Shunda Du
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View article: Three-dimensional bioprinting of patient-derived Gastrointestinal stromal tumor: a novel platform for precision oncology and drug response profiling
Three-dimensional bioprinting of patient-derived Gastrointestinal stromal tumor: a novel platform for precision oncology and drug response profiling Open
Overall, the 3DP-GIST model represents a robust and efficient platform for evaluating patient-specific drug sensitivities in vitro, thereby guiding personalized therapeutic strategies for GIST patients.
View article: Rescue of extreme hepatectomy mice by primary hepatocyte-derived 3D bio-printed organ transplantation
Rescue of extreme hepatectomy mice by primary hepatocyte-derived 3D bio-printed organ transplantation Open
Three-dimensional (3D) bioprinting is an emerging strategy for constructing tissues and organs in vitro. Here, we achieved long-term expansion of primary mouse hepatocytes using a defined medium and constructed liver tissue using 3D biopri…
View article: Development of a machine learning-based prediction model for acute kidney injury associated with respiratory failure in the intensive care unit
Development of a machine learning-based prediction model for acute kidney injury associated with respiratory failure in the intensive care unit Open
Acute kidney injury (AKI) is a frequent and severe complication in intensive care unit (ICU) patients with respiratory failure, associated with high mortality, prolonged hospitalization, and substantial healthcare burden. Conventional risk…
View article: Exploring personalized prediction of clinical chemotherapy efficacy and revealing tumor heterogeneity using patient-derived 3D bioprinting gastric cancer models
Exploring personalized prediction of clinical chemotherapy efficacy and revealing tumor heterogeneity using patient-derived 3D bioprinting gastric cancer models Open
Background The pronounced chemotherapeutic heterogeneity observed in gastric cancer (GC) poses significant challenges to personalized treatment strategies, with current approaches lacking reliable predictive modalities for chemotherapy eff…
View article: Immunotherapy-Based Strategies versus Transcatheter Arterial Chemoembolization and the Impact of Treatment Duration in Hepatocellular Carcinoma with Microvascular Invasion: A Retrospective Multicenter Cohort Study
Immunotherapy-Based Strategies versus Transcatheter Arterial Chemoembolization and the Impact of Treatment Duration in Hepatocellular Carcinoma with Microvascular Invasion: A Retrospective Multicenter Cohort Study Open
Among patients with HCC and MVI following curative resection, adjuvant ICIs therapy provides a significant recurrence-free survival advantage over TACE. Treatment durations shorter than 12 months may be insufficient, supporting the benefit…
View article: FastLoader: Leveraging large language models to accelerate cargo loading optimization with numerous loading constraints
FastLoader: Leveraging large language models to accelerate cargo loading optimization with numerous loading constraints Open
With the unquestionable commercial success of air cargo transportation, cargo loading is a crucial step that selects the optimal placement solution for a given aircraft hold and a set of cargoes. This combinatorial optimization promotes ai…
View article: Adjuvant TACE Improves Prognosis After Resection in Dual-Phenotype Hepatocellular Carcinoma: A Propensity Score-Matched Study
Adjuvant TACE Improves Prognosis After Resection in Dual-Phenotype Hepatocellular Carcinoma: A Propensity Score-Matched Study Open
This study has been registered with the Chinese Clinical Trial Registry Center (ChiCTR2500103222).
View article: An innovative surgical approach using the hepatic falciform ligament to repair bronchobiliary fistula after radiofrequency ablation: a case report
An innovative surgical approach using the hepatic falciform ligament to repair bronchobiliary fistula after radiofrequency ablation: a case report Open
This case highlights a novel, minimally invasive, and effective surgical technique for treating BBF post-RFA, potentially reducing mortality and improving recovery in patients intolerant of extensive thoracoabdominal procedures.
View article: Global trends and future predictions of gastrointestinal ulcers in youth
Global trends and future predictions of gastrointestinal ulcers in youth Open
Background By analyzing past disease trends and comparing two time series statistical models, we can predict the global burden of gastrointestinal ulcers in specific populations of adolescents and young adults aged 10–24. This prediction c…
View article: RETRACTED: Exploring Personalized Prediction of Clinical Chemotherapy Efficacy and Revealing Tumor Heterogeneity Using Patient-Derived 3D Bioprinting Gastric Cancer Models
RETRACTED: Exploring Personalized Prediction of Clinical Chemotherapy Efficacy and Revealing Tumor Heterogeneity Using Patient-Derived 3D Bioprinting Gastric Cancer Models Open
The authors have requested that this preprint be removed from Research Square.
View article: Combined TACE with Targeted and Immunotherapy versus TACE Alone Improves DFS in HCC with MVI: A Multicenter Propensity Score Matching Study
Combined TACE with Targeted and Immunotherapy versus TACE Alone Improves DFS in HCC with MVI: A Multicenter Propensity Score Matching Study Open
In HCC patients with MVI, adjuvant TACE combined with targeted therapy or targeted immunotherapy significantly enhances DFS, though no OS benefit was observed. The developed nomogram provides a reliable tool for risk stratification and per…
View article: A prolonged activated partial thromboplastin time indicates poor short-term prognosis in patients with hepatic encephalopathy: insights from the MIMIC database
A prolonged activated partial thromboplastin time indicates poor short-term prognosis in patients with hepatic encephalopathy: insights from the MIMIC database Open
Objectives This study investigates serum markers for short-term prognosis in hepatic encephalopathy patients. Background Patients with hepatic encephalopathy face elevated mortality rates and bleak prognoses. However, effective prognostic …
View article: Association between post-COVID-19 sleep disturbance and neurocognitive function: a comparative study based on propensity score matching
Association between post-COVID-19 sleep disturbance and neurocognitive function: a comparative study based on propensity score matching Open
Despite that sleep disturbance and poor neurocognitive performance are common complaints among coronavirus disease 2019 (COVID-19) survivors, few studies have focused on the effect of post-COVID-19 sleep disturbance (PCSD) on cognitive fun…
View article: 2024 latest report on hepatitis B virus epidemiology in China: current status, changing trajectory, and challenges
2024 latest report on hepatitis B virus epidemiology in China: current status, changing trajectory, and challenges Open
Hepatitis B virus (HBV) infection is a significant global public health concern, particularly in China, which accounts for one-third of the world's chronic HBV cases. Over the past three decades, China has made substantial progress in cont…
View article: Body Roundness Index Z-Scores and Hypertension
Body Roundness Index Z-Scores and Hypertension Open
Introduction: Hypertension is a global health concern and a leading risk factor for cardiovascular diseases. Central obesity, marked by abdominal fat, is more strongly linked to hypertension than general obesity. Traditional metrics like B…
View article: Chinese expert consensus on sequential surgery following conversion therapy based on combination of immune checkpoint inhibitors and antiangiogenic targeted drugs for advanced hepatocellular carcinoma (2024 edition)
Chinese expert consensus on sequential surgery following conversion therapy based on combination of immune checkpoint inhibitors and antiangiogenic targeted drugs for advanced hepatocellular carcinoma (2024 edition) Open
Up to half of hepatocellular carcinoma (HCC) cases are diagnosed at an advanced stage, for which effective treatment options are lacking, resulting in a poor prognosis. Over the past few years, the combination of immune checkpoint inhibito…
View article: An index structure supporting efficient querying of historical transactions on the blockchain
An index structure supporting efficient querying of historical transactions on the blockchain Open
Blockchain technology is increasingly being utilized in the field of digital assets, especially in asset tracking and traceability. In order to ensure the efficiency of asset tracking and traceability, it is necessary to improve the effici…
View article: Chinese guidelines for minimally invasive donor hepatectomy in living donor liver transplantation (2024 edition)
Chinese guidelines for minimally invasive donor hepatectomy in living donor liver transplantation (2024 edition) Open
The formulation of these guidelines represents a significant advancement towards standardizing minimally invasive liver transplantation surgeries in China. They are designed to enhance outcomes for both donors and recipients by synthesizin…
View article: Chinese Expert Consensus on the Combination of Targeted Therapy and Immunotherapy with Locoregional Therapy for Intermediate/Advanced Hepatocellular Carcinoma
Chinese Expert Consensus on the Combination of Targeted Therapy and Immunotherapy with Locoregional Therapy for Intermediate/Advanced Hepatocellular Carcinoma Open
Hepatocellular carcinoma (HCC) is a major cause of cancer-related mortality; it ranks as the second most common cause of cancer deaths in China. Most HCC patients are first diagnosed at an advanced stage. In recent years, targeted therapy …
View article: A bibliometric analysis of oncolytic virotherapy combined with immunotherapy
A bibliometric analysis of oncolytic virotherapy combined with immunotherapy Open
Oncolytic virotherapy in combination with immunotherapy has demonstrated significant survival benefits in some types of cancer. Here, we summarized the development, research hotpots and potential trends of the combination therapy using vis…
View article: Novel multifactor predictive model for postoperative survival in gallbladder cancer: a multi-center study
Novel multifactor predictive model for postoperative survival in gallbladder cancer: a multi-center study Open
The novel nomogram exhibited good prognostic efficacy and robust generalizability in GBC patients, which might be a promising tool for aiding clinical decision-making.
View article: Developing Patient-Derived 3D-Bioprinting models of pancreatic cancer
Developing Patient-Derived 3D-Bioprinting models of pancreatic cancer Open
The PC 3DP models demonstrated their utility as reliable preclinical tools, retaining key genomic and histological characteristics. Importantly, drug sensitivity profiles in these models showed potential correlations with clinical outcomes…