Vijay K. Singh
YOU?
Author Swipe
View article: Serum and CSF cytokine profile in patients with facial palsy (Bell’s palsy): a pilot study
Serum and CSF cytokine profile in patients with facial palsy (Bell’s palsy): a pilot study Open
Background and purpose Facial nerve palsy is the most common cranial nerve disorder, and over 60% are idiopathic (Bell’s palsy, BP). An inflammatory process is discussed as a causative factor. The aim of this study was to search for change…
View article: Cutting-edge animal models for radiation combined injury drug development
Cutting-edge animal models for radiation combined injury drug development Open
Several animal models are currently being developed to study RCI and drugs for its treatment. These animal models are important for regulatory approval of RCI drugs designed to enhance survival outcomes.
View article: Development of PLX-R18, a promising and novel countermeasure for radiation-associated injuries
Development of PLX-R18, a promising and novel countermeasure for radiation-associated injuries Open
PLX-R18 is a novel cell-based product of ex vivo expanded adherent human-placenta-derived stromal cells. After intramuscular administration, these living cells are capable of secreting various cytokines that produce a therapeutic benefit. …
View article: Serum Metabolomic Signatures in Nonhuman Primates Treated with a Countermeasure and Exposed to Partial- or Total-Body Radiation
Serum Metabolomic Signatures in Nonhuman Primates Treated with a Countermeasure and Exposed to Partial- or Total-Body Radiation Open
Background: Irradiation-induced injury is a common fallout of radiological/nuclear accidents or therapeutic exposures to high doses of radiation at high dose rates. Currently, there are no prophylactic drugs available to mitigate radiation…
View article: New opportunities and current challenges using animal models for the discovery of novel countermeasures for acute radiation syndrome
New opportunities and current challenges using animal models for the discovery of novel countermeasures for acute radiation syndrome Open
Relative to large animal models, the rhesus macaque model is currently the most used and best characterized for translational relevance. Other large animal models (e.g. minipig) are currently used as well to evaluate other specific types o…
View article: Comparison of sensitivity of rhesus and cynomolgus macaque for acute radiation effects.
Comparison of sensitivity of rhesus and cynomolgus macaque for acute radiation effects. Open
Radiation medical countermeasure development under the United States Food and Drug Administration Animal Rule needs validated large animal models of acute radiation syndrome. Such a well-established large animal model is the rhesus nonhuma…
View article: Multi-faceted approach for identifying biomarkers for radiation injury and regulatory approval of radiation medical countermeasures
Multi-faceted approach for identifying biomarkers for radiation injury and regulatory approval of radiation medical countermeasures Open
Acute radiation syndrome (ARS) is caused by high doses of ionizing radiation (> 2 Gy). ARS is broken down into 3 sub-syndromes: exposure to 2–6 Gy results in hematopoietic ARS (H-ARS), exposure to 6–10 Gy results in gastrointestinal ARS (G…
View article: Unravelling the impacts of elevated CO2 and elevated temperature on Spodoptera exigua in chickpea - Indian climate change context
Unravelling the impacts of elevated CO2 and elevated temperature on Spodoptera exigua in chickpea - Indian climate change context Open
Climate change is a worldwide concern with a peril to the long-term viability of agriculture. Elevated temperature (eTemp.) and elevated CO2 (eCO2) are the two facets of climate change with a substantial effect on crop production and prote…
View article: Cross-species conserved miRNA as biomarker of radiation injury over a wide dose range using nonhuman primate model
Cross-species conserved miRNA as biomarker of radiation injury over a wide dose range using nonhuman primate model Open
Multiple accidents in nuclear power plants and the growing concerns about the misuse of radiation exposure in warfare have called for the rapid determination of absorbed radiation doses (RDs). The latest findings about circulating microRNA…
View article: P55 The boggy uveitis
P55 The boggy uveitis Open
Introduction Blau syndrome is a rare autosomal dominant autoinflammatory disease that affects young children. Typically, it causes widespread granulomatous inflammation, causing uveitis, arthritis, and dermatitis. The triad may be characte…
View article: Radiation Signature in Plasma Metabolome of Total-Body Irradiated Nonhuman Primates and Clinical Patients
Radiation Signature in Plasma Metabolome of Total-Body Irradiated Nonhuman Primates and Clinical Patients Open
In the last decade, geopolitical instability across the globe has increased the risk of a large-scale radiological event, when radiation biomarkers would be needed for an effective triage of an irradiated population. Ionizing radiation eli…
View article: BIO 300: A Prophylactic Radiation Countermeasure for Acute Radiation Syndrome
BIO 300: A Prophylactic Radiation Countermeasure for Acute Radiation Syndrome Open
Introduction Exposure to high doses of ionizing radiation can result in hematopoietic acute radiation syndrome. Currently, there is no radiation medical countermeasure approved by the U.S. FDA which can be used before radiation exposure to…
View article: BIO 300 Attenuates Whole Blood Transcriptome Changes in Mice Exposed to Total-Body Radiation
BIO 300 Attenuates Whole Blood Transcriptome Changes in Mice Exposed to Total-Body Radiation Open
Development of radiation medical countermeasures under the U.S. Food and Drug Administration Animal Rule requires the capability to translate an effective animal-to-human drug dose. One method of human dose translation is using a biomarker…
View article: New pharmaceutical-based strategies that foster the development and promulgation of globally effective medical countermeasures for radiation exposure injuries
New pharmaceutical-based strategies that foster the development and promulgation of globally effective medical countermeasures for radiation exposure injuries Open
KEYWORDS: countermeasureFood and Drug Administrationionizing radiationmicenonhuman primatespolypharmacy, radiation injury
View article: An Overview of Radiation Countermeasure Development in Radiation Research from 1954 to 2024
An Overview of Radiation Countermeasure Development in Radiation Research from 1954 to 2024 Open
Preparation for medical responses to major radiation accidents, further driven by increases in the threat of nuclear warfare, has led to a pressing need to understand the underlying mechanisms of radiation injury (RI) alone or in combinati…
View article: Pathology of acute sub-lethal or near-lethal irradiation of nonhuman primates prophylaxed with the nutraceutical, gamma tocotrienol
Pathology of acute sub-lethal or near-lethal irradiation of nonhuman primates prophylaxed with the nutraceutical, gamma tocotrienol Open
Exposure to high, marginally lethal doses or higher of ionizing radiation, either intentional or accidental, results in injury to various organs. Currently, there is only a limited number of safe and effective radiation countermeasures app…
View article: Pharmacokinetic and Metabolomic Studies with a Promising Radiation Countermeasure, BBT-059 (PEGylated interleukin-11), in Rhesus Nonhuman Primates
Pharmacokinetic and Metabolomic Studies with a Promising Radiation Countermeasure, BBT-059 (PEGylated interleukin-11), in Rhesus Nonhuman Primates Open
BBT-059, a long-acting PEGylated interleukin-11 (IL-11) analog that is believed to have hematopoietic promoting and anti-apoptotic properties, is being developed as a potential radiation medical countermeasure (MCM) for hematopoietic acute…
View article: Proteomic Analysis of Plasma at the Preterminal Stage of Rhesus Nonhuman Primates Exposed to a Lethal Total-Body Dose of Gamma-Radiation
Proteomic Analysis of Plasma at the Preterminal Stage of Rhesus Nonhuman Primates Exposed to a Lethal Total-Body Dose of Gamma-Radiation Open
The identification and validation of radiation biomarkers is critical for assessing the radiation dose received in exposed individuals and for developing radiation medical countermeasures that can be used to treat acute radiation syndrome …
View article: Validating a Four-gene Set for H-ARS Severity Prediction in Peripheral Blood Samples of Irradiated Rhesus Macaques
Validating a Four-gene Set for H-ARS Severity Prediction in Peripheral Blood Samples of Irradiated Rhesus Macaques Open
Increased radiological and nuclear threats require preparedness. Our earlier work identified a set of four genes (DDB2, FDXR, POU2AF1 and WNT3), which predicts severity of the hematological acute radiation syndrome (H-ARS) within the first…
View article: PUM1 and PGK1 are Favorable Housekeeping Genes over Established Biodosimetry-related Housekeeping Genes such as HPRT1, ITFG1, DPM1, MRPS5, 18S rRNA and Others after Radiation Exposure
PUM1 and PGK1 are Favorable Housekeeping Genes over Established Biodosimetry-related Housekeeping Genes such as HPRT1, ITFG1, DPM1, MRPS5, 18S rRNA and Others after Radiation Exposure Open
In gene expression (GE) studies, housekeeping genes (HKGs) are required for normalization purposes. In large-scale inter-laboratory comparison studies, significant differences in dose estimates are reported and divergent HKGs are employed …
View article: Histopathological studies of nonhuman primates exposed to supralethal doses of total- or partial-body radiation: influence of a medical countermeasure, gamma-tocotrienol
Histopathological studies of nonhuman primates exposed to supralethal doses of total- or partial-body radiation: influence of a medical countermeasure, gamma-tocotrienol Open
Despite remarkable scientific progress over the past six decades within the medical arts and in radiobiology in general, limited radiation medical countermeasures (MCMs) have been approved by the United States Food and Drug Administration …
View article: Serum microRNA profile of rhesus macaques following ionizing radiation exposure and treatment with a medical countermeasure, Ex-Rad
Serum microRNA profile of rhesus macaques following ionizing radiation exposure and treatment with a medical countermeasure, Ex-Rad Open
Exposure to ionizing radiation (IR) presents a formidable clinical challenge. Total-body or significant partial-body exposure at a high dose and dose rate leads to acute radiation syndrome (ARS), the complex pathologic effects that arise f…
View article: Metabolomic Changes in Plasma of Preterminal Stage of Rhesus Nonhuman Primates Exposed to Lethal Dose of Radiation
Metabolomic Changes in Plasma of Preterminal Stage of Rhesus Nonhuman Primates Exposed to Lethal Dose of Radiation Open
Ionizing radiation exposure is known to induce molecular and cellular injury, inflicting a cascade of potentially catastrophic events leading to tissue and organ damage. Metabolomic analysis allows for the identification and quantification…
View article: The potential value of 5-androstenediol in countering acute radiation syndrome
The potential value of 5-androstenediol in countering acute radiation syndrome Open
Moderate-to-high doses of ionizing irradiation can lead to potentially life-threatening morbidities and increase mortality risk. In preclinical testing, 5-androstenediol has been shown to be effective in protecting against hematopoietic ac…