Siqi Hu
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View article: Predicting host tropism in influenza a viruses: insights from multi-segment nucleotide signatures
Predicting host tropism in influenza a viruses: insights from multi-segment nucleotide signatures Open
This study advances our mechanistic understanding of IAV host adaptation, identifies molecular determinants for zoonotic risk stratification, and establishes a scalable machine learning framework for predicting viral host tropism through n…
View article: Medication use in the neonatal intensive care unit in a tertiary hospital in China from 2020 to 2023
Medication use in the neonatal intensive care unit in a tertiary hospital in China from 2020 to 2023 Open
Our retrospective study will not only help identify and evaluate interventions to reduce medication errors but also aid healthcare systems and providers in understanding, implementing, and enhancing these interventions to improve the safet…
View article: <b>An alternatively translated isoform of </b><b><i>PPARG</i></b><b> proposes AF-1 domain inhibition as an insulin sensitization target</b>
<b>An alternatively translated isoform of </b><b><i>PPARG</i></b><b> proposes AF-1 domain inhibition as an insulin sensitization target</b> Open
PPARγ is the pharmacological target of thiazolidinediones (TZDs), potent insulin sensitizers that prevent metabolic disease morbidity but are accompanied by side effects such as weight gain, in part due to non-physiological transcriptional…
View article: <b>An alternatively translated isoform of </b><b><i>PPARG</i></b><b> proposes AF-1 domain inhibition as an insulin sensitization target</b>
<b>An alternatively translated isoform of </b><b><i>PPARG</i></b><b> proposes AF-1 domain inhibition as an insulin sensitization target</b> Open
PPARγ is the pharmacological target of thiazolidinediones (TZDs), potent insulin sensitizers that prevent metabolic disease morbidity but are accompanied by side effects such as weight gain, in part due to non-physiological transcriptional…
View article: Echoes in the Deep: Revealing Influenza A Viruses’ Persistence and Microbial Associations in Aquatic Ecosystems
Echoes in the Deep: Revealing Influenza A Viruses’ Persistence and Microbial Associations in Aquatic Ecosystems Open
Background Influenza A viruses (IAVs) are significant pathogens with complex transmission dynamics in aquatic ecosystems, yet their persistence, evolutionary relationships, and associations with environmental microorganisms remain poorly u…
View article: Gene flow and its sporadic spillover: H10 and N5 avian influenza viruses from wild birds and the H10N5 human cases in China
Gene flow and its sporadic spillover: H10 and N5 avian influenza viruses from wild birds and the H10N5 human cases in China Open
On January 30, 2024, China announced the first human case of H10N5 influenza infection. Prior to this, human cases of H10N7 and H10N8 had been reported. It is now appropriate to re-examine the evolution and future epidemiological trends of…
View article: Development and evaluation of a CRISPR/Cas12a-based diagnostic test for rapid detection and genotyping of HR-HPV in clinical specimens
Development and evaluation of a CRISPR/Cas12a-based diagnostic test for rapid detection and genotyping of HR-HPV in clinical specimens Open
Persistent infection with high-risk human papillomavirus (HR-HPV) is the principal etiological factor of cervical cancer. Considering the gradual progression of cervical cancer, the early, rapid, sensitive, and specific identification of H…
View article: Synergistic peptide combinations designed to suppress SARS-CoV-2
Synergistic peptide combinations designed to suppress SARS-CoV-2 Open
The SARS-CoV-2, responsible for the COVID-19 pandemic, poses a significant threat to global healthcare. Peptide and peptide-based inhibitors, known for their safety, efficacy, and selectivity, have recently emerged as promising candidates …
View article: The influence of the COVID‐19 pandemic on the spectrum of neonatal disease in a tertiary hospital in China: A retrospective analysis
The influence of the COVID‐19 pandemic on the spectrum of neonatal disease in a tertiary hospital in China: A retrospective analysis Open
Background and Aims Neonatal diseases are a significant threat to global public health, affecting the homeostasis and well‐being of patients and reflecting the status of, and challenges to, regional, national, and global healthcare systems…
View article: Clinical profile of congenital heart diseases detected in a tertiary hospital in China: a retrospective analysis
Clinical profile of congenital heart diseases detected in a tertiary hospital in China: a retrospective analysis Open
Background Congenital heart diseases (CHDs) are conditions that involve structural problems to the heart's structure existing at birth, with an incidence of approximately 8 per 1,000 live births globally. CHD is one of the leading causes o…
View article: The influence of the COVID-19 pandemic on the spectrum of neonatal disease in a tertiary hospital in China
The influence of the COVID-19 pandemic on the spectrum of neonatal disease in a tertiary hospital in China Open
Background: Neonatal diseases are a significant threat to global public health, resulting in the disturbance of normal homeostatic well-being in affected patients and reflecting the status of, and challenges to, regional, national, and glo…
View article: The research on the treatment of primary immunodeficiency diseases by hematopoietic stem cell transplantation: A bibliometric analysis from 2013 to 2022
The research on the treatment of primary immunodeficiency diseases by hematopoietic stem cell transplantation: A bibliometric analysis from 2013 to 2022 Open
Hematopoietic stem cell transplantation (HSCT) is curative in patients with primary immunodeficiency syndrome. The safety and efficacy of HSCT as a therapeutic option for primary immunodeficiency diseases (PID) have been studied by many re…
View article: Case Report: Identification of Two Variants of ALG13 in Families With or Without Seizure and Binocular Strabismus: Phenotypic Spectrum Analysis
Case Report: Identification of Two Variants of ALG13 in Families With or Without Seizure and Binocular Strabismus: Phenotypic Spectrum Analysis Open
Background: Genetic causes in most affected children with intellectual disability and/or development delay remain unknown. Methods: To identify potential variants responsible for these disorders, we recruited 161 affected families and perf…
View article: Chip-integrated van der Waals PN heterojunction photodetector with low dark current and high responsivity
Chip-integrated van der Waals PN heterojunction photodetector with low dark current and high responsivity Open
Two-dimensional materials are attractive for constructing high-performance photonic chip-integrated photodetectors because of their remarkable electronic and optical properties and dangling-bond-free surfaces. However, the reported chip-in…
View article: A Nuclear Export Signal Is Required for cGAS to Sense Cytosolic DNA
A Nuclear Export Signal Is Required for cGAS to Sense Cytosolic DNA Open
The cyclic GMP-AMP (cGAMP) synthase (cGAS) is a key DNA sensor that initiates STING-dependent signaling to produce type I interferons through synthesizing the secondary messenger 2'3'-cGAMP. In this study, we confirm previous studies showi…
View article: Metabolomic analysis of serum and placenta in preeclampsia
Metabolomic analysis of serum and placenta in preeclampsia Open
Background: Preeclampsia (PE) is one of the main causes of maternal and fetal morbidity and mortality worldwide. This study was aimed to explore the potential metabolic alterations in women diagnosed with PE and reveal the underlying patho…
View article: Evaluation of autoantibodies and immunoglobulin G subclasses in women with suspected macroprolactinemia
Evaluation of autoantibodies and immunoglobulin G subclasses in women with suspected macroprolactinemia Open
Background Macroprolactin mostly composed of an immunoglobulin G (IgG) and a monomeric prolactin (PRL) represents the major circulating PRL form in the patients with macroprolactinemia that are usually asymptomatic and may not require trea…
View article: CRISPR-Cas13a Inhibits HIV-1 Infection
CRISPR-Cas13a Inhibits HIV-1 Infection Open
CRISPR-Cas provides bacteria and archaea with immunity against invading phages and foreign plasmid DNA and has been successfully adapted for gene editing in a variety of species. The class 2 type VI CRISPR-Cas effector Cas13a targets and c…
View article: Influenza Virus Exploits an Interferon-Independent lncRNA to Preserve Viral RNA Synthesis through Stabilizing Viral RNA Polymerase PB1
Influenza Virus Exploits an Interferon-Independent lncRNA to Preserve Viral RNA Synthesis through Stabilizing Viral RNA Polymerase PB1 Open
Long noncoding RNAs (lncRNAs) participate in host antiviral defense by modulating immune responses. However, it remains largely unexplored how viruses exploit interferon (IFN)-independent host lncRNAs to facilitate viral replication. Here,…
View article: Amphotericin B Inhibits Enterovirus 71 Replication by Impeding Viral Entry
Amphotericin B Inhibits Enterovirus 71 Replication by Impeding Viral Entry Open
Enterovirus 71 (EV71) infection causes hand-foot-and-mouth disease that leads to cardiopulmonary complications and death in young children. There is thus an urgent need to find new treatments to control EV71 infection. In this study, we re…