Siping Zhang
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View article: Genome-wide association analysis revealed that GhD6PKL2 regulates cold tolerance at seed germination and seedling emergence in cotton
Genome-wide association analysis revealed that GhD6PKL2 regulates cold tolerance at seed germination and seedling emergence in cotton Open
View article: Identified BIRC5 and HDAC1 as Novel Diagnostic Biomarkers Linked to Centrosome-Immune Crosstalk for Cutaneous Squamous Cell Carcinoma via Machine Learning-Based Multi-omics Analysis
Identified BIRC5 and HDAC1 as Novel Diagnostic Biomarkers Linked to Centrosome-Immune Crosstalk for Cutaneous Squamous Cell Carcinoma via Machine Learning-Based Multi-omics Analysis Open
Background Cutaneous squamous cell carcinoma (cSCC) is a common skin cancer where immune dysregulation plays a critical role in its progression and resistance to therapy. Centrosomal amplification (CA), a marker of genomic instability, con…
View article: Drought resistance cotton genotypes evaluation with multi-year & multi-site study
Drought resistance cotton genotypes evaluation with multi-year & multi-site study Open
To determine the agronomic traits closely related to the drought resistance of cotton, and the universal genotypes for drought resistance in cotton. The experiment was conducted in Alaer, Xinjiang Uygur Autonomous and Dunhuang, Gansu Provi…
View article: Antifungal resistance of the <i>Trichophyton mentagrophytes/Trichophyton interdigitale</i> species complex: Insights from the China Antifungal Resistance Dermatophytes Surveillance network Study (CARDS)
Antifungal resistance of the <i>Trichophyton mentagrophytes/Trichophyton interdigitale</i> species complex: Insights from the China Antifungal Resistance Dermatophytes Surveillance network Study (CARDS) Open
Background Dermatophytosis caused by the Trichophyton mentagrophytes/T. interdigitale species complex (TMTISC) has attracted global attention, with increasing reports of terbinafine‐resistant T. indotineae in China. Objectives This study a…
View article: Targeting efflux pumps prevents the multi-step evolution of high-level resistance to fluoroquinolone in <i>Pseudomonas aeruginosa</i>
Targeting efflux pumps prevents the multi-step evolution of high-level resistance to fluoroquinolone in <i>Pseudomonas aeruginosa</i> Open
Antibiotic resistance is emerging as a significant global health crisis, necessitating the urgent development of novel antibiotics or alternative therapies. Although it is recognized that bacteria require multiple mutations to develop resi…
View article: Efficacy and Safety of GR1802 in Patients With Moderate‐to‐Severe Atopic Dermatitis: A Multicenter, Randomized, Double‐Blind, Placebo‐Controlled Phase 2 Trial
Efficacy and Safety of GR1802 in Patients With Moderate‐to‐Severe Atopic Dermatitis: A Multicenter, Randomized, Double‐Blind, Placebo‐Controlled Phase 2 Trial Open
Background: GR1802 is a newly developed, fully humanized monoclonal antibody targeting the interleukin‐4 receptor alpha (IL‐4Rα) subunit, which is a component common to both the IL‐4 and IL‐13 receptor complexes. Objectives: Our objective …
View article: Integrative proteome and metabolome analyses reveal molecular basis of the tail resorption during the metamorphic climax of Nanorana pleskei
Integrative proteome and metabolome analyses reveal molecular basis of the tail resorption during the metamorphic climax of Nanorana pleskei Open
During the metamorphosis of anuran amphibians, the tail resorption process is a necessary and crucial change. One subject that has received relatively little or no attention is the expression patterns of proteins and metabolites in the dif…
View article: How fear emotion impacts collective motion in threat environment
How fear emotion impacts collective motion in threat environment Open
Introduction: The emergence of collective behavior often depends on the adequate interaction of individuals through self-organization and the exchange of local information. When facing external threats, communication among individuals requ…
View article: Effects of Different Irrigation Water Volumes with 1,1-Dimethyl-piperidinium Chloride (DPC) on Cotton Growth and Yield
Effects of Different Irrigation Water Volumes with 1,1-Dimethyl-piperidinium Chloride (DPC) on Cotton Growth and Yield Open
The cotton industry in Xinjiang, China, is limited by irrigation. In cotton production, 1,1-dimethyl-piperidinium chloride (DPC) is used as a growth regulator to improve plant shape, resistance, yield, and quality. However, few studies hav…
View article: The Contributions of Sub-Communities to the Assembly Process and Ecological Mechanisms of Bacterial Communities along the Cotton Soil–Root Continuum Niche Gradient
The Contributions of Sub-Communities to the Assembly Process and Ecological Mechanisms of Bacterial Communities along the Cotton Soil–Root Continuum Niche Gradient Open
Soil microbes are crucial in shaping the root-associated microbial communities. In this study, we analyzed the effect of the soil–root niche gradient on the diversity, composition, and assembly of the bacterial community and co-occurrence …
View article: Pseudomonas aeruginosa two-component system CprRS regulates HigBA expression and bacterial cytotoxicity in response to LL-37 stress
Pseudomonas aeruginosa two-component system CprRS regulates HigBA expression and bacterial cytotoxicity in response to LL-37 stress Open
Pseudomonas aeruginosa is a highly pathogenic bacterium known for its ability to sense and coordinate the production of virulence factors in response to host immune responses. However, the regulatory mechanisms underlying this process have…
View article: Research on the Threat of H5N1 Avian Influenza Virus to Chicken Health and Its Molecular Mechanisms
Research on the Threat of H5N1 Avian Influenza Virus to Chicken Health and Its Molecular Mechanisms Open
With the repeated outbreaks of the H5N1 avian influenza virus, in-depth research on its threat to chicken health and its molecular mechanism has become particularly urgent. This study aims to comprehensively analyze the characteristics and…
View article: Whole-Genome Association Analysis in Revealing the Application of Genetic Factors Affecting Livestock Production Traits
Whole-Genome Association Analysis in Revealing the Application of Genetic Factors Affecting Livestock Production Traits Open
This study reviews the application of whole-genome association analysis in revealing genetic factors affecting livestock production traits. With the continuous development of biotechnology and genomics, whole-genome association analysis ha…
View article: Genomic Prediction: Enhancing Breeding Strategies for Complex Traits in Livestock
Genomic Prediction: Enhancing Breeding Strategies for Complex Traits in Livestock Open
View article: A Brain-Inspired Spiking Neural Network for Efficient Sequence Memory
A Brain-Inspired Spiking Neural Network for Efficient Sequence Memory Open
View article: Drought Resistance Cotton Genotypes Evaluation with Multi-Year & Multi-Site Study
Drought Resistance Cotton Genotypes Evaluation with Multi-Year & Multi-Site Study Open
View article: Pro‐inflammatory cytokine IL‐6 regulates LMO4 expression in psoriatic keratinocytes via AKT/STAT3 pathway
Pro‐inflammatory cytokine IL‐6 regulates LMO4 expression in psoriatic keratinocytes via AKT/STAT3 pathway Open
The transcription factor LIM‐only protein 4 (LMO4) is overexpressed in the psoriatic epidermis and regulates keratinocyte proliferation and differentiation. High LMO4 expression levels are induced by interleukin‐23 (IL‐23) to activate the …
View article: Clinical application of 3D printing-assisted patient-specific instrument osteotomy guide in stiff clubfoot: preliminary findings
Clinical application of 3D printing-assisted patient-specific instrument osteotomy guide in stiff clubfoot: preliminary findings Open
View article: Antitoxin MqsA decreases antibiotic susceptibility through the global regulator AgtR in <i>Pseudomonas fluorescens</i>
Antitoxin MqsA decreases antibiotic susceptibility through the global regulator AgtR in <i>Pseudomonas fluorescens</i> Open
Type II toxin-antitoxin systems are highly prevalent in bacterial genomes and play crucial roles in the general stress response. Previously, we demonstrated that the type II antitoxin PfMqsA regulates biofilm formation through the global r…
View article: Effects of the Severe Acute Respiratory Syndrome Coronavirus 2 Inactivated Vaccine on the Outcome of Frozen Embryo Transfers: A Large Scale Clinical Study
Effects of the Severe Acute Respiratory Syndrome Coronavirus 2 Inactivated Vaccine on the Outcome of Frozen Embryo Transfers: A Large Scale Clinical Study Open
Pregnancy outcomes were not affected by taking the SARS-CoV-2 inactivated vaccine before FET, the number of doses, and the interval between doses. These findings provide evidence supporting the safety of administering the SARS-CoV-2 inacti…
View article: Injections of platelet‐rich plasma prepared by automatic blood cell separator combined with topical 5% minoxidil in the treatment of male androgenetic alopecia
Injections of platelet‐rich plasma prepared by automatic blood cell separator combined with topical 5% minoxidil in the treatment of male androgenetic alopecia Open
Background Platelet‐rich plasma (PRP) has been increasingly accepted as a potential therapy in the treatment of androgenetic alopecia (AGA), However, there remains a dearth of data on the effectiveness of PRP prepared by automatic blood ce…
View article: Functional and structural diversification of incomplete phosphotransferase system in cellulose-degrading clostridia
Functional and structural diversification of incomplete phosphotransferase system in cellulose-degrading clostridia Open
Carbohydrate utilization is critical to microbial survival. The phosphotransferase system (PTS) is a well-documented microbial system with a prominent role in carbohydrate metabolism, which can transport carbohydrates through forming a pho…
View article: The novel type II toxin–antitoxin PacTA modulates <i>Pseudomonas aeruginosa</i> iron homeostasis by obstructing the DNA-binding activity of Fur
The novel type II toxin–antitoxin PacTA modulates <i>Pseudomonas aeruginosa</i> iron homeostasis by obstructing the DNA-binding activity of Fur Open
Type II toxin–antitoxin (TA) systems are widely distributed in bacterial and archaeal genomes and are involved in diverse critical cellular functions such as defense against phages, biofilm formation, persistence, and virulence. GCN5-relat…
View article: Genome-wide association study identifies GhSAL1 conferring cold tolerance at the seeding stage in upland cotton (Gossypium hirsutum L.)
Genome-wide association study identifies GhSAL1 conferring cold tolerance at the seeding stage in upland cotton (Gossypium hirsutum L.) Open
Gossypium hirsutum L. is a globally cultivated cotton species. The genetic mechanisms underlying cold resistance in cotton remain unclear. We analyzed the growth and physiological parameters in 200 unrelated accessions under constant chill…
View article: A novel four‐gene signature predicts immunotherapy response of patients with different cancers
A novel four‐gene signature predicts immunotherapy response of patients with different cancers Open
Background Immune checkpoint blockade (ICB) therapy has demonstrated favorable clinical efficacy, particularly for advanced or difficult‐to‐treat cancer types. However, this therapy is ineffective for many patients displaying lack of immun…
View article: Molecular basis for coordinating secondary metabolite production by bacterial and plant signaling molecules
Molecular basis for coordinating secondary metabolite production by bacterial and plant signaling molecules Open
The production of secondary metabolites is a major mechanism used by beneficial rhizobacteria to antagonize plant pathogens. These bacteria have evolved to coordinate the production of different secondary metabolites due to the heavy metab…
View article: Biomechanical effects of fixed-bearing femoral prostheses with different coronal positions in medial unicompartmental knee arthroplasty
Biomechanical effects of fixed-bearing femoral prostheses with different coronal positions in medial unicompartmental knee arthroplasty Open
View article: Detection of Circulating VZV-Glycoprotein E-Specific Antibodies by Chemiluminescent Immunoassay (CLIA) for Varicella–Zoster Diagnosis
Detection of Circulating VZV-Glycoprotein E-Specific Antibodies by Chemiluminescent Immunoassay (CLIA) for Varicella–Zoster Diagnosis Open
Varicella and herpes zoster are mild symptoms-associated diseases caused by varicella–zoster virus (VZV). They often cause severe complications (disseminated zoster), leading to death when diagnoses and treatment are delayed. However, most…
View article: Hemodynamic analysis of intermittent pneumatic compression combined with hyperthermia after total hip arthroplasty: an experiment on male rabbits.
Hemodynamic analysis of intermittent pneumatic compression combined with hyperthermia after total hip arthroplasty: an experiment on male rabbits. Open
IPCH superimposes the effects of IPC and HT, and can more effectively promote changes in local blood circulation to prevent deep vein thrombosis.
View article: Ghmyb102 Promotes Drought Resistance in Cotton (Gossypium Hirsutum L.) by Regulating Drought-Responsive Genes and Aba Biosynthesis
Ghmyb102 Promotes Drought Resistance in Cotton (Gossypium Hirsutum L.) by Regulating Drought-Responsive Genes and Aba Biosynthesis Open