease
Novel pharmacological strategies to treat cognitive dysfunction in chronic obstructive pulmonary disease Open
Chronic obstructive pulmonary disease (COPD) is a major incurable global health burden and currently the 3rd largest cause of death in the world, with approximately 3.23 million deaths per year. Globally, the financial burden of COPD is ap…
View article: Apocynin prevents cigarette smoking‐induced loss of skeletal muscle mass and function in mice by preserving proteostatic signalling
Apocynin prevents cigarette smoking‐induced loss of skeletal muscle mass and function in mice by preserving proteostatic signalling Open
Background and Purpose Skeletal muscle dysfunction is a major comorbidity of chronic obstructive pulmonary disease (COPD). This type of muscle dysfunction may be a direct consequence of oxidative insults evoked by cigarette smoke (CS) expo…
View article: Ebselen prevents cigarette smoke-induced gastrointestinal dysfunction in mice
Ebselen prevents cigarette smoke-induced gastrointestinal dysfunction in mice Open
Gastrointestinal (GI) dysfunction is a common comorbidity of chronic obstructive pulmonary disease (COPD) for which a major cause is cigarette smoking (CS). The underlying mechanisms and precise effects of CS on gut contractility, however,…
View article: Apocynin prevents cigarette smoking-induced loss of skeletal muscle mass and function by preserving proteostatic signalling
Apocynin prevents cigarette smoking-induced loss of skeletal muscle mass and function by preserving proteostatic signalling Open
Background and Purpose: Cigarette smoking (CS) is the major risk factor for developing COPD and related skeletal muscle dysfunction. It has been postulated that CS exposure may directly causes muscle dysfunction via the induction of oxidat…
View article: Antioxidant Treatment Prevents Cigarette Smoke Induced Hippocampal-Dependent Cognitive Impairment in the Mouse
Antioxidant Treatment Prevents Cigarette Smoke Induced Hippocampal-Dependent Cognitive Impairment in the Mouse Open
View article: Ebselen Prevents Vascular Endothelial Dysfunction in Viral-Induced Exacerbations of Chronic Obstructive Pulmonary Disease
Ebselen Prevents Vascular Endothelial Dysfunction in Viral-Induced Exacerbations of Chronic Obstructive Pulmonary Disease Open
View article: Glial remodeling enhances short-term memory performance in Wistar rats
Glial remodeling enhances short-term memory performance in Wistar rats Open
View article: Chronic predator stress in female mice reduces primordial follicle numbers: implications for the role of ghrelin
Chronic predator stress in female mice reduces primordial follicle numbers: implications for the role of ghrelin Open
Chronic stress is a known suppressor of female reproductive function. However, attempts to isolate single causal links between stress and reproductive dysfunction have not yet been successful due to their multi-faceted aetiologies. The gut…
View article: Effects of exercise on adolescent and adult hypothalamic and hippocampal neuroinflammation
Effects of exercise on adolescent and adult hypothalamic and hippocampal neuroinflammation Open
Published in Hippocampus 26:1435–1446 (2016) DOI: 10.1002/hipo22620 The authors of this article have notified us that one of the funding agencies was incorrectly acknowledged. The correct citation of the funding body is listed below: This …
View article: Hyperleptinemia in Neonatally Overfed Female Rats Does Not Dysregulate Feeding Circuitry
Hyperleptinemia in Neonatally Overfed Female Rats Does Not Dysregulate Feeding Circuitry Open
Neonatal overfeeding during the first weeks of life in male rats is associated with a disruption in the peripheral and central leptin systems. Neonatally overfed male rats have increased circulating leptin in the first 2 weeks of life, whi…
View article: Neonatal overfeeding by small‐litter rearing sensitises hippocampal microglial responses to immune challenge: Reversal with neonatal repeated injections of saline or minocycline
Neonatal overfeeding by small‐litter rearing sensitises hippocampal microglial responses to immune challenge: Reversal with neonatal repeated injections of saline or minocycline Open
The early‐life period is extremely vulnerable to programming effects from the environment, many of which persist into adulthood. We have previously demonstrated that adult rats overfed as neonates have hypothalamic microglia that are hyper…
View article: Ghrelin and hypothalamic NPY/AgRP expression in mice are affected by chronic early-life stress exposure in a sex-specific manner
Ghrelin and hypothalamic NPY/AgRP expression in mice are affected by chronic early-life stress exposure in a sex-specific manner Open
View article: Cover Image, Volume 26, Issue 11
Cover Image, Volume 26, Issue 11 Open
Cover legend: This cover image, by Sarah J. Spencer et al., is based on the Research Article Effects of exercise on adolescent and adult hypothalamic and hippocampal neuroinflammation, DOI: 10.1002/hipo.22620.
View article: Early life overfeeding impairs spatial memory performance by reducing microglial sensitivity to learning
Early life overfeeding impairs spatial memory performance by reducing microglial sensitivity to learning Open
Thus, early life overfeeding contributes to a long-term impairment in learning and memory with a likely role for microglia. These data may partially explain why some obese individuals display cognitive dysfunction and some do not, i.e. the…