Simone Scalise
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View article: Robust assessment of asymmetric division in colon cancer cells
Robust assessment of asymmetric division in colon cancer cells Open
Asymmetric partition of fate determinants during cell division is a hallmark of cell differentiation. Recent work suggested that such a mechanism is hijacked by cancer cells to increase both their phenotypic heterogeneity and plasticity an…
View article: A mother-machine microfluidic device for non-adherent mammalian cells reveals the population growth strategies
A mother-machine microfluidic device for non-adherent mammalian cells reveals the population growth strategies Open
We develop a mother machine-like microfluidic device specifically designed to track the proliferation of T-cells via live-cell microscopy. Although numerous microfluidic setups have been developed to study cell proliferation at the single-…
View article: Robust assessment of asymmetric division in colon cancer cells
Robust assessment of asymmetric division in colon cancer cells Open
Asymmetric partition of fate determinants during cell division is a hallmark of cell differentiation. Recent work suggested that such a mechanism is hijacked by cancer cells to increase both their phenotypic heterogeneity and plasticity an…
View article: Robust assessment of asymmetric division in colon cancer cells
Robust assessment of asymmetric division in colon cancer cells Open
Asymmetric partition of fate determinants during cell division is a hallmark of cell differentiation. Recent works suggested that such a mechanism is hijacked by cancer cells to increase both their phenotypic heterogeneity and plasticity a…
View article: Robust assessment of asymmetric division in colon cancer cells
Robust assessment of asymmetric division in colon cancer cells Open
Asymmetric partition of fate determinants during cell division is a hallmark of cell differentiation. Recent work suggested that such a mechanism is hijacked by cancer cells to increase both their phenotypic heterogeneity and plasticity an…
Probing leukemia cells behavior under starvation Open
The ability of a cancer cell population to achieve heterogeneity in their phenotype distributions offers advantages in tumor invasiveness and drug resistance. Studying the mechanisms behind such observed heterogeneity in mammalian cells pr…
A size-dependent division strategy accounts for leukemia cell size heterogeneity Open
Heterogeneity in the size distribution of cancer cell populations is linked to drug resistance and invasiveness. However, understanding how such heterogeneity arises is still damped by the difficulties of monitoring the proliferation at th…
Determining cancer cells division strategy Open
Heterogeneity in the size distribution of cancer cell populations has been recently linked to drug resistance and invasiveness. However, despite many progresses have been made in understanding how such heterogeneous size distributions aris…