Explanipedia

Increasing physical activity and reducing sedentary behaviour in patients diagnosed with non-affective psychosis: a cross-sectional UK study identifying cognitions to target in treatment Open

Rowan Diamond, Bao Sheng Loe, Felicity Waite, Felicity Hudson, Sinéad Lambe , et al. · 2025

Summary: Background: Better interventions are needed to help individuals diagnosed with psychosis to be more physically active and less sedentary. Cognitions are likely to be crucial in blocking and initiating movement. Our aim was to iden…

The Oxford Paranoia Defence Behaviours Questionnaire (O-PDQ): assessing paranoia-related safety-seeking behaviours Open

Sinéad Lambe, Sophie Mulhall, Jessica C. Bird, Kira Williams, Joanna Mitchell , et al. · 2025

Background: Defence behaviours – actions carried out to reduce perceived threat – are an important maintenance factor for persecutory delusions. Avoidance of feared situations and subtle in-situation behaviours reduce opportunities for new…

Real-world waitlist randomised controlled trial of gameChange VR to treat severe agoraphobic avoidance in patients with psychosis: a study protocol Open

Daniel Freeman, Julia Jones, Eloise Prouten, John Sainsbury, Anthony P. Morrison , et al. · 2025

Introduction Many people with psychosis find the world very frightening. It can be difficult for them to do everyday things—for example, walking down a busy street, travelling on a bus or going to the shops. Sometimes, the fears are so gre…

Engagement and attrition in digital mental health: current challenges and potential solutions Open

Katharine Smith, Thomas Ward, Sinéad Lambe, Edoardo G. Ostinelli, Charlotte Blease , et al. · 2025

Systematic review of risk factors for violence in psychosis: 10-year update Open

Tyra Lagerberg, Sinéad Lambe, Anabelle Paulino, Rongqin Yu, Seena Fazel · 2025

Background Understanding risk factors for violence in people with psychosis can inform risk management and violence prevention. However, much of the evidence comes from cross-sectional studies, and previous reviews require updating. Aims T…

Are people noticing excessive mistrust in others and how do they understand it? A survey of a UK representative adult population Open

Ghizlane Slaoui, Helen Beckwith, Sinéad Lambe, Thomas Kabir, Glory Sokunle , et al. · 2025

Background If excessive mistrust – for example, holding conspiracy beliefs or experiencing paranoia – is widespread then people should notice it in others. We aimed to assess the degree to which the general population had observed excessiv…

Exploring stigma, shame, and safety behaviours in social anxiety and paranoia amongst people diagnosed with schizophrenia Open

Warut Aunjitsakul, Kreuwan Jongbowonwiwat, Sinéad Lambe, Daniel Freeman, Hamish J. McLeod , et al. · 2024

Background: Social anxiety and paranoia are connected by a shared suspicion framework. Based on cognitive-behavioural approaches, there is evidence for treating social anxiety and psychosis. However, mechanisms underlying the relationship …

A randomized controlled experiment testing the use of virtual reality to trigger cigarette craving in people who smoke Open

Aitor Rovira, Sinéad Lambe, Helen Beckwith, Memoona Ahmed, Felicity Hudson , et al. · 2024

Digital Mental Health for Schizophrenia and Other Severe Mental Illnesses: An International Consensus on Current Challenges and Potential Solutions Open

Katharine Smith, Amy Hardy, Anastasia Vinnikova, Charlotte Blease, Lea Milligan , et al. · 2024

Background Digital approaches may be helpful in augmenting care to address unmet mental health needs, particularly for schizophrenia and severe mental illness (SMI). Objective An international multidisciplinary group was convened to reach …

Digital Mental Health for Schizophrenia and Other Severe Mental Illnesses: An International Consensus on Current Challenges and Potential Solutions (Preprint) Open

Katharine Smith, Amy Hardy, Anastasia Vinnikova, Charlotte Blease, Lea Milligan , et al. · 2024

BACKGROUND Digital approaches may be helpful in augmenting care to address unmet mental health needs, particularly for schizophrenia and severe mental illness (SMI). OBJECTIVE An international multidisciplinary group was convened to rea…

Psychological framework to understand interpersonal violence by forensic patients with psychosis Open

Sinéad Lambe, Kate Cooper, Seena Fazel, Daniel Freeman · 2023

Background Forensic patients with psychosis often engage in violent behaviour. There has been significant progress in understanding risk factors for violence, but identification of causal mechanisms of violence is limited. Aims To develop …

The role of social media platforms for diversified farm businesses in Scotland Open

Leanne Townsend, Sinéad Lambe, Sharon Flanigan, Christina Noble, Rachel Creaney , et al. · 2023

This policy brief is concerned with the role of social media platforms for diversified farm businesses in Scotland. First, it outlines the benefits of diversification into digital platforms for farm businesses, and highlights good practice…

Automated virtual reality cognitive therapy versus virtual reality mental relaxation therapy for the treatment of persistent persecutory delusions in patients with psychosis (THRIVE): a parallel-group, single-blind, randomised controlled trial in England with mediation analyses Open

Daniel Freeman, Rachel Lister, Felicity Waite, Ushma Galal, Ly‐Mee Yu , et al. · 2023

Medical Research Council Developmental Pathway Funding Scheme and National Institute for Health and Care Research Oxford Health Biomedical Research Centre.

Virtual reality (VR) therapy for patients with psychosis: satisfaction and side effects. Open

Daniel Freeman, Laina Rosebrock, Felicity Waite, Bao Sheng Loe, Thomas Kabir , et al. · 2023

Patients with psychosis were generally very positive towards the VR therapy, valued having the opportunity to try the technology, and experienced few adverse effects. Side effects did not significantly impact VR therapy. Patient experience…

A Safe Place to Learn: Peer Research Qualitative Investigation of gameChange Virtual Reality Therapy Open

Jessica Bond, Alex Kenny, Vanessa Pinfold, Lisa Couperthwaite, Thomas Kabir , et al. · 2023

Background Automated virtual reality (VR) therapy has the potential to substantially increase access to evidence-based psychological treatments. The results of a multicenter randomized controlled trial showed that gameChange VR cognitive t…

Treating trauma-driven OCD with narrative exposure therapy alongside cognitive behavioural therapy Open

Jac Airdrie, Sinéad Lambe, Kate Cooper · 2023

When post-traumatic stress disorder (PTSD) co-occurs with obsessive compulsive disorder (OCD), symptoms of the former can interfere with evidence-based treatment of the latter. As a result, exposure-based treatments are recommended for bot…

Estimating the Economic Value of Automated Virtual Reality Cognitive Therapy for Treating Agoraphobic Avoidance in Patients With Psychosis: Findings From the gameChange Randomized Controlled Clinical Trial Open

James Altunkaya, Michael P. Craven, Sinéad Lambe, Ariane Beckley, Laina Rosebrock , et al. · 2022

Background An automated virtual reality cognitive therapy (gameChange) has demonstrated its effectiveness to treat agoraphobia in patients with psychosis, especially for high or severe anxious avoidance. Its economic value to the health ca…

Agoraphobic avoidance in patients with psychosis: Severity and response to automated VR therapy in a secondary analysis of a randomised controlled clinical trial Open

Daniel Freeman, Sinéad Lambe, Ushma Galal, Ly‐Mee Yu, Thomas Kabir , et al. · 2022

Patients with psychosis with severe agoraphobic avoidance, such as being unable to leave the home, have high clinical need. Automated VR therapy can deliver clinical improvement in agoraphobia for these patients, leading to a number of wid…

Virtual reality (VR) therapy for patients with psychosis: satisfaction and side effects Open

Daniel Freeman, Laina Rosebrock, Felicity Waite, Bao Sheng Loe, Thomas Kabir , et al. · 2022

Background Automated virtual reality therapies are being developed to increase access to psychological interventions. We assessed the experience with one such therapy of patients diagnosed with psychosis, including satisfaction, side effec…

Automated virtual reality therapy to treat agoraphobic avoidance and distress in patients with psychosis (gameChange): a multicentre, parallel-group, single-blind, randomised, controlled trial in England with mediation and moderation analyses Open

Daniel Freeman, Sinéad Lambe, Thomas Kabir, Ariane Petit, Laina Rosebrock , et al. · 2022

National Institute of Health Research Invention for Innovation programme, National Institute of Health Research Oxford Health Biomedical Research Centre.

Understanding agoraphobic avoidance: the development of the Oxford Cognitions and Defences Questionnaire (O-CDQ) Open

Laina Rosebrock, Sinéad Lambe, Sophie Mulhall, Ariane Petit, Bao Sheng Loe , et al. · 2022

Background: Many patients with mental health disorders become increasingly isolated at home due to anxiety about going outside. A cognitive perspective on this difficulty is that threat cognitions lead to the safety-seeking behavioural res…

“ <i>It seems impossible that it’s been made so quickly</i> ”: a qualitative investigation of concerns about the speed of COVID-19 vaccine development and how these may be overcome Open

Poppy Brown, Felicity Waite, Michael Larkin, Sinéad Lambe, Helen McShane , et al. · 2022

The speed of COVID-19 vaccine development has been identified as a central concern contributing to hesitancy in acceptance. We conducted qualitative interviews to gain a greater understanding into these concerns and to identify what might …

Automated Virtual Reality Cognitive Therapy (gameChange) in Inpatient Psychiatric Wards: Qualitative Study of Staff and Patient Views Using an Implementation Framework Open

Poppy Brown, Felicity Waite, Sinéad Lambe, Julia Jones, Lucy Jenner , et al. · 2022

Background Automated virtual reality (VR) therapy could allow a greater number of patients to receive evidence-based psychological therapy. The aim of the gameChange VR therapy is to help patients overcome anxious avoidance of everyday soc…

The Oxford Agoraphobic Avoidance Scale Open

Sinéad Lambe, Jessica C. Bird, Bao Sheng Loe, Laina Rosebrock, Thomas Kabir , et al. · 2021

Background Agoraphobic avoidance of everyday situations is a common feature in many mental health disorders. Avoidance can be due to a variety of fears, including concerns about negative social evaluation, panicking, and harm from others. …

Automated Virtual Reality Cognitive Therapy for People With Psychosis: Protocol for a Qualitative Investigation Using Peer Research Methods Open

Jessica Bond, Dan Robotham, Alex Kenny, Vanessa Pinfold, Thomas Kabir , et al. · 2021

Background Many people with psychosis experience difficulties in everyday social situations. Anxiety can make life challenging, leading to withdrawal. Cognitive therapy, using active in vivo learning, enables people to overcome fears. Thes…

Comparison of a theoretically driven cognitive therapy (the Feeling Safe Programme) with befriending for the treatment of persistent persecutory delusions: a parallel, single-blind, randomised controlled trial Open

Daniel Freeman, Richard Emsley, Rowan Diamond, Nicola Collett, Emily Bold , et al. · 2021

Automated Virtual Reality Cognitive Therapy for People With Psychosis: Protocol for a Qualitative Investigation Using Peer Research Methods (Preprint) Open

Jessica Bond, Dan Robotham, Alex Kenny, Vanessa Pinfold, Thomas Kabir , et al. · 2021

BACKGROUND Many people with psychosis experience difficulties in everyday social situations. Anxiety can make life challenging, leading to withdrawal. Cognitive therapy, using active in vivo learning, enables people to overcome fears. The…

Injection fears and COVID-19 vaccine hesitancy Open

Daniel Freeman, Sinéad Lambe, Ly‐Mee Yu, Jason Freeman, Andrew Chadwick , et al. · 2021

Background When vaccination depends on injection, it is plausible that the blood-injection-injury cluster of fears may contribute to hesitancy. Our primary aim was to estimate in the UK adult population the proportion of COVID-19 vaccine h…

Effects of different types of written vaccination information on COVID-19 vaccine hesitancy in the UK (OCEANS-III): a single-blind, parallel-group, randomised controlled trial Open

Daniel Freeman, Bao Sheng Loe, Ly‐Mee Yu, Jason Freeman, Andrew Chadwick , et al. · 2021

COVID-19 vaccines, hesitancy and mental health Open

Katharine Smith, Sinéad Lambe, Daniel Freeman, Andrea Cipriani · 2021

In this study, we compared the accuracy of the rate of myocardial glucose use (rMGU) measured using PET and 1-¹¹C-glucose with the rate measured using PET and the more conventional tracer ¹⁸F-FDG. Methods: PET …

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