Explanipedia

Long Noncoding RNAs TYMSOS, VASH1-AS1, and LINC01001 Expressions as Biomarkers of β-thalassaemia Severity Among the Malaysian Patients Open

Norafiza Mohd Yasin, Nur Fatin Aqilah Raman, Siti Aishah Sulaiman, Nurhairulamri Kosnan, Nor Azian Abdul Murad , et al. · 2025

BACKGROUND: β-thalassaemia has heterogeneous disease severities ranging from mild to trait, and major. Long noncoding RNAs (lncRNAs) are known to regulate microRNAs (miRNAs) and genes, possibly modifying the disease phenotypes. However, li…

Economic evaluation of quantitative point-of-care testing versus spectrophotometric assay for population screening of glucose-6-phosphate dehydrogenase deficiency in Malaysia: A time-driven activity-based cost analysis Open

Mohamed Afiq Hidayat Zailani, Raja Zahratul Azma Raja Sabudin, Aniza Ismail, Mohamad Baihaqi Basri, Azlin Ithnin , et al. · 2025

Background: Glucose-6-phosphate dehydrogenase deficiency (G6PDd) is a common genetic disorder that can lead to life-threatening complications, including acute hemolytic anemia. Effective screening using advanced technology, such as point-o…

G6PD deficiency in Malaysia’s Proto-Malay Orang Asli indigenous population: A molecular and epidemiological study Open

Mohamed Afiq Hidayat Zailani, Raja Zahratul Azma Raja Sabudin, Muhammad‐Redha Abdullah‐Zawawi, Azlin Ithnin, Hafiza Alauddin , et al. · 2025

Glucose-6-phosphate dehydrogenase deficiency (G6PDd) is one of the most common genetic disorders worldwide and remains highly prevalent in malaria-endemic regions. Individuals with G6PDd are at risk of severe complications, including acute…

Gene co-expression module study identifies key genes and pathways underpinning hypercholesterolemia-induced atherosclerosis development Open

Muhammad‐Redha Abdullah‐Zawawi, Muhammad Irfan Abdul Jalal, Siti Aishah Sulaiman, Nur Alyaa Afifah Md Shahri, Rahman Jamal , et al. · 2025

Background Familial hypercholesterolemia (FH) is a significant risk factor for atherosclerosis due to elevated levels of low-density lipoprotein (LDL) cholesterol in arterial walls. This study aimed to determine the key genes involved in t…

Analysis of The Low-Density Lipoprotein Receptor (LDLR) Gene Among Family Hypercholesterolemia (FH) Patients in Malaysia: A Case Study Open

Zam Zureena Mohd Rani, Muhammad‐Redha Abdullah‐Zawawi, Norlaila Mustafa, Izzatul ‘Alia Baharuddin, Siti Aishah Sulaiman , et al. · 2025

Hiperkolesterolemia Familial (FH) adalah penyakit metabolisme lipoprotein yang menyebabkan peningkatan paras lipoprotein berketumpatan rendah (LDL-C) dalam darah sejak lahir. FH diwarisi secara autosomal dominan melalui mutasi gen LDLR, AP…

Genetics of type 2 diabetes (T2D) in Malaysia: a review Open

Nurul Humaira Mohd Redzuan, Siti Aishah Sulaiman, Nor Azian Abdul Murad, Norfazilah Ahmad, Chim C. Lang , et al. · 2025

Type 2 diabetes (T2D) is a significant public health concern in Malaysia, with rising prevalence across its multi-ethnic population. Genetic predisposition plays a key role in the development of T2D, but studies focusing on Malaysian popul…

Genetic screening of malay familial hypercholesterolemia patient for LDLRAP1/PCSK9/APOB mutations via whole exome sequencing Open

Muhammad‐Redha Abdullah‐Zawawi, Zam Zureena Mohd Rani, Nur Syakeera Seeni Ahamed Mydeen, Ryia Illani Mohd Yunos, Siti Aishah Sulaiman , et al. · 2025

Background Familial Hypercholesterolemia (FH) is a hereditary lipid disorder with an autosomal dominant genetic inheritance, characterized by high low-density lipoprotein cholesterol (LDL-C) levels and premature atherosclerosis. An elevate…

Study on the Potential of MARDI Specialty Rice for the Production of Local Parboiled Rice Open

Amir Syariffuddeen Mhd Adnan, Jeeven Karruppan, Siti Aishah Sulaiman, Nurhidayatulalia Sanusi, Siti Aisyah Sanusi , et al. · 2025

Producing specialty rice varieties with unique qualities is an essential research focus at MARDI. Additionally, producing parboiled rice from local specialty varieties adds value to the rice industry. This study evaluated two local special…

Fabrication and surface modification of direct growth graphene FET for DNA mutation-detection Open

Roharsyafinaz Roslan, Ahmad Ghadafi Ismail, Siti Aishah Sulaiman, Nor Azian Abdul Murad, Hashima Hamid , et al. · 2025

Whole Exome Sequencing of a Rare Disease, Mullerian Agenesis and Anorectal Anomaly: A Case Report Open

Siti Aishah Sulaiman, Nor Azian Abdul Murad, Chow Yock Ping, uhammad-Redha Abdullah-Zawawi, Zam Zureena Mohd Rani , et al. · 2024

Mullerian agenesis or Mayer-Rokitansky-Kuster-Hauser Syndrome (MRKH) Type-II is a congenital defect in the Mullerian duct that results in the absence of a uterus in women. The aetiology of this syndrome is unknown and has been considered a…

Development of DNA-Based Lateral Flow Assay for Detection of LDLR Gene Mutation for Familial Hypercholesterolemia Open

Lina Khalida Saidi, Zam Zureena Md Rani, Siti Aishah Sulaiman, Rahman Jamal, Ismail Aziah , et al. · 2024

Background: The techniques for detecting single nucleotide polymorphisms (SNP) require lengthy and complex experimental procedures and expensive instruments that may only be available in some laboratories. Thus, a deoxyribonucleic acid (DN…

Comprehensive Analysis of microRNA Methylation Profiles and Determination of Their Functional Significance in Colorectal Cancer: A Study Protocol Open

Nurul‐Syakima Ab Mutalib, Imilia Ismail, Muhammad‐Redha Abdullah‐Zawawi, Nadiah Abu, Siti Aishah Sulaiman , et al. · 2023

Colorectal cancer (CRC) is a leading cause of cancer-associated fatalities globally. Despite the notable progress in diagnostics and patient care, challenges persist in areas such as early detection, prognostic variable identification, met…

Geometrical Characterisation of TiO2-rGO Field-Effect Transistor as a Platform for Biosensing Applications Open

Anis Amirah Alim, Roharsyafinaz Roslan, Sh. Nadzirah, Lina Khalida Saidi, P. Susthitha Menon , et al. · 2023

The performance of the graphene-based field-effect transistor (FET) as a biosensor is based on the output drain current (Id). In this work, the signal-to-noise ratio (SNR) was investigated to obtain a high-performance device that produces …

Evaluation of Physical Quality Characterization MRQ 107 Parboil Rice Production Using Selected Parameter Open

Amir Syariffuddeen Mhd Adnan, Jeevan Karruppan, Hanisa Hosni, Engku Hasmah Engku Abdullah, Siti Aishah Sulaiman , et al. · 2023

Rice (Oryza sativa L.) is a significant source of nourishment in most Asian countries since it is a primary source of carbohydrates, micronutrients (Fe and Zn) and vitamins, offering broad prospects for food and nutritional security. MARDI…

Population screening for glucose-6-phosphate dehydrogenase deficiency using quantitative point-of-care tests: a systematic review Open

Mohamed Afiq Hidayat Zailani, Raja Zahratul Azma Raja Sabudin, Azlin Ithnin, Hafiza Alauddin, Siti Aishah Sulaiman , et al. · 2023

Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked hereditary disorder and a global public health concern that is most prevalent in malaria-endemic regions including Asia, Africa, and the Mediterranean. G6PD-def…

Hypercholesterolemia in the Malaysian Cohort Participants: Genetic and Non-Genetic Risk Factors Open

Nor Azian Abdul Murad, Yusuf Mohammad Noor, Zam Zureena Mohd. Rani, Siti Aishah Sulaiman, Yock Ping Chow , et al. · 2023

Hypercholesterolemia was prevalent in 44.9% of The Malaysian Cohort participants, of which 51% were Malay. This study aimed to identify the variants involved in hypercholesterolemia among Malays and to determine the association between gen…

Genetic Polymorphisms and Diversity in Nonalcoholic Fatty Liver Disease (NAFLD): A Mini Review Open

Siti Aishah Sulaiman, Vicneswarry Dorairaj, Muhammad Nafiz Haidi Adrus · 2022

Nonalcoholic fatty liver disease (NAFLD) is a common liver disease with a wide spectrum of liver conditions ranging from hepatic steatosis to nonalcoholic steatohepatitis (NASH), fibrosis, cirrhosis, and hepatocellular carcinoma. The preva…

Editorial: Genetic and molecular diversity in Parkinson's disease Open

Nor Azian Abdul Murad, Siti Aishah Sulaiman, Azlina Ahmad‐Annuar, Norlinah Mohamed Ibrahim, Wael Mohamed , et al. · 2022

EDITORIAL article Front. Aging Neurosci., 16 December 2022Sec. Parkinson’s Disease and Aging-related Movement Disorders Volume 14 - 2022 | https://doi.org/10.3389/fnagi.2022.1094914

Immunomodulatory effects of extracellular vesicles in glioblastoma Open

Johannes Jun Wei Low, Siti Aishah Sulaiman, Nor Adzimah Johdi, Nadiah Abu · 2022

Glioblastoma (GB) is a type of brain cancer that can be considered aggressive. Glioblastoma treatment has significant challenges due to the immune privilege site of the brain and the presentation of an immunosuppressive tumor microenvironm…

COVID-19 in Malaysia: exposure assessment and prevention practices among healthcare workers at a teaching hospital Open

Nor Azila Muhammad Azami, Nor Azian Abdul Murad, Azmawati Mohammed Nawi, Sharifah Azura Salleh, Petrick Periyasamy , et al. · 2021

Introduction: During the second wave of the coronavirus disease 19 (COVID-19) pandemic, Malaysia reported several COVID-19 clusters related to healthcare workers. Thus, addressing and understanding the risk of exposure in healthcare worker…

Nonalcoholic Fatty Liver Disease (NAFLD): Pathogenesis and Noninvasive Diagnosis Open

Vicneswarry Dorairaj, Siti Aishah Sulaiman, Nadiah Abu, Nor Azian Abdul Murad · 2021

The global prevalence of nonalcoholic fatty liver disease (NAFLD) or metabolic associated fatty liver disease (MAFLD), as it is now known, has gradually increased. NAFLD is a disease with a spectrum of stages ranging from simple fatty live…

The Role of Oxidative Stress in Suicidal Behaviour Among Bipolar Patients: A Cross-Sectional Study in a Malaysian Sample Open

Jiann Lin Loo, Nurul Ain Mohamad Kamal, Jo Aan Goon, Hanafi Ahmad Damanhuri, Jaclyn Ai Chin Tan , et al. · 2021

Background: Oxidative stress markers are found to be linked with depression and suicide attempts in bipolar disorder (BD), although the role of DNA damage as a marker of suicidal ideation and attempt has yet to be determined. We aim to inv…

Noncoding RNAs Interactions in Hepatic Stellate Cells during Hepatic Fibrosis Open

Siti Aishah Sulaiman, Vicneswarry Dorairaj, Khairun Nur Abdul Ghafar, Nor Azian Abdul Murad · 2021

Hepatic fibrosis is a reversible wound healing process following liver injury. Although this process is necessary for maintaining liver integrity, severe excessive extracellular matrix accumulation (ECM) could lead to permanent scar format…

ANALYSIS OF BLOOD LNCRNA EXPRESSION PROFILES IN TYPE 2 DIABETES INDIVIDUALS WITH DYSLIPIDEMIA Open

Siti Aishah Sulaiman, Nurruzanna Ismail, Vicneswarry Dorairaj, Nor Azian Abdul Murad · 2021

INTRODUCTION Long noncoding RNAs (lncRNAs) are large RNA transcripts present in the blood without protein-coding capacity, with specific expression profiles for type 2 diabetes (T2D) and other conditions such as dyslipidemia (DLP). The obj…

Long Non-Coding RNAs (lncRNAs) in Cardiovascular Disease Complication of Type 2 Diabetes Open

Nurruzanna Ismail, Noraidatulakma Abdullah, Nor Azian Abdul Murad, Rahman Jamal, Siti Aishah Sulaiman · 2021

The discovery of non-coding RNAs (ncRNAs) has opened a new paradigm to use ncRNAs as biomarkers to detect disease progression. Long non-coding RNAs (lncRNA) have garnered the most attention due to their specific cell-origin and their exist…

Extracellular Vesicles in the Development of the Non-Alcoholic Fatty Liver Disease: An Update Open

Vicneswarry Dorairaj, Siti Aishah Sulaiman, Nadiah Abu, Nor Azian Abdul Murad · 2020

Non-alcoholic fatty liver disease (NAFLD) is a broad spectrum of liver damage disease from a simple fatty liver (steatosis) to more severe liver conditions such as non-alcoholic steatohepatitis (NASH), fibrosis, and cirrhosis. Extracellula…

Interactions Among Non-Coding RNAs in Diabetic Nephropathy Open

Tamil Selvi Loganathan, Siti Aishah Sulaiman, Nor Azian Abdul Murad, Shamsul Azhar Shah, Abdul Halim Abdul Gafor , et al. · 2020

Diabetic Nephropathy (DN) is the most common cause of End-stage renal disease (ESRD). Although various treatments and diagnosis applications are available, DN remains a clinical and economic burden. Recent findings showed that noncoding RN…

Advancement in the diagnosis of mitochondrial diseases Open

Siti Aishah Sulaiman, Zamzureena Mohd Rani, Fara Zela Mohd Radin, Nor Azian Abdul Murad · 2020

Mitochondrial diseases are multi-systemic, heterogeneous groups of diseases that are associated with various neuromuscular problems, cardiovascular disorders, metabolic syndrome, cancer, and obesity. Mitochondrial diseases are due to mutat…

Regulatory Non-coding RNAs Network in Non-alcoholic Fatty Liver Disease Open

Siti Aishah Sulaiman, Nor I A Muhsin, Rahman Jamal · 2019

Non-alcoholic fatty liver disease (NAFLD) spectrum comprises simple steatosis and non-alcoholic steatohepatitis (NASH) that can lead to fibrosis and cirrhosis. The patients usually have no history of excessive alcohol consumption and other…

MUTATIONAL PROFILES OF F8 AND F9 IN A COHORT OF HAEMOPHILIA A AND HAEMOPHILIA B PATIENTS IN THE MULTI-ETHNIC MALAYSIAN POPULATION Open

Maimiza Zahari, Siti Aishah Sulaiman, Zulhabri Othman, Yasmin Ayob, Faraizah Abd Karim , et al. · 2018

Background: Haemophilia A (HA) and Haemophilia B (HB) are X-linked blood disorders that are caused by various mutations in the factor VIII (F8) and factor IX (F9) genes respectively. Identification of mutations is essential as some of the …

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