Sinian Wang
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View article: Piezo1 regulates autophagy in HT22 hippocampal neurons through the Ca2+/Calpain and Calcineurin/TFEB signaling pathways
Piezo1 regulates autophagy in HT22 hippocampal neurons through the Ca2+/Calpain and Calcineurin/TFEB signaling pathways Open
Objective To investigate the functional and molecular mechanisms by which Piezo1regulates HT-22 hippocampal neuronal autophagy, and to explore whether Piezo1 regulates hippocampal neuronal autophagy via the Ca 2+ /Calpain, CaMKKβ, or Calci…
View article: Nuclear receptor <scp>Rev‐erbα</scp> alleviates intervertebral disc degeneration by recruiting <scp>NCoR</scp>–<scp>HDAC3</scp> co‐repressor and inhibiting <scp>NLRP3</scp> inflammasome
Nuclear receptor <span>Rev‐erbα</span> alleviates intervertebral disc degeneration by recruiting <span>NCoR</span>–<span>HDAC3</span> co‐repressor and inhibiting <span>NLRP3</span> inflammasome Open
Intervertebral discs (IVDs) are rhythmic tissues that experience daily low‐load recovery. Notably, aging and abnormal mechanical stress predispose IVDs to degeneration due to dysrhythmia‐induced disordered metabolism. Meanwhile, Rev‐erbα a…
View article: Neutrophil‑to‑lymphocyte ratio reflects lung injury in thoracic radiotherapy and immune checkpoint inhibitors combination therapy with different sequences
Neutrophil‑to‑lymphocyte ratio reflects lung injury in thoracic radiotherapy and immune checkpoint inhibitors combination therapy with different sequences Open
The combination of thoracic radiotherapy and immune checkpoint inhibitors (ICIs) has emerged as a novel treatment approach for malignant tumors. However, it is important to consider the potential exacerbation of lung injury associated with…
View article: Not All Osteophytes Are Located on the Right Side of the Vertebrae in Diffuse Idiopathic Skeletal Hyperostosis: A Quantitative Analysis in Relation to the Position of Aorta
Not All Osteophytes Are Located on the Right Side of the Vertebrae in Diffuse Idiopathic Skeletal Hyperostosis: A Quantitative Analysis in Relation to the Position of Aorta Open
Objective Diffuse idiopathic skeletal hyperostosis (DISH) is characterized by osteophytes in the anterior vertebrae, and the presence of aorta may have an impact on their formation. However, the anatomical positional relationship between t…
View article: miR-139-5p Regulates <i>PIEZO1</i> Expression to Modulate Radiation-induced Injury in Type II Alveolar Epithelial Cells: A Hypothesis
miR-139-5p Regulates <i>PIEZO1</i> Expression to Modulate Radiation-induced Injury in Type II Alveolar Epithelial Cells: A Hypothesis Open
Radiation-induced pulmonary injury (RIPI) is a common adverse reaction when ionizing radiation acts on the lung. Type II alveolar epithelial cells participate in the process of RIPI by regulating inflammation, epithelial-mesenchymal transi…
View article: CRX-527 induced differentiation of HSCs protecting the intestinal epithelium from radiation damage
CRX-527 induced differentiation of HSCs protecting the intestinal epithelium from radiation damage Open
Recently, Toll-like receptors (TLRs) have been extensively studied in radiation damage, but the inherent defects of high toxicity and low efficacy of most TLR ligands limit their further clinical transformation. CRX-527, as a TLR4 ligand, …
View article: The Protective Effects of Apigenin Against Radiation‐Induced Intestinal Injury
The Protective Effects of Apigenin Against Radiation‐Induced Intestinal Injury Open
Radiation-induced intestinal injury (RIII) restricts the therapeutic efficacy of radiotherapy in abdominal or pelvic malignancies. Also, intestinal injury is a major cause of death following exposure to high doses of radiation in nuclear a…
View article: CRX-527 induced differentiation of HSCs protecting the intestinal epithelium from radiation damage.
CRX-527 induced differentiation of HSCs protecting the intestinal epithelium from radiation damage. Open
Background: Recently, Toll-like receptors (TLRs) have been extensively studied in radiation damage. However, the inherent defects of high toxicity and low efficacy of most TLR ligands limit their further clinical transformation. CRX-527, a…
View article: The hydrogen storage nanomaterial MgH <sub>2</sub> improves irradiation-induced male fertility impairment by suppressing oxidative stress
The hydrogen storage nanomaterial MgH <sub>2</sub> improves irradiation-induced male fertility impairment by suppressing oxidative stress Open
Objective This study aimed to reveal the protective effect of hydrogen storage nanomaterial MgH 2 on radiation-induced male fertility impairment. Methods The characterization of MgH 2 were analyzed by scanning electron microscopy (SEM) and…
View article: Disulfiram Protects Against Radiation-Induced Intestinal Injury in Mice
Disulfiram Protects Against Radiation-Induced Intestinal Injury in Mice Open
Radiation-induced intestinal injury (RIII) occurs after high doses of radiation exposure. RIII restricts the therapeutic efficacy of radiotherapy in cancer and increases morbidity and mortality in nuclear disasters. Currently, there is no …
View article: The Hydrogen Storage Nanomaterial MgH2 Improves Irradiation-induced Male Fertility Impairment by Suppressing Oxidative Stress
The Hydrogen Storage Nanomaterial MgH2 Improves Irradiation-induced Male Fertility Impairment by Suppressing Oxidative Stress Open
ObjectiveThis study aimed to reveal the protective effect of hydrogen storage nanomaterial MgH 2 on radiation-induced male fertility impairment.MethodsThe characterization of MgH 2 were analyzed by scanning electron microscopy (SEM) and pa…
View article: Dopamine-derived nanoparticles for the protection of irradiation-induced intestinal injury by maintaining intestinal homeostasis
Dopamine-derived nanoparticles for the protection of irradiation-induced intestinal injury by maintaining intestinal homeostasis Open
PDA-NPs improved the intestinal epithelium and maintained the intestinal barrier function after irradiation, in which PDA-NPs prevented the depletion of Lgr5 + ISCs and suppressed apoptosis, pyroptosis and DNA damage.
View article: Dimethyl Sulfoxide Attenuates Radiation‐Induced Testicular Injury through Facilitating DNA Double‐Strand Break Repair
Dimethyl Sulfoxide Attenuates Radiation‐Induced Testicular Injury through Facilitating DNA Double‐Strand Break Repair Open
The testis is susceptible to ionizing radiation, and male infertility and sexual dysfunction are prevalent problems after whole‐body or local radiation exposure. Currently, there is no approved agent for the prevention or treatment of radi…
View article: Insufficient ablation promotes the metastasis of residual non-small cell lung cancer (NSCLC) cells via upregulating carboxypeptidase A4
Insufficient ablation promotes the metastasis of residual non-small cell lung cancer (NSCLC) cells via upregulating carboxypeptidase A4 Open
This study demonstrates that sublethal heat stimulus caused by insufficient ablation can promote EMT and enhance the metastatic capacity of NSCLC. CPA4 plays an important role in these biological processes. Inhibition of CPA4 might be of g…
View article: Exposure to Low-Dose Radiation Enhanced the Antitumor Effect of a Dendritic Cell Vaccine
Exposure to Low-Dose Radiation Enhanced the Antitumor Effect of a Dendritic Cell Vaccine Open
The unsatisfactory clinical efficacy of dendritic cell (DC)-based cancer vaccines prepared by conventional methods is partly due to their insufficient capacity for migration. Our previous study showed that exposure to low-dose radiation (L…
View article: Plk1 promotes the migration of human lung adenocarcinoma epithelial cells via STAT3 signaling
Plk1 promotes the migration of human lung adenocarcinoma epithelial cells via STAT3 signaling Open
Polo-like kinase (Plk)1 contributes to the development of human cancer via multiple mechanisms, such as promoting the migration of cancer cells. However, the mechanistic basis for the regulation of cell migration by Plk1 remains unknown. T…
View article: Radiation induces the generation of cancer stem cells: A novel mechanism for cancer radioresistance
Radiation induces the generation of cancer stem cells: A novel mechanism for cancer radioresistance Open
Radioresistance remains a major obstacle for the radiotherapy treatment of cancer. Previous studies have demonstrated that the radioresistance of cancer is due to the existence of intrinsic cancer stem cells (CSCs), which represent a small…