Simone Steinbach
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View article: The Aging Substantia Nigra is Characterized by ROS Accumulation Potentially Resulting in Increased Neuroinflammation and Cytoskeletal Remodeling
The Aging Substantia Nigra is Characterized by ROS Accumulation Potentially Resulting in Increased Neuroinflammation and Cytoskeletal Remodeling Open
Aging is a progressive and irreversible process, serving as the primary risk factor for neurodegenerative disorders. This study aims to identify the molecular mechanisms underlying physiological aging within the substantia nigra , which is…
View article: Don’t die like me: Which proteins are responsible for the selective neuronal vulnerability within the substantia nigra?
Don’t die like me: Which proteins are responsible for the selective neuronal vulnerability within the substantia nigra? Open
A hallmark of Parkinson’s disease is the specific degeneration of dopaminergic neurons in the substantia nigra pars compacta . Interestingly, not all of these neurons are affected to the same extent. Studies revealed that neurons located m…
View article: Mid-regional pro-adrenomedullin and lactate levels for risk stratification in patients with out-of-hospital cardiac arrest
Mid-regional pro-adrenomedullin and lactate levels for risk stratification in patients with out-of-hospital cardiac arrest Open
Aims Adrenomedullin (ADM) is a free-circulating peptide that regulates endothelial barrier function and vascular tone. Here, we sought to study the relationship of ADM in combination with lactate and the risk of death in patients with out-…
View article: Dataset containing physiological amounts of spike-in proteins into murine C2C12 background as a ground truth quantitative LC-MS/MS reference
Dataset containing physiological amounts of spike-in proteins into murine C2C12 background as a ground truth quantitative LC-MS/MS reference Open
In this article, we present a data dependent acquisition (DDA) dataset which was generated as a reference and ground truth quantitative dataset. While initially used to compare samples measured with DDA and data independent acquisition (DI…
View article: Human cerebrospinal fluid data for use as spectral library, for biomarker research
Human cerebrospinal fluid data for use as spectral library, for biomarker research Open
Spectral libraries generated by data dependent acquisition (DDA) are a useful tool for the analysis of data created by data independent acquisition (DIA) in mass spectrometry. The quality of DIA analysis is dependent on the quality of the …
View article: The microRNA miR-375-3p and the Tumor Suppressor NDRG2 are Involved in Sporadic Amyotrophic Lateral Sclerosis
The microRNA miR-375-3p and the Tumor Suppressor NDRG2 are Involved in Sporadic Amyotrophic Lateral Sclerosis Open
The present study has shown NDRG2 and miR-375-3p to be promising targets for further research of the pathogenesis of sporadic ALS in the wobbler mouse model. Based on these results and in combination with previous published data we could d…
View article: Protein variability in cerebrospinal fluid and its possible implications for neurological protein biomarker research
Protein variability in cerebrospinal fluid and its possible implications for neurological protein biomarker research Open
Cerebrospinal fluid is investigated in biomarker studies for various neurological disorders of the central nervous system due to its proximity to the brain. Currently, only a limited number of biomarkers have been validated in independent …
View article: Characterization of Cerebrospinal Fluid via Data-Independent Acquisition Mass Spectrometry
Characterization of Cerebrospinal Fluid via Data-Independent Acquisition Mass Spectrometry Open
Cerebrospinal fluid (CSF) is in direct contact with the brain and serves as a valuable specimen to examine diseases of the central nervous system through analyzing its components. These include the analysis of metabolites, cells as well as…
View article: A proteomic investigation of the ageing \(\textit {substantia nigra}\) and the selective neuronal vulnerability of its neurons
A proteomic investigation of the ageing \(\textit {substantia nigra}\) and the selective neuronal vulnerability of its neurons Open
Altern ist durch die Ansammlung von beschädigten Proteinen, beschädigter DNA, höherem oxidativem Stress und einer gestörten Energiehomöostase gekennzeichnet. Dadurch ist der Organismus anfälliger gegenüber Stress und stirbt letztendlich. O…
View article: Proteomic characterization of neuromelanin granules isolated from human substantia nigra by laser-microdissection
Proteomic characterization of neuromelanin granules isolated from human substantia nigra by laser-microdissection Open
Neuromelanin is a complex polymer pigment found primarily in the dopaminergic neurons of human substantia nigra . Neuromelanin pigment is stored in granules including a protein matrix and lipid droplets. Neuromelanin granules are yet only …