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View article: The human pathogen, Schistosoma mansoni, lacks the cognate sequence for human telomerase reverse transcriptase (hTERT) and relies on the snail host, Biomphalaria glabrata homologous enzyme for its intra-molluscan development.
The human pathogen, Schistosoma mansoni, lacks the cognate sequence for human telomerase reverse transcriptase (hTERT) and relies on the snail host, Biomphalaria glabrata homologous enzyme for its intra-molluscan development. Open
The human telomerase reverse transcriptase (hTERT) is the catalytic sub-unit of the ribonuclear protein, telomerase. Together with telomerase RNA, the enzyme complex participates in the maintenance of telomeres at the proximal ends of chro…
View article: Inhibition of Carbonic Anhydrase Using Aspirin is a Novel Method to Block Schistosomiasis Infection of the Parasitic Trematode,<i>Schistosoma mansoni,</i>in the intermediate snail host,<i>Biomphalaria glabrata</i>
Inhibition of Carbonic Anhydrase Using Aspirin is a Novel Method to Block Schistosomiasis Infection of the Parasitic Trematode,<i>Schistosoma mansoni,</i>in the intermediate snail host,<i>Biomphalaria glabrata</i> Open
Schistosomiasis is a major public health concern worldwide. Although praziquantel is currently available as the only treatment option for schistosomiasis, the absence of reliable diagnostic and prognostic tools highlights the need for the …
View article: RNASeq profiling of COVID19‐infected patients identified an EIF2AK2 inhibitor as a potent SARS‐CoV‐2 antiviral
RNASeq profiling of COVID19‐infected patients identified an EIF2AK2 inhibitor as a potent SARS‐CoV‐2 antiviral Open
Dear Editor, In this study, we found gene expression changes in key genes involved in activating immune pathways and genes targeted by SARS-CoV-2 to interfere with normal host cell functioning. Notably, critical changes have been observed …
View article: SARS-CoV-2 Omicron (BA.1 and BA.2) specific novel CD8+ and CD4+ T cell epitopes targeting spike protein
SARS-CoV-2 Omicron (BA.1 and BA.2) specific novel CD8+ and CD4+ T cell epitopes targeting spike protein Open
The Omicron (BA.1/B.1.1.529) variant of SARS-CoV-2 harbors an alarming 37 mutations on its spike protein, reducing the efficacy of current COVID-19 vaccines. This study identified CD8+ and CD4+ T cell epitopes from SARS-CoV-2 S protein mut…
View article: Design of Peptide Vaccine for COVID19: CD8+ and CD4+ T cell epitopes from SARS-CoV-2 open-reading-frame protein variants
Design of Peptide Vaccine for COVID19: CD8+ and CD4+ T cell epitopes from SARS-CoV-2 open-reading-frame protein variants Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, has challenged public health at an unprecedented scale which has led to a dramatic loss of human life worldwide. To design a protective vaccine …