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View article: Beyond the Pelvis: Brain Metastases in Cervical Cancer – A Case Series from a Low-Middle-Income Country
Beyond the Pelvis: Brain Metastases in Cervical Cancer – A Case Series from a Low-Middle-Income Country Open
Brain metastases from cervical cancer are exceedingly rare and pose significant clinical challenges, particularly in low- and middle-income countries (LMICs), where access to advanced diagnostics and therapies may be limited. We report two…
View article: Elevated Body Mass Index as a Predictor of Cervical Cancer and Precancerous Lesions
Elevated Body Mass Index as a Predictor of Cervical Cancer and Precancerous Lesions Open
BACKGROUND Cervical cancer (CC) is the fourth most frequent cancer and fourth leading cause of death in women. In 2020, 604 000 new cases and 342 000 deaths worldwide were estimated. According to the Global Cancer Observatory, the incidenc…
View article: Changes in Neutrophil-to-Lymphocyte Ratio (NLR) in patients with low-grade Squamous Intraepithelial Lesions after Coriolus versicolor vaginal gel intervention
Changes in Neutrophil-to-Lymphocyte Ratio (NLR) in patients with low-grade Squamous Intraepithelial Lesions after Coriolus versicolor vaginal gel intervention Open
The aim of this study was to assess changes in NLR during intervention with Coriolus versicolor vaginal gel in patients with low-grade cervical precancerous lesions and to identify factors that influence the systemic inflammatory response.…
View article: Efficacy and Safety of Neoadjuvant Chemotherapy Plus Concurrent Chemoradiotherapy Compared to Concurrent Chemoradiotherapy Alone in Locally Advanced Cervical Cancer: A Systematic Review and Meta-Analysis
Efficacy and Safety of Neoadjuvant Chemotherapy Plus Concurrent Chemoradiotherapy Compared to Concurrent Chemoradiotherapy Alone in Locally Advanced Cervical Cancer: A Systematic Review and Meta-Analysis Open
In patients with locally advanced cervical cancer, NACT followed by CCRT is associated with comparable survival outcomes and a similar safety profile to standard CCRT, with a non-significant trend toward improved CR.
View article: Comparison of Chondroitin Sulfate-E Expression in Benign and Malignant Epithelial Type Ovarian Tumors
Comparison of Chondroitin Sulfate-E Expression in Benign and Malignant Epithelial Type Ovarian Tumors Open
Objective: Ovarian cancer is the fifth leading cause of cancer-related death in women, due to late diagnosis and limited screening methods. Chondroitin Sulfate-E (CS-E) has shown potential as biomarkers. This study aims to evaluate CS-E ex…
View article: HALP and SII: Innovative Biomarkers for Diagnosing Ovarian Cancer in Both Epithelial and Non-Epithelial Subtypes
HALP and SII: Innovative Biomarkers for Diagnosing Ovarian Cancer in Both Epithelial and Non-Epithelial Subtypes Open
Objective: To evaluate the diagnostic utility of PHAL (Platelet, Hemoglobin, Albumin, and Lymphocyte), SII (Systemic Immune Inflammation Index), and SIRI (Systemic Inflammatory Response Index) for both epithelial and non-epithelial ovarian…
View article: Management paradigm for ovarian neuroendocrine carcinoma: a systematic review
Management paradigm for ovarian neuroendocrine carcinoma: a systematic review Open
Introduction Neuroendocrine neoplasms (NENs) of the female genital tract are rare, comprising only 1–2% of gynecologic tumors, with ovarian neuroendocrine carcinoma (O-NEC) accounting for less than 1% of all ovarian cancers. Despite its ra…
View article: Comparative efficacy and safety of vaginal brachytherapy versus combined pelvic external beam radiotherapy and vaginal brachytherapy in managing intermediate to high-risk endometrial cancer: a systematic review and meta-analysis
Comparative efficacy and safety of vaginal brachytherapy versus combined pelvic external beam radiotherapy and vaginal brachytherapy in managing intermediate to high-risk endometrial cancer: a systematic review and meta-analysis Open
Purpose This review assesses the efficacy and safety of EBRT + VBT versus VBT alone in intermediate- to high-risk endometrial cancer. Methods A systematic review and meta-analysis were conducted using PubMed, EMBASE, ProQuest, Ovid, and Sc…
View article: Free syphilis screening, yet no cure: the gap in managing maternal syphilis in resource-limited primary care
Free syphilis screening, yet no cure: the gap in managing maternal syphilis in resource-limited primary care Open
Introduction: Syphilis, caused by Treponema pallidum, remains a significant global health challenge, with 660,000 congenital cases in 2016, causing 200,000 stillbirths. In Indonesia, free syphilis rapid diagnostic tests (RDTs) are integrat…
View article: Systemic Inflammatory Biomarkers as a Predictive Markers for Ovarian Cancer
Systemic Inflammatory Biomarkers as a Predictive Markers for Ovarian Cancer Open
Systemic inflammatory biomarkers, particularly SII may aid in the predictive markers of early ovarian with diagnostic values nearly as good as CA125 (sensitivity 71.64% vs 75.97%). These biomarkers can serve as complementary predictive mar…
View article: Effectiveness and Efficiency Comparison of One-Day vs Eight-Day Methotrexate Protocols in Managing Low-Risk Gestational Trophoblastic Neoplasia
Effectiveness and Efficiency Comparison of One-Day vs Eight-Day Methotrexate Protocols in Managing Low-Risk Gestational Trophoblastic Neoplasia Open
The 1-day MTX 300 mg/m² protocol is as an effective treatment option for low-risk GTN compared to the 8-day MTX 50 mg protocol.
View article: The Relationship between Maternal Characteristics and Neonatal Outcomes of Premature Rupture of Membranes
The Relationship between Maternal Characteristics and Neonatal Outcomes of Premature Rupture of Membranes Open
Introduction: Premature rupture of the membranes occurs when the amniotic membrane bursts before 37 weeks of gestation. Preterm labour is the primary cause of perinatal and neonatal death, with premature membrane rupture accounting for 40%…
View article: Nomogram development for predicting ovarian tumor malignancy using inflammatory biomarker and CA-125
Nomogram development for predicting ovarian tumor malignancy using inflammatory biomarker and CA-125 Open
Global challenges in ovarian cancer underscore the need for cost-effective screening. This study aims to assess the role of pretreatment Neutrophil-to-Lymphocyte Ratio (NLR), Lymphocyte-to-Monocyte-Ratio (LMR), Platelet-to-Lymphocyte Ratio…
View article: Allogeneic human umbilical cord mesenchymal stem cell secretome effect on apoptosis of HeLa cells
Allogeneic human umbilical cord mesenchymal stem cell secretome effect on apoptosis of HeLa cells Open
Introduction: Cervical cancer treatment typically involves surgery, chemotherapy, and radiotherapy. However, exploring novel treatment approaches is crucial. Stem cell secretome therapy provides new insights as an additional option in the …
View article: #659 HPV vaccine as a gender neutral vaccine in jakarta, indonesia: parental knowledge and adherence
#659 HPV vaccine as a gender neutral vaccine in jakarta, indonesia: parental knowledge and adherence Open
Introduction/Background Introduction: Human papillomavirus (HPV) infection causes a variety of malignancies in both men and women. Cervical cancer is the fourth most frequent disease in women worldwide, while being one of the most preventa…
View article: Comparison of glutaminase and cancer antigen 125 for distinguishing benign and malignant ovarian tumors
Comparison of glutaminase and cancer antigen 125 for distinguishing benign and malignant ovarian tumors Open
Increasing demand for glutaminase (GLS) due to high rates of glutamine metabolism is considered one of the hallmarks of malignancy. In parallel, cancer antigen 125 (CA‐125) is a commonly used ovarian tumor marker. This study aimed to compa…
View article: Recurrent Partial Hydatidiform Mole: A Case Report of Seven Consecutive Molar Pregnancies
Recurrent Partial Hydatidiform Mole: A Case Report of Seven Consecutive Molar Pregnancies Open
Hydatidiform mole (HM) is an aberrant pregnancy characterized by atypical trophoblastic hyperplasia, hydropic chorionic villi, and deprived fetal development. There are two types of HM, ie, complete (CHM) and partial (PHM). Both CHM and PH…
View article: Clinical and Management Dilemmas Concerning Early-Stage Cervical Cancer in Pregnancy – A Case Report
Clinical and Management Dilemmas Concerning Early-Stage Cervical Cancer in Pregnancy – A Case Report Open
Cancer diagnosis during pregnancy adversely impacts women's physical and psychological states. Symptoms may mimic pregnancy-related conditions, thus delaying diagnosis. Its management involves a multidisciplinary team to protect both mater…
View article: Relationship Between D-Dimer Levels and Neutrophil-to-Lymphocyte Ratio (NLR) in Preeclamptic Pregnant Women with COVID-19: A Cohort Study
Relationship Between D-Dimer Levels and Neutrophil-to-Lymphocyte Ratio (NLR) in Preeclamptic Pregnant Women with COVID-19: A Cohort Study Open
BACKGROUND Preeclampsia involves an inflammatory response and vascular endothelial dysfunction. In COVID-19, there is also tissue damage and an inflammatory response that stimulates the formation of D-dimers and an increase in the neutroph…
View article: Association of HPV Genotyping with HIF1-Alpha in Advanced Cervical Cancer on Response to Radiotherapy
Association of HPV Genotyping with HIF1-Alpha in Advanced Cervical Cancer on Response to Radiotherapy Open
AIM: This study aims to determine the relationship between the HPV genotype in uterine cervical cancer and the expression of HIF-1α due to tissue hypoxia and its impact on radiation response. METHODS: This study is an analytic and observat…
View article: The Presence of Ascites and Irregular Tumor Surface as Strong Predictors for Ovarian Malignancy
The Presence of Ascites and Irregular Tumor Surface as Strong Predictors for Ovarian Malignancy Open
BACKGROUND: Ovarian cancer is the most dangerous gynecologic cancer and one of the top five causes of cancer death in women. One of the intraoperative strategies to diagnose and manage women with ovarian cancer is by doing intraoperative f…
View article: Comparison Levels of Copper, Zinc, and Cu/Zn Ratio of in Pre-eclampsia and Normal Pregnancy
Comparison Levels of Copper, Zinc, and Cu/Zn Ratio of in Pre-eclampsia and Normal Pregnancy Open
Introduction Preeclampsia is a syndrome that occurs in pregnancy, characterized by hypertension, proteinuria and edema. Zinc and copper are micronutrients that play a role in the performance of several important enzymes in the human body, …