Shuai Fan
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View article: Heterogeneity of active mast cells, endothelial cells, and fibroblasts in hemophilic arthritis defined by synovial single-cell sequencing
Heterogeneity of active mast cells, endothelial cells, and fibroblasts in hemophilic arthritis defined by synovial single-cell sequencing Open
Recurrent synovial bleeding is the major cause of Hemophilic Arthritis (HA). Up to now, the transcriptomic profiles of bleeding syvonium in HA patient have largely remained unknown. Exploring the transcriptomic characteristics of synovium …
View article: The feedback mechanism between water culture and water security in the Yellow River Basin
The feedback mechanism between water culture and water security in the Yellow River Basin Open
In the context of escalating global water resource challenges, examining the response of water cultural changes to water security and their governance becomes imperative for sustainable water management. Water culture can be seen as a refl…
View article: Andrographolide suppresses chondrosarcoma cell migration and invasion by inhibiting the PI3K/Akt/mTOR signaling pathway and activating autophagy
Andrographolide suppresses chondrosarcoma cell migration and invasion by inhibiting the PI3K/Akt/mTOR signaling pathway and activating autophagy Open
Objective Chondrosarcoma, a malignant bone tumor, exhibits a high incidence rate. This study employed network pharmacology and cell-based experiments to explore the molecular mechanisms by which andrographolide (Andro) suppressed the migra…
View article: Sleep Bruxism Is a Significant Risk Factor for the Recurrence of Temporomandibular Disorder: A Single‐Center Retrospective Study
Sleep Bruxism Is a Significant Risk Factor for the Recurrence of Temporomandibular Disorder: A Single‐Center Retrospective Study Open
Background Oral behaviours are risk factors for temporomandibular disorder (TMD), but the associations between oral behaviours and TMD prognosis remain unclear. Objective To assess the effect of oral behaviours on TMD prognosis. Methods Th…
View article: Advances in regenerative rehabilitation in the rehabilitation of musculoskeletal injuries
Advances in regenerative rehabilitation in the rehabilitation of musculoskeletal injuries Open
In the rapidly advancing field of regenerative medicine, relying solely on cell transplantation alone may be insufficient for achieving functional recovery, and rehabilitation before and after transplantation is crucial. Regenerative rehab…
View article: Short term effects of a novel combined approach compared with physical therapy alone among older patients with temporomandibular degenerative joint disease: a prospective cohort study
Short term effects of a novel combined approach compared with physical therapy alone among older patients with temporomandibular degenerative joint disease: a prospective cohort study Open
Background There is a lack of consensus regarding the best treatment option, including physical exercise, available for temporomandibular degenerative joint disease (DJD) that affect the older patients. Herein, we aimed to study and compar…
View article: Platelet-rich plasma attenuates the severity of joint capsule fibrosis following post-traumatic joint contracture in rats
Platelet-rich plasma attenuates the severity of joint capsule fibrosis following post-traumatic joint contracture in rats Open
Background: Post-traumatic joint contracture (PTJC) mainly manifests as excessive inflammation leading to joint capsule fibrosis. Transforming growth factor (TGF)-β1, a key regulator of inflammation and fibrosis, can promote fibroblast act…
View article: Comparison of Injection and Home Physical Exercise with Physical Therapy in Elderly Patients with Temporomandibular Joint Degenerative Disease: A Prospective Cohort Study
Comparison of Injection and Home Physical Exercise with Physical Therapy in Elderly Patients with Temporomandibular Joint Degenerative Disease: A Prospective Cohort Study Open
Background There are few reports on the treatment of elderly patients with temporomandibular joint degenerative disease (DJD) and on the effects of physical exercise in DJD. Herein, we aimed to study and compare the efficacy of injection a…
View article: Prognostic factor analysis in patients with temporomandibular disorders after reversible treatment: study protocol for a prospective cohort study in China
Prognostic factor analysis in patients with temporomandibular disorders after reversible treatment: study protocol for a prospective cohort study in China Open
Introduction Temporomandibular disorders (TMDs) are complex multifactorial disorders. Reversible treatment has been suggested for the initial management of TMD; however, comparable therapeutic effects of different reversible intervention m…
View article: Effectiveness of exercise therapy versus occlusal splint therapy for the treatment of painful temporomandibular disorders: a systematic review and meta-analysis
Effectiveness of exercise therapy versus occlusal splint therapy for the treatment of painful temporomandibular disorders: a systematic review and meta-analysis Open
Given the limitations of the study, the small number of studies included in the sub-analysis for pain relief and the maximum mouth-opening range, and the small overall standardized mean difference for pain relief and mandibular movement ob…
View article: Macrophage migration inhibitory factor activates the inflammatory response in joint capsule fibroblasts following post-traumatic joint contracture
Macrophage migration inhibitory factor activates the inflammatory response in joint capsule fibroblasts following post-traumatic joint contracture Open
MIF/CD74 axis elicited JF inflammation and may provide new therapeutic targets for joint capsule fibrosis in PTJC.
View article: The Impact of Education and Physical Therapy on Oral Behaviour in Patients with Temporomandibular Disorder: A Preliminary Study
The Impact of Education and Physical Therapy on Oral Behaviour in Patients with Temporomandibular Disorder: A Preliminary Study Open
Patient education is important in the treatment of temporomandibular disorder (TMD), but little is known about its effect on oral behaviors. We aimed to determine the dominant oral behaviours in patients with TMD and assess the impact of e…
View article: Macrophage migration inhibitory factor regulates joint capsule fibrosis by promoting TGF-β1 production in fibroblasts
Macrophage migration inhibitory factor regulates joint capsule fibrosis by promoting TGF-β1 production in fibroblasts Open
Joint capsule fibrosis caused by excessive inflammation results in post-traumatic joint contracture (PTJC). Transforming growth factor (TGF)-β1 plays a key role in PTJC by regulating fibroblast functions, however, cytokine-induced TGF-β1 e…