Simone Pernice
YOU?
Author Swipe
View article: UnifiedGreatMod: a new holistic modelling paradigm for studying biological systems on a complete and harmonious scale
UnifiedGreatMod: a new holistic modelling paradigm for studying biological systems on a complete and harmonious scale Open
Motivation Computational models are crucial for addressing critical questions about systems evolution and deciphering system connections. The pivotal feature of making this concept recognizable from the biological and clinical community is…
View article: <i>UnifiedGreatMod</i>: A New Holistic Modeling Paradigm for Studying Biological Systems on a Complete and Harmonious Scale
<i>UnifiedGreatMod</i>: A New Holistic Modeling Paradigm for Studying Biological Systems on a Complete and Harmonious Scale Open
Motivation Computational models are crucial for addressing critical questions about systems evolution and deciphering system connections. The pivotal feature of making this concept recognisable from the biological and clinical community is…
View article: PHeP: TrustAlert Open-Source Platform for Enhancing Predictive Healthcare with Deep Learning
PHeP: TrustAlert Open-Source Platform for Enhancing Predictive Healthcare with Deep Learning Open
Predictive healthcare, a field revolutionized by the availability of large medical datasets and computational advancements, plays a pivotal role in enhancing patient care and healthcare system performance. Despite its significance, the tra…
View article: A new computational workflow to guide personalized drug therapy
A new computational workflow to guide personalized drug therapy Open
GreatNectoranalysis was able to stratify individual patients into three model meta-patients whose dynamics suggested insight into patient-tailored interventions.
View article: OmniReprodubileCellAnalysis: a comprehensive toolbox for the analysis of cellular biology data
OmniReprodubileCellAnalysis: a comprehensive toolbox for the analysis of cellular biology data Open
Open science and reproducibility are two key pillars of modern scientific research. Open science is making scientific research and data accessible and transparent to the broader scientific community and the public. Reproducibility, on the …
View article: MODIMO: Workshop on Multi-Omics Data Integration for Modelling Biological Systems
MODIMO: Workshop on Multi-Omics Data Integration for Modelling Biological Systems Open
Multi-omics analysis aims at extracting previously uncovered biological knowledge by integrating information across multiple single-omic sources. Past approaches have focused on the simultaneous analysis of a small number of omic data sets…
View article: CONNECTOR, fitting and clustering of longitudinal data to reveal a new risk stratification system
CONNECTOR, fitting and clustering of longitudinal data to reveal a new risk stratification system Open
Motivation The transition from evaluating a single time point to examining the entire dynamic evolution of a system is possible only in the presence of the proper framework. The strong variability of dynamic evolution makes the definition …
View article: How the Competition for Cysteine May Promote Infection of SARS-CoV-2 by Triggering Oxidative Stress
How the Competition for Cysteine May Promote Infection of SARS-CoV-2 by Triggering Oxidative Stress Open
SARS-CoV-2 induces a broad range of clinical manifestations. Besides the main receptor, ACE2, other putative receptors and co-receptors have been described and could become genuinely relevant to explain the different tropism manifested by …
View article: Biochemical analysis
Biochemical analysis Open
Biochemical analysis of similarities between human and SARS-CoV-2 proteins
View article: Biochemical analysis
Biochemical analysis Open
Biochemical analysis of similarities between human and SARS-CoV-2 proteins
View article: CONNECTOR, fitting and clustering of longitudinal data to reveal a new risk stratification system
CONNECTOR, fitting and clustering of longitudinal data to reveal a new risk stratification system Open
The transition from the evaluation of a single time point to the examination of the entire dynamic evolution of a system is possible only in the presence of the proper framework. The strong variability of dynamic evolution makes the defini…
View article: An Agent-Based Model to Support Infection Control Strategies at School
An Agent-Based Model to Support Infection Control Strategies at School Open
Many governments enforced physical distancing measures during the COVID-19 pandemic to avoid the collapse of often fragile and overloaded health care systems.Following the physical distancing measures, school closures seemed unavoidable to…
View article: Impacts of reopening strategies for COVID-19 epidemic: a modeling study in Piedmont region
Impacts of reopening strategies for COVID-19 epidemic: a modeling study in Piedmont region Open
Background Severe acute respiratory syndrome coronavirus 2 (SARS-COV-2), the causative agent of the coronavirus disease 19 (COVID-19), is a highly transmittable virus. Since the first person-to-person transmission of SARS-CoV-2 was reporte…
View article: Impacts of Reopening Strategies for COVID-19 Epidemic: A Modeling Study in Piedmont Region
Impacts of Reopening Strategies for COVID-19 Epidemic: A Modeling Study in Piedmont Region Open
Background Severe acute respiratory syndrome coronavirus 2 (SARS-COV-2), the causative agent of the coronavirus disease 19 (COVID-19), is a highly transmittable virus. Since the first person-to-person transmission of SARS-CoV-2 was reporte…
View article: Impacts of Reopening Strategies for COVID-19 Epidemic: A Modeling Study in Piedmont Region
Impacts of Reopening Strategies for COVID-19 Epidemic: A Modeling Study in Piedmont Region Open
Background Severe acute respiratory syndrome coronavirus 2 (SARS-COV-2), the causative agent of the coronavirus disease 19 (COVID-19), is a highly transmittable virus. Since the first person-to-person transmission of SARS-CoV-2 was reporte…
View article: Exploiting Stochastic Petri Net formalism to capture the Relapsing Remitting Multiple Sclerosis variability under Daclizumab administration
Exploiting Stochastic Petri Net formalism to capture the Relapsing Remitting Multiple Sclerosis variability under Daclizumab administration Open
It is well known that the response of individuals to disease varies, either because of unpredictable exogenous events, such as possibly unknown environmental effects, or just because of endogenous factors, i.e. different genetic background…
View article: MethylFASTQ: A Tool Simulating Bisulfite Sequencing Data
MethylFASTQ: A Tool Simulating Bisulfite Sequencing Data Open
DNA methylation is a DNA modification playing an important role in several diseases, including cancer. The gold-standard technique for measuring DNA methylation is Bisulfite Sequencing (BS). The treatment with bisulfite alters the sequence…
View article: CONNECTOR, fitting and clustering of longitudinal data. v1
CONNECTOR, fitting and clustering of longitudinal data. v1 Open
The transition from the evaluation of a single time point to the examination of the entire dynamic evolution of a system is possible only in the presence of the proper framework. The strong variability of dynamic evolution makes the defini…
View article: ParallNormal: An Efficient Variant Calling Pipeline for Unmatched Sequencing Data
ParallNormal: An Efficient Variant Calling Pipeline for Unmatched Sequencing Data Open
Nowadays, next generation sequencing is closer to clinical application in the field of oncology. Indeed, it allows the identification of tumor-specific mutations acquired during cancer development, progression and resistance to therapy. In…