Simone Wicki
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View article: Loss of BID Delays FASL-Induced Cell Death of Mouse Neutrophils and Aggravates DSS-Induced Weight Loss
Loss of BID Delays FASL-Induced Cell Death of Mouse Neutrophils and Aggravates DSS-Induced Weight Loss Open
Neutrophils are key players in the early defense against invading pathogens. Due to their potent effector functions, programmed cell death of activated neutrophils has to be tightly controlled; however, its underlying mechanisms remain unc…
View article: BOK promotes chemical-induced hepatocarcinogenesis in mice
BOK promotes chemical-induced hepatocarcinogenesis in mice Open
View article: BH3 mimetics efficiently induce apoptosis in mouse basophils and mast cells
BH3 mimetics efficiently induce apoptosis in mouse basophils and mast cells Open
Basophil granulocytes and mast cells are recognized for their roles in immunity and are central effectors of diverse immunological disorders. Despite their similarities, there is emerging evidence for non-redundant roles of the circulating…
View article: IVIG regulates the survival of human but not mouse neutrophils
IVIG regulates the survival of human but not mouse neutrophils Open
Intravenous immunoglobulin (IVIG) are purified IgG preparations made from the pooled plasma from thousands of healthy donors and are being tested in preclinical mouse models. Inherent challenges, however, are the pluripotency of IVIG and i…
View article: Loss of XIAP facilitates switch to TNFα-induced necroptosis in mouse neutrophils
Loss of XIAP facilitates switch to TNFα-induced necroptosis in mouse neutrophils Open
View article: In vitro differentiation of mouse granulocytes. Programmed Cell Death: Methods and Protocols
In vitro differentiation of mouse granulocytes. Programmed Cell Death: Methods and Protocols Open
Granulocytes are central players of the immune system and, once activated, a tightly controlled balance between effector functions and cell removal by apoptosis guarantees maximal host benefit with least possible collateral damage to healt…
View article: NET formation can occur independently of RIPK3 and MLKL signaling
NET formation can occur independently of RIPK3 and MLKL signaling Open
The importance of neutrophil extracellular traps (NETs) in innate immunity is well established but the molecular mechanisms responsible for their formation are still a matter of scientific dispute. Here, we aim to characterize a possible r…