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View article: Insights into Hepatic, Neuronal, and hERG Channel Safety of Plant-Derived Active Compounds
Insights into Hepatic, Neuronal, and hERG Channel Safety of Plant-Derived Active Compounds Open
Curcumin (CUR), atractylodin (ATD), α-mangostin (αMG), ethyl-p-methoxycinnamate (EPMC), ligustilide (LIG), and β-eudesmol (BEU) are commonly used in Thai traditional medicine formulations. This study evaluated the cytotoxic effects of thes…
View article: Vitexicarpin suppresses colorectal and non-small cell lung cancer via selective inhibition of Anoctamin 1
Vitexicarpin suppresses colorectal and non-small cell lung cancer via selective inhibition of Anoctamin 1 Open
Colorectal cancer (CRC) and non-small cell lung cancer (NSCLC) remain among the most challenging malignancies to treat due to therapy complexity, adverse events, and dose-limiting toxicities, which often result in treatment failure. NSCLC,…
View article: <scp>HDAC4</scp>/5 Inhibitor, <scp>LMK</scp>‐235 Improves Animal Voluntary Movement in <scp>MPTP</scp>‐Induced Parkinson's Disease Model
<span>HDAC4</span>/5 Inhibitor, <span>LMK</span>‐235 Improves Animal Voluntary Movement in <span>MPTP</span>‐Induced Parkinson's Disease Model Open
Oxidation of dopamine can cause various side effects, which ultimately leads to cell death and contributes to Parkinson's disease (PD). To counteract dopamine oxidation, newly synthesized dopamine is quickly transported into vesicles via v…
View article: Hepatoprotective Lignan Glycosides from the Leaves and Stems of <i>Symplocos cochinchinensis</i> (Lour.) S. Moore
Hepatoprotective Lignan Glycosides from the Leaves and Stems of <i>Symplocos cochinchinensis</i> (Lour.) S. Moore Open
This study investigates Symplocos cochinchinensis (Lour.) S. Moore leaves and stems, commonly known as Symplocos, a plant indigenous to Asia renowned for its traditional use in holistic medicine. A comprehensive phytochemical analysis of S…
View article: Discovery of a novel natural compound, vitekwangin B, with ANO1 protein reduction properties and anticancer potential
Discovery of a novel natural compound, vitekwangin B, with ANO1 protein reduction properties and anticancer potential Open
Background: Prostate cancer and non-small cell lung cancer (NSCLC) present significant challenges in the development of effective therapeutic strategies. Hormone therapies for prostate cancer target androgen receptors and prostate-specific…
View article: Anticancer Effect of Verteporfin on Non-Small Cell Lung Cancer via Gradual Reduction of ANO1 Protein Levels
Anticancer Effect of Verteporfin on Non-Small Cell Lung Cancer via Gradual Reduction of ANO1 Protein Levels Open
Background and Purpose: Anoctamin 1 (ANO1) is a calcium-activated chloride channel found in various cell types and is overexpressed in non-small cell lung cancer (NSCLC), a major cause of cancer-related mortality. This study aimed to inves…
View article: Dopaminergic cell protection and alleviation of neuropsychiatric disease symptoms by<scp>VMAT2</scp>expression through the class I<scp>HDAC</scp>inhibitor<scp>TC‐H</scp>106
Dopaminergic cell protection and alleviation of neuropsychiatric disease symptoms by<span>VMAT2</span>expression through the class I<span>HDAC</span>inhibitor<span>TC‐H</span>106 Open
The importance of vesicular monoamine transporter 2 (VMAT2) in dopamine regulation, which is considered crucial for neuropsychiatric disorders, is currently being studied. Moreover, the development of disease treatments using histone deace…
View article: Cardiotoxicity assessment of 31 herbal formulae by activity of hERG potassium channel in HEK 293 cells
Cardiotoxicity assessment of 31 herbal formulae by activity of hERG potassium channel in HEK 293 cells Open
Objectives: Drug-induced blockade of the human ether-à-go-go related gene (hERG) potassium ion channel causes acquired long QT syndrome, which is known to cause cardiac arrhythmias and be fatal. To establish safety evidence of herbal formu…
View article: hERG Channel-Related Cardiotoxicity Assessment of 13 Herbal Medicines
hERG Channel-Related Cardiotoxicity Assessment of 13 Herbal Medicines Open
Objectives: As the use of herbal medicinal products (HMPs) increases worldwide, systematic verification of the safety of HMPs is required. The induction of cardiotoxicity is one of the major factors in post-approval withdrawal of medicinal…
View article: Diethylstilbestrol, a Novel ANO1 Inhibitor, Exerts an Anticancer Effect on Non-Small Cell Lung Cancer via Inhibition of ANO1
Diethylstilbestrol, a Novel ANO1 Inhibitor, Exerts an Anticancer Effect on Non-Small Cell Lung Cancer via Inhibition of ANO1 Open
Non-small cell lung cancer (NSCLC) is one of the leading causes of cancer-related mortality; thus, therapeutic targets continue to be developed. Anoctamin1 (ANO1), a novel drug target considered for the treatment of NSCLC, is a Ca2+-activa…
View article: Cardiac Safety Assessment of Medicinal Herbal Formulas Using hERG-HEK 293 cell
Cardiac Safety Assessment of Medicinal Herbal Formulas Using hERG-HEK 293 cell Open
Objectives The correlation between medicinal herbal formulas and a risk of cardiotoxicity has been controversial. Thus, this study investigated cardiac safety assessment of 52 most commonly used medicinal herbal formulas. Methods We evalua…
View article: Central peptidergic modulation of peripheral olfactory responses
Central peptidergic modulation of peripheral olfactory responses Open
Interestingly, this modulation of the peripheral odorant responsiveness of the ab3A neurons by NPF is distinct from the modulation of presynaptic gain in the ab3A neurons previously observed with the similarly named but distinct neuropepti…
View article: Additional file 7: of Central peptidergic modulation of peripheral olfactory responses
Additional file 7: of Central peptidergic modulation of peripheral olfactory responses Open
Data values for Figs. 3c and 6f. (XLSX 11 kb)