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View article: Methylthio-alkane reductases use nitrogenase metalloclusters for carbon–sulfur bond cleavage
Methylthio-alkane reductases use nitrogenase metalloclusters for carbon–sulfur bond cleavage Open
Methylthio-alkane reductases convert methylated sulfur compounds to methanethiol and small hydrocarbons, a process with important environmental and biotechnological implications. These enzymes are classified as nitrogenase-like enzymes, de…
View article: Methylthio-alkane reductases use nitrogenase metalloclusters for carbon-sulfur bond cleavage
Methylthio-alkane reductases use nitrogenase metalloclusters for carbon-sulfur bond cleavage Open
Methylthio-alkane reductases convert methylated sulfur compounds to methanethiol and small hydrocarbons, a process with important environmental and biotechnological implications. These enzymes are classified as nitrogenase-like enzymes, de…
View article: Bottom-up reconstruction of minimal pyrenoids provides insights into the evolution and mechanisms of carbon concentration by EPYC1 proteins
Bottom-up reconstruction of minimal pyrenoids provides insights into the evolution and mechanisms of carbon concentration by EPYC1 proteins Open
Summary Membraneless organelles play essential roles in cellular processes. In various photosynthetic organisms, they confer carbon concentrating mechanisms (CCMs). One example is the pyrenoid in Chlamydomonas reinhardtii , a liquid-phase …
View article: Machine Learning-Supported Enzyme Engineering toward Improved CO<sub>2</sub>-Fixation of Glycolyl-CoA Carboxylase
Machine Learning-Supported Enzyme Engineering toward Improved CO<sub>2</sub>-Fixation of Glycolyl-CoA Carboxylase Open
Glycolyl-CoA carboxylase (GCC) is a new-to-nature enzyme that catalyzes the key reaction in the tartronyl-CoA (TaCo) pathway, a synthetic photorespiration bypass that was recently designed to improve photosynthetic CO2 fixation. GCC was cr…
View article: A bacterial tungsten-containing aldehyde oxidoreductase forms an enzymatic decorated protein nanowire
A bacterial tungsten-containing aldehyde oxidoreductase forms an enzymatic decorated protein nanowire Open
Aldehyde oxidoreductases (AORs) are tungsten enzymes catalyzing the oxidation of many different aldehydes to the corresponding carboxylic acids. In contrast to other known AORs, the enzyme from the denitrifying betaproteobacterium Aromatol…
View article: Structural Insights into the Iron Nitrogenase Complex
Structural Insights into the Iron Nitrogenase Complex Open
Nitrogenases are best known for catalysing the reduction of dinitrogen to ammonia at a complex metallic cofactor. Recently, nitrogenases were shown to reduce carbon dioxide (CO 2 ) and carbon monoxide to hydrocarbons, offering a pathway to…
View article: A bacterial tungsten-containing aldehyde oxidoreductase forms an enzymatic decorated protein nanowire
A bacterial tungsten-containing aldehyde oxidoreductase forms an enzymatic decorated protein nanowire Open
Aldehyde oxidoreductases (AOR) are tungsten enzymes catalysing the oxidation of many different aldehydes to the corresponding carboxylic acids. In contrast to other known AORs, the enzyme from the denitrifying betaproteobacterium Aromatole…
View article: Structure and mechanistic features of the prokaryotic minimal RNase P
Structure and mechanistic features of the prokaryotic minimal RNase P Open
Endonucleolytic removal of 5’-leader sequences from tRNA precursor transcripts (pre-tRNAs) by ribonuclease P (RNase P) is essential for protein synthesis. Beyond RNA-based RNase P enzymes, protein-only versions of the enzyme exert this fun…
View article: Structure and mechanistic features of the prokaryotic minimal RNase P
Structure and mechanistic features of the prokaryotic minimal RNase P Open
Endonucleolytic removal of 5’-leader sequences from tRNA precursor transcripts (pre-tRNAs) by RNase P is essential for protein synthesis. Beyond RNA-based RNase P enzymes, protein-only versions of the enzyme exert this function in various …
View article: A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I
A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I Open
Significance We present a comprehensive structural study, which shows the human GCH1 and GCH1−GFRP complexes in all states (apo, ligand bound, partially and fully inhibited). We observed local rearrangements in the allosteric pocket upon B…
View article: Molecular and Low-Resolution Structural Characterization of the Na+-Translocating Glutaconyl-CoA Decarboxylase From Clostridium symbiosum
Molecular and Low-Resolution Structural Characterization of the Na+-Translocating Glutaconyl-CoA Decarboxylase From Clostridium symbiosum Open
Some anaerobic bacteria use biotin-dependent Na+-translocating decarboxylases (Bdc) of β-keto acids or their thioester analogs as key enzymes in their energy metabolism. Glutaconyl-CoA decarboxylase (Gcd), a member of this protein family, …
View article: High-resolution cryo-EM structures of respiratory complex I: Mechanism, assembly, and disease
High-resolution cryo-EM structures of respiratory complex I: Mechanism, assembly, and disease Open
Cryo-EM, yeast genetics, and simulations offer an integrated approach to assess structure, function, and assembly of complex I.
View article: Structure of the Ty3/Gypsy retrotransposon capsid and the evolution of retroviruses
Structure of the Ty3/Gypsy retrotransposon capsid and the evolution of retroviruses Open
Retroviruses evolved from long terminal repeat (LTR) retrotransposons by acquisition of envelope functions, and subsequently reinvaded host genomes. Together, endogenous retroviruses and LTR retrotransposons represent major components of a…
View article: A 192-heme electron transfer network in the hydrazine dehydrogenase complex
A 192-heme electron transfer network in the hydrazine dehydrogenase complex Open
A protein complex key to the global nitrogen cycle has an unprecedented electron transport network of 192 heme groups.
View article: Gating of Acoustic Transducer Channels Is Shaped by Biomechanical Filter Processes
Gating of Acoustic Transducer Channels Is Shaped by Biomechanical Filter Processes Open
Mechanoelectrical transduction of acoustic signals is the fundamental process for hearing in all ears across the animal kingdom. Here, we performed in vivo laser-vibrometric and electrophysiological measurements at the transduction site in…