Sinclair Emans
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View article: Combined Downregulation of Insulin and Mitochondrial Signaling Leads to Synergistic Life- and Healthspan Extension in Caenorhabditis Elegans
Combined Downregulation of Insulin and Mitochondrial Signaling Leads to Synergistic Life- and Healthspan Extension in Caenorhabditis Elegans Open
The Caenorhabditis elegans insulin/IGF-1 signaling (IIS) pathway functions as both a rheostat for nutrient levels and as an evolutionarily conserved mechanism likely to shed light on its functions and regulation in higher organisms. Early …
View article: Ribosomal RNA Synthesis is a Lethal Vulnerability During Reductive Stress In <i>C</i> . <i>elegans</i>
Ribosomal RNA Synthesis is a Lethal Vulnerability During Reductive Stress In <i>C</i> . <i>elegans</i> Open
Reductive stress has remained underappreciated as a significant disrupter of redox homeostasis. Recent studies have begun to link the accumulation of NADH and NADPH to the development and progression of metabolic diseases such as cancer, c…
View article: Reductive death is averted by an ancient metabolic switch
Reductive death is averted by an ancient metabolic switch Open
SUMMARY Biguanides, including metformin, the world’s most prescribed oral hypoglycemic, extend health-span and lifespan in vertebrates and invertebrates. Given the widespread use and apparent safety of metformin, it is assumed that its eff…
View article: GRD-1/PTR-11, the <i>C. elegans</i> hedgehog/patched-like morphogen-receptor pair, modulates developmental rate
GRD-1/PTR-11, the <i>C. elegans</i> hedgehog/patched-like morphogen-receptor pair, modulates developmental rate Open
Both hedgehog (Hh) and target of rapamycin complex 2 (TORC2) are central, evolutionarily conserved signaling pathways that regulate development and metabolism. In C. elegans, loss of the essential TORC2 component RICTOR (rict-1) causes del…
View article: Ether lipid biosynthesis promotes lifespan extension and enables diverse pro-longevity paradigms in Caenorhabditis elegans
Ether lipid biosynthesis promotes lifespan extension and enables diverse pro-longevity paradigms in Caenorhabditis elegans Open
Biguanides, including the world’s most prescribed drug for type 2 diabetes, metformin, not only lower blood sugar, but also promote longevity in preclinical models. Epidemiologic studies in humans parallel these findings, indicating favora…
View article: Author response: Ether lipid biosynthesis promotes lifespan extension and enables diverse pro-longevity paradigms in Caenorhabditis elegans
Author response: Ether lipid biosynthesis promotes lifespan extension and enables diverse pro-longevity paradigms in Caenorhabditis elegans Open
Full text Figures and data Side by side Abstract Editor's evaluation eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abs…
View article: Target of Rapamycin Complex 2 modulates development through Hedgehog/Patched signaling in<i>C. elegans</i>
Target of Rapamycin Complex 2 modulates development through Hedgehog/Patched signaling in<i>C. elegans</i> Open
Both Hedgehog (Hh) signaling and target of rapamycin complex 2 (TORC2) are central, evolutionarily conserved pathways that regulate development and metabolism. In C. elegans , loss of essential TORC2 component RICTOR ( rict-1 ) causes dela…
View article: Riboflavin depletion promotes longevity and metabolic hormesis in <i>Caenorhabditis elegans</i>
Riboflavin depletion promotes longevity and metabolic hormesis in <i>Caenorhabditis elegans</i> Open
Riboflavin is an essential cofactor in many enzymatic processes and in the production of flavin adenine dinucleotide (FAD). Here, we report that the partial depletion of riboflavin through knockdown of the C. elegans riboflavin transporter…
View article: Riboflavin Depletion Promotes Longevity and Metabolic Hormesis in <i>Caenorhabditis elegans</i>
Riboflavin Depletion Promotes Longevity and Metabolic Hormesis in <i>Caenorhabditis elegans</i> Open
Summary Riboflavin is an essential cofactor in many enzymatic processes and in the production of flavin adenine dinucleotide (FAD). Here we report that the partial depletion of riboflavin through knockdown of the C. elegans riboflavin tran…
View article: Ether Lipid Biosynthesis Promotes Lifespan Extension and Enables Diverse Prolongevity Paradigms in <i>Caenorhabditis elegans</i>
Ether Lipid Biosynthesis Promotes Lifespan Extension and Enables Diverse Prolongevity Paradigms in <i>Caenorhabditis elegans</i> Open
Biguanides, including the world’s most commonly prescribed drug for type 2 diabetes, metformin, not only lower blood sugar, but also promote longevity in preclinical models. Epidemiologic studies in humans parallel these findings, indicati…