Simzar Hosseinzadeh
YOU?
Author Swipe
View article: Well-regulated dermal regeneration using amnion-containing scaffold in a preclinical study
Well-regulated dermal regeneration using amnion-containing scaffold in a preclinical study Open
Purpose: we investigated the synergistic influence of amnion and keratinocytes on dermal regeneration in mice. Method: A scaffold derived from amnion and gelatin via electrospinning was used to synthesize a polyurethane-based scaffold. pol…
View article: Apoptotic Impact of Heliox Cold Plasma on a Cervical Cell Line Using Gold Nanoparticle-Doped Graphene Oxide Nanosheets
Apoptotic Impact of Heliox Cold Plasma on a Cervical Cell Line Using Gold Nanoparticle-Doped Graphene Oxide Nanosheets Open
Background: Invasive cervical cancer is recognized as the second most common malignancy in women after breast cancer. Objectives: This study investigates, for the first time, the effect of gold nanoparticle-doped graphene oxide (GO) nanosh…
View article: In Vitro Comparison of PU, PU-CA, and PU-CA-GO scaffolds to evaluate osteogenic differentiation of mesenchymal stem cells
In Vitro Comparison of PU, PU-CA, and PU-CA-GO scaffolds to evaluate osteogenic differentiation of mesenchymal stem cells Open
Background Nanoscale scaffolds play a significant role in bone tissue engineering due to their appropriate biological activity which could be increased by the presence of nanoparticles such as graphene oxide (GO). This study aimed to devel…
View article: Recent advances in nanostructured delivery systems for vancomycin
Recent advances in nanostructured delivery systems for vancomycin Open
Despite the development of new generations of antibiotics, vancomycin remained as a high-efficacy antibiotic for treating the infections caused by MRSA. Researchers have explored various nanoformulations, aiming to enhance the therapeutic …
View article: Applications of extraembryonic tissue-derived cells in vascular tissue regeneration
Applications of extraembryonic tissue-derived cells in vascular tissue regeneration Open
Vascular tissue engineering is a promising approach for regenerating damaged blood vessels and developing new therapeutic approaches for heart disease treatment. To date, different sources of cells have been recognized that offer assistanc…
View article: Chitosan/Hyaluronan and Alginate-nanohydroxyapatite Biphasic Scaffold as a Promising Matrix for Osteoarthritis Disorders
Chitosan/Hyaluronan and Alginate-nanohydroxyapatite Biphasic Scaffold as a Promising Matrix for Osteoarthritis Disorders Open
Purpose: Regenerative medicine offers new techniques for osteoarthritis disorders, especially while considering simultaneous chondral and subchondral regenerations. Methods: Chitosan and hyaluronan were chemically bound as the chondral pha…
View article: Poly (acrylic acid)/tricalcium phosphate nanoparticles scaffold enriched with exosomes for cell-free therapy in bone tissue engineering: An in vivo evaluation
Poly (acrylic acid)/tricalcium phosphate nanoparticles scaffold enriched with exosomes for cell-free therapy in bone tissue engineering: An in vivo evaluation Open
Introduction: This study aimed to assess the potential of poly (acrylic acid)/tricalcium phosphate nanoparticles (PAA/triCaPNPs) scaffold in terms of biocompatibility and osteoconductivity properties the in-vivo evaluation as well as to in…
View article: Overexpression of VEGF in dermal fibroblast cells accelerates the angiogenesis and wound healing function: in vitro and in vivo studies
Overexpression of VEGF in dermal fibroblast cells accelerates the angiogenesis and wound healing function: in vitro and in vivo studies Open
Fibroblasts are the main cells of connective tissue and have pivotal roles in the proliferative and maturation phases of wound healing. These cells can secrete various cytokines, growth factors, and collagen. Vascular endothelial growth fa…
View article: Preparation of poly(acrylic acid)/tricalcium phosphate nanoparticles scaffold: Characterization and releasing UC-MSCs derived exosomes for bone differentiation
Preparation of poly(acrylic acid)/tricalcium phosphate nanoparticles scaffold: Characterization and releasing UC-MSCs derived exosomes for bone differentiation Open
Introduction: This study focused on preparing a multiscale three-dimensional (3D) scaffold using tricalcium phosphate nanoparticles (triCaPNPs) in a substrate of poly(acrylic acid) (PAA) polymer for controlled release of exosomes in bone t…
View article: Synergistic effect of quercetin and cobalt ferrite-graphene oxide-based hyperthermia to inhibit expression of heat shock proteins and induce apoptosis in breast cancer cells
Synergistic effect of quercetin and cobalt ferrite-graphene oxide-based hyperthermia to inhibit expression of heat shock proteins and induce apoptosis in breast cancer cells Open
Background: Combinatorial medicine includes promising therapeutic methods for diseases such as cancer, whereby various biochemical and physical agents are simultaneously used to remove tumors. For example, the effectiveness of hyperthermia…
View article: Surface Coating of Polyurethane Films with Gelatin, Aspirin and Heparin to Increase the Hemocompatibility of Artificial Vascular Grafts
Surface Coating of Polyurethane Films with Gelatin, Aspirin and Heparin to Increase the Hemocompatibility of Artificial Vascular Grafts Open
Purpose: A hemocompatible substrate can offer a wonderful facility for nitric oxide (NO) production by vascular endothelial cells in reaction to the inflammation following injuries. NO inhibits platelet aggregation this is especially criti…
View article: Repairing rat calvarial defects by adipose mesenchymal stem cells and novel freeze-dried three-dimensional nanofibrous scaffolds
Repairing rat calvarial defects by adipose mesenchymal stem cells and novel freeze-dried three-dimensional nanofibrous scaffolds Open
Introduction: Treatment of critical-sized bone defects is challenging. Tissue engineering as a state-of-the-art method has been concerned with treating these non-self-healing bone defects. Here, we studied the potentials of new three-dimen…
View article: Evaluation of <i>in vitro</i> fibroblast migration by electrospun triple-layered PU-CA/gelatin.PRGF/PU-CA scaffold using an AAVS1 targeted EGFP reporter cell line
Evaluation of <i>in vitro</i> fibroblast migration by electrospun triple-layered PU-CA/gelatin.PRGF/PU-CA scaffold using an AAVS1 targeted EGFP reporter cell line Open
Introduction: Migration of fibroblast cells in wound areas is a critical aspect of the wound healing process. Employment of enhanced green fluorescent protein (EGFP) labeled fibroblast cells facilitates real-time monitoring and functional …
View article: PANC-1 cancer stem-like cell death with silybin encapsulated in polymersomes and deregulation of stemness-related miRNAs and their potential targets.
PANC-1 cancer stem-like cell death with silybin encapsulated in polymersomes and deregulation of stemness-related miRNAs and their potential targets. Open
We suggest that silybin encapsulated in polymersomes (SPNs) may be useful as a complementary agent for destroying both pancreatic cancer cells and pancreatic CSCs along with chemotherapeutic agents.
View article: Optimization of Topography and Surface Properties of Polyacrylonitrile-Based Electrospun Scaffolds via Nonoclay Concentrations and its Effect on Osteogenic Differentiation of Human Mesenchymal Stem Cells.
Optimization of Topography and Surface Properties of Polyacrylonitrile-Based Electrospun Scaffolds via Nonoclay Concentrations and its Effect on Osteogenic Differentiation of Human Mesenchymal Stem Cells. Open
Nowadays, mesenchymal stem cells (MSCs) are the most widely used cell sources for bone regenerative medicine. Electrospun polyacrylonitrile (PAN)-based scaffolds play an important role in bone tissue engineering due to their good mechanica…
View article: Ursolic Acid Improve Skeletal Muscle Hypertrophy by Increasing of PAX7, Myod and Myogenin Expression and Satellite Cells Proliferation in Native Broiler Chickens
Ursolic Acid Improve Skeletal Muscle Hypertrophy by Increasing of PAX7, Myod and Myogenin Expression and Satellite Cells Proliferation in Native Broiler Chickens Open
Ursolic Acid Improve Skeletal Muscle Hypertrophy by Increasing of PAX7, Myod and Myogenin Expression and Satellite Cells Proliferation in Native Broiler Chickens
View article: Apoptosis induction and proliferation inhibition by silibinin encapsulated in nanoparticles in MIA PaCa-2 cancer cells and deregulation of some miRNAs.
Apoptosis induction and proliferation inhibition by silibinin encapsulated in nanoparticles in MIA PaCa-2 cancer cells and deregulation of some miRNAs. Open
Our results suggested that SPNs induced apoptosis and inhibited migration and proliferation in pancreatic cells and cancer stem cells through suppression of some onco-miRs and induction of some tumor suppressive miRs, as well as their targ…
View article: Freeze-dried multiscale porous nanofibrous three dimensional scaffolds for bone regenerations
Freeze-dried multiscale porous nanofibrous three dimensional scaffolds for bone regenerations Open
Introduction: Simulating hydrophobic-hydrophilic composite face with hierarchical porous and fibrous architectures of bone extracellular matrix (ECM) is a key aspect in bone tissue engineering. This study focused on the fabrication of new …
View article: Appropriate Scaffold Selection for CNS Tissue Engineering.
Appropriate Scaffold Selection for CNS Tissue Engineering. Open
Cellular transplantation, due to the low regenerative capacity of the Central Nervous System (CNS), is one of the promising strategies in the treatment of neurodegenerative diseases. The design and application of scaffolds mimicking the CN…
View article: The Comparison between the Osteogenic Differentiation Potential of Clay-Polyacrylonitrile Nanocomposite Scaffold and Graphene-Polyacrylonitrile Scaffold in Human Mesenchymal Stem Cells
The Comparison between the Osteogenic Differentiation Potential of Clay-Polyacrylonitrile Nanocomposite Scaffold and Graphene-Polyacrylonitrile Scaffold in Human Mesenchymal Stem Cells Open
Nowadays, bone repair by means of stem cells potential is considered as a new approach in regenerative medicine. Adipose-derived mesenchymal stem cells (AD-MSCs) have been investigated as a plentiful cell source with the ability of osteoge…
View article: The osmolyte type affects cartilage associated pathologic marker expression during in vitro mesenchymal stem cell chondrogenesis under hypertonic conditions
The osmolyte type affects cartilage associated pathologic marker expression during in vitro mesenchymal stem cell chondrogenesis under hypertonic conditions Open
Stem cells' fate during in vitro differentiation is influenced by biophysicochemical cues. Osmotic stress has proved to enhance chondrocyte marker expression, however its potent negative impacts had never been surveyed. We questioned wheth…
View article: <i>In vitro</i> fibroblast migration by sustained release of PDGF-BB loaded in chitosan nanoparticles incorporated in electrospun nanofibers for wound dressing applications
<i>In vitro</i> fibroblast migration by sustained release of PDGF-BB loaded in chitosan nanoparticles incorporated in electrospun nanofibers for wound dressing applications Open
Migration of fibroblasts into wound area is a critical phenomenon in wound healing process. We used an appropriate system to fabricate an electrospun bioactive scaffold with controlled release of PDGF-BB in order to induce migration of pri…
View article: More Precise Mapping of Gliobalstoma Based on a Nanoprobe-Decorated Drug Molecule
More Precise Mapping of Gliobalstoma Based on a Nanoprobe-Decorated Drug Molecule Open
Modern neuroscience is on the verge of exploring new frontiers within various subdisciplines.The question of how our brain with over hundred billion neurons puts together cognition, emotion and behavior has always been captivating.As such,…