Sirui Chen
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View article: Multiomic insights into the MPO-mediated NET formation pathway in alcohol-induced epilepsy risk
Multiomic insights into the MPO-mediated NET formation pathway in alcohol-induced epilepsy risk Open
View article: The Therapeutic Potential of Farm Dust Extracts in a Mouse Model of Eosinophilic Inflammation
The Therapeutic Potential of Farm Dust Extracts in a Mouse Model of Eosinophilic Inflammation Open
Background Asthma affects over 355 million people globally and poses a major healthcare burden. While corticosteroids remain a cornerstone of treatment, their side effects highlight the need for additional therapeutic strategies. Environme…
View article: Beyond energy metabolism: ketogenic diet and β-hydroxybutyrate protect against intestinal ischemia-reperfusion injury through anti-inflammatory and barrier-preserving effects
Beyond energy metabolism: ketogenic diet and β-hydroxybutyrate protect against intestinal ischemia-reperfusion injury through anti-inflammatory and barrier-preserving effects Open
Intestinal ischemia-reperfusion injury (IRI) is a significant clinical challenge with limited effective treatments. This study investigated the protective effects of ketogenic diet (KD) and β-hydroxybutyrate (BHB) against intestinal IRI us…
View article: Exploring Consciousness in LLMs: A Systematic Survey of Theories, Implementations, and Frontier Risks
Exploring Consciousness in LLMs: A Systematic Survey of Theories, Implementations, and Frontier Risks Open
Consciousness stands as one of the most profound and distinguishing features of the human mind, fundamentally shaping our understanding of existence and agency. As large language models (LLMs) develop at an unprecedented pace, questions co…
View article: Transcriptome analysis of insecticide resistance mechanisms in field populations of the bean flower thrips, Megalurothrips usitatus (Bagnall)
Transcriptome analysis of insecticide resistance mechanisms in field populations of the bean flower thrips, Megalurothrips usitatus (Bagnall) Open
The bean flower thrips, Megalurothrips usitatus (Bagnall), has caused significant damage to leguminous crops in the Asian tropics and established populations in North America. Ineffective pest control has been reported in multiple regions,…
View article: Exploring the value of blood urea nitrogen-to-albumin ratio in patients with acute pancreatitis admitted to the intensive care unit: a retrospective cohort study
Exploring the value of blood urea nitrogen-to-albumin ratio in patients with acute pancreatitis admitted to the intensive care unit: a retrospective cohort study Open
Background Although blood urea nitrogen and albumin alone are well-known clinical indicators, combining them as the blood urea nitrogen-to-albumin ratio (BAR) may provide additional prognostic information because they reflect the complex i…
View article: RAG over Tables: Hierarchical Memory Index, Multi-Stage Retrieval, and Benchmarking
RAG over Tables: Hierarchical Memory Index, Multi-Stage Retrieval, and Benchmarking Open
Retrieval-Augmented Generation (RAG) enhances Large Language Models (LLMs) by integrating them with an external knowledge base to improve the answer relevance and accuracy. In real-world scenarios, beyond pure text, a substantial amount of…
View article: Decoding Intrinsic Fluctuations of Engagement From EEG Signals During Fingertip Motor Tasks
Decoding Intrinsic Fluctuations of Engagement From EEG Signals During Fingertip Motor Tasks Open
Maintaining a high mental engagement is critical for motor rehabilitation interventions. Achieving a flow experience, often conceptualized as a highly engaged mental state, is an ideal goal for motor rehabilitation tasks. This paper propos…
View article: Transcriptome Analysis of Insecticide Resistance Mechanisms in Field Populations of the Bean Flower Thrips, Megalurothrips Usitatus (Bagnall)
Transcriptome Analysis of Insecticide Resistance Mechanisms in Field Populations of the Bean Flower Thrips, Megalurothrips Usitatus (Bagnall) Open
View article: Economic Analysis and Development Prospects of Green Methanol under the Background of Carbon Emission Reduction
Economic Analysis and Development Prospects of Green Methanol under the Background of Carbon Emission Reduction Open
With increasing attention to climate issues, the development of green energy has become a growing focus. Green methanol, as a potential clean energy source, can not only significantly reduce carbon dioxide emissions but also utilize carbon…
View article: The associations between oxidative stress and epilepsy: a bidirectional two-sample Mendelian randomization study
The associations between oxidative stress and epilepsy: a bidirectional two-sample Mendelian randomization study Open
View article: Analyzing particulate matter characteristics of the subway system: Case study of Guangzhou
Analyzing particulate matter characteristics of the subway system: Case study of Guangzhou Open
This study aims to: (1) evaluate the concentration distribution of particulate matter in the Guangzhou metro system; (2) Compare particulate matter concentrations under different conditions, including time, season, location, subway lines, …
View article: Solar tracking cycle charger system based on IPSO-DE
Solar tracking cycle charger system based on IPSO-DE Open
Aiming to address the problem of resource waste in the photovoltaic industry chain, a solar tracking cycle charger based on IPSO-DE has been designed. The device converts solar energy into electricity through solar photovoltaic panels and …
View article: Association between triglyceride to high-density lipoprotein cholesterol ratio and nonalcoholic fatty liver disease and liver fibrosis in American adults: an observational study from the National Health and Nutrition Examination Survey 2017–2020
Association between triglyceride to high-density lipoprotein cholesterol ratio and nonalcoholic fatty liver disease and liver fibrosis in American adults: an observational study from the National Health and Nutrition Examination Survey 2017–2020 Open
Objective This study investigated the link between triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio and nonalcoholic fatty liver disease (NAFLD) and liver fibrosis in American adults. Methods Information for 6495 parti…
View article: naRNA-LL37 composite DAMPs define sterile NETs as self-propagating drivers of inflammation
naRNA-LL37 composite DAMPs define sterile NETs as self-propagating drivers of inflammation Open
Neutrophil extracellular traps (NETs) are a key antimicrobial feature of cellular innate immunity mediated by polymorphonuclear neutrophils (PMNs). NETs counteract microbes but are also linked to inflammation in atherosclerosis, arthritis,…
View article: STAS: Spatial-Temporal Return Decomposition for Solving Sparse Rewards Problems in Multi-agent Reinforcement Learning
STAS: Spatial-Temporal Return Decomposition for Solving Sparse Rewards Problems in Multi-agent Reinforcement Learning Open
Centralized Training with Decentralized Execution (CTDE) has been proven to be an effective paradigm in cooperative multi-agent reinforcement learning (MARL). One of the major challenges is credit assignment, which aims to credit agents by…
View article: From GPT-4 to Gemini and Beyond: Assessing the Landscape of MLLMs on Generalizability, Trustworthiness and Causality through Four Modalities
From GPT-4 to Gemini and Beyond: Assessing the Landscape of MLLMs on Generalizability, Trustworthiness and Causality through Four Modalities Open
Multi-modal Large Language Models (MLLMs) have shown impressive abilities in generating reasonable responses with respect to multi-modal contents. However, there is still a wide gap between the performance of recent MLLM-based applications…
View article: Distribution characteristic and risk assessment of acid volatile sulfide and heavy metals in sulfate-rich reservoir sediment
Distribution characteristic and risk assessment of acid volatile sulfide and heavy metals in sulfate-rich reservoir sediment Open
随着湖库外源性污染的有效控制,沉积物污染特征成为影响湖库水环境质量的关键因素。本文以富硫型水库——汤河水库为研究对象,分析探讨水库沉积物的理化性质、重金属总量、酸可挥发性硫化物(acid volatile sulfide,AVS)和同步提取重金属(simultaneously extracted metals,SEM)的空间分布特征,采用沉积物基准法(sediment quality guidelines, SQGs)和AVS与SEM关系法对重金属可能诱发的生态风险和毒性效…
View article: Knockdown of GNL3L Alleviates the Progression of COPD Through Inhibiting the ATM/p53 Pathway
Knockdown of GNL3L Alleviates the Progression of COPD Through Inhibiting the ATM/p53 Pathway Open
GNL3L is a novel biomarker of COPD, and knockdown of GNL3L participates in the progression of COPD by inhibiting ATM/p53 pathway.
View article: Tracking dynamic flow: Decoding flow fluctuations through performance in a fine motor control task
Tracking dynamic flow: Decoding flow fluctuations through performance in a fine motor control task Open
Flow, an optimal mental state merging action and awareness, significantly impacts our emotion, performance, and well-being. However, capturing its swift fluctuations on a fine timescale is challenging due to the sparsity of the existing fl…
View article: AFF4 regulates osteogenic potential of human periodontal ligament stem cells via mTOR‐ULK1‐autophagy axis
AFF4 regulates osteogenic potential of human periodontal ligament stem cells via mTOR‐ULK1‐autophagy axis Open
Scaffold protein AF4/FMR2 family member 4 (AFF4) has been found to play a role in osteogenic commitment of stem cells. However, function of AFF4 in human periodontal ligament stem cells (hPDLSCs) has not been studied yet. This present stud…
View article: STAS: Spatial-Temporal Return Decomposition for Multi-agent Reinforcement Learning
STAS: Spatial-Temporal Return Decomposition for Multi-agent Reinforcement Learning Open
Centralized Training with Decentralized Execution (CTDE) has been proven to be an effective paradigm in cooperative multi-agent reinforcement learning (MARL). One of the major challenges is credit assignment, which aims to credit agents by…
View article: Psychometric evaluation of the academic involution scale for college students in China: An application of Rasch analysis
Psychometric evaluation of the academic involution scale for college students in China: An application of Rasch analysis Open
Recent academic attention on educational involution in China underpins the need for a valid and reliable instrument to precisely measure college students’ academic involution behaviors. Seeing the scarcity of a proper instrument, the curre…
View article: Cyclic di-adenosine monophosphate regulates the osteogenic and adipogenic differentiation of hPDLSCs via MAPK and NF-κB signaling
Cyclic di-adenosine monophosphate regulates the osteogenic and adipogenic differentiation of hPDLSCs via MAPK and NF-κB signaling Open
Cyclic di-adenosine monophosphate (c-di-AMP) is a bacterial second messenger that can be recognized by infected host cells and activate the immunoinflammatory response. The purpose of this study is to demonstrate the effect of c-di-AMP on …
View article: Arsenic and Heavy Metals in Sediments Affected by Typical Gold Mining Areas in Southwest China: Accumulation, Sources and Ecological Risks
Arsenic and Heavy Metals in Sediments Affected by Typical Gold Mining Areas in Southwest China: Accumulation, Sources and Ecological Risks Open
Gold mining is associated with serious heavy metal pollution problems. However, the studies on such pollution caused by gold mining in specific geological environments and extraction processes remain insufficient. This study investigated t…
View article: Uridine Diphosphate Glucosyltransferases are Involved in Spinosad Resistance in Western Flower Thrips, Frankliniella Occidentalis (Pergande)
Uridine Diphosphate Glucosyltransferases are Involved in Spinosad Resistance in Western Flower Thrips, Frankliniella Occidentalis (Pergande) Open
View article: Targeted pharmacokinetics and bioinformatics screening strategy reveals JAK2 as the main target for Xin-Ji-Er-Kang in treatment of MIR injury
Targeted pharmacokinetics and bioinformatics screening strategy reveals JAK2 as the main target for Xin-Ji-Er-Kang in treatment of MIR injury Open
View article: Rewired Metabolism of Amino Acids and Its Roles in Glioma Pathology
Rewired Metabolism of Amino Acids and Its Roles in Glioma Pathology Open
Amino acids (AAs) are indispensable building blocks of diverse bio-macromolecules as well as functional regulators for various metabolic processes. The fact that cancer cells live with a voracious appetite for specific AAs has been widely …
View article: The median effective doses of propofol combined with two different doses of nalbuphine for adult patients during painless gastroscopy
The median effective doses of propofol combined with two different doses of nalbuphine for adult patients during painless gastroscopy Open
Objective: Propofol is the most widely administered intravenous anesthetic to induce deep sedation for gastroscopy procedures. Coadministration of nalbuphine can provide analgesia and sedation to patients experiencing visceral pain, thereb…
View article: Connective tissue growth factor promotes cementogenesis and cementum repair via Cx43/β-catenin axis
Connective tissue growth factor promotes cementogenesis and cementum repair via Cx43/β-catenin axis Open