Siwei Mao
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View article: Integrated analysis identifies CD276 in fibroblasts as a malignancy predictor and regulator of neutrophil infiltration in hepatoblastoma
Integrated analysis identifies CD276 in fibroblasts as a malignancy predictor and regulator of neutrophil infiltration in hepatoblastoma Open
Background: Hepatoblastoma is the most prevalent liver cancer in children. Immunotherapy targeting immune checkpoint molecules has become pivotal in various cancer treatments. However, the clinical significance of immune checkpoint ligands…
View article: Malignant Hepatoblast‐Like Cells Sustain Stemness via IGF2‐Dependent Cholesterol Accumulation in Hepatoblastoma
Malignant Hepatoblast‐Like Cells Sustain Stemness via IGF2‐Dependent Cholesterol Accumulation in Hepatoblastoma Open
Hepatoblastoma, the most aggressive childhood liver tumor, poses significant challenges due to limited knowledge of its pathogenesis, particularly in poorly differentiated advanced tumors where the prognosis is dismal. Single‐cell sequenci…
O-GlcNAcylation of glutaminase isoform KGA inhibits ferroptosis through activation of glutaminolysis in hepatoblastoma Open
Hepatoblastoma (HB), the most common pediatric hepatic malignancy, exhibits an increasing incidence. Metabolism reprogramming represents a pivotal hallmark in the oncogenic transformation process, with glutamine emerging as a critical ener…
Supplementary Figure S2 from Causal Relationship between Sex Hormone-Binding Globulin and Risk of Neuroblastoma: A Bidirectional Two-Sample Mendelian Randomization Study Open
Supplementary Figure S2 shows the Manhattan plot of the SNPs associated with female SHBG levels.
Supplementary Figure S1 from Causal Relationship between Sex Hormone-Binding Globulin and Risk of Neuroblastoma: A Bidirectional Two-Sample Mendelian Randomization Study Open
Supplementary Figure S1 shows the Manhattan plot of the SNPs associated with male SHBG levels.
Supplementary Table S2 from Causal Relationship between Sex Hormone-Binding Globulin and Risk of Neuroblastoma: A Bidirectional Two-Sample Mendelian Randomization Study Open
Supplementary Table S2 shows the LDtrait result of SNPs when employing female SHBG as exposure and NB as outcome.
Supplementary Figure S2 from Causal Relationship between Sex Hormone-Binding Globulin and Risk of Neuroblastoma: A Bidirectional Two-Sample Mendelian Randomization Study Open
Supplementary Figure S2 shows the Manhattan plot of the SNPs associated with female SHBG levels.
Supplementary Table S4 from Causal Relationship between Sex Hormone-Binding Globulin and Risk of Neuroblastoma: A Bidirectional Two-Sample Mendelian Randomization Study Open
Supplementary Table S4 shows the LDtrait result of SNPs when employing NB as exposure and female SHBG as outcome.
Supplementary Table S3 from Causal Relationship between Sex Hormone-Binding Globulin and Risk of Neuroblastoma: A Bidirectional Two-Sample Mendelian Randomization Study Open
Supplementary Table S3 shows the LDtrait result of SNPs when employing NB as exposure and male SHBG as outcome.
Supplementary Table S4 from Causal Relationship between Sex Hormone-Binding Globulin and Risk of Neuroblastoma: A Bidirectional Two-Sample Mendelian Randomization Study Open
Supplementary Table S4 shows the LDtrait result of SNPs when employing NB as exposure and female SHBG as outcome.
Supplementary Table S2 from Causal Relationship between Sex Hormone-Binding Globulin and Risk of Neuroblastoma: A Bidirectional Two-Sample Mendelian Randomization Study Open
Supplementary Table S2 shows the LDtrait result of SNPs when employing female SHBG as exposure and NB as outcome.
Supplementary Table S3 from Causal Relationship between Sex Hormone-Binding Globulin and Risk of Neuroblastoma: A Bidirectional Two-Sample Mendelian Randomization Study Open
Supplementary Table S3 shows the LDtrait result of SNPs when employing NB as exposure and male SHBG as outcome.
Data from Causal Relationship between Sex Hormone-Binding Globulin and Risk of Neuroblastoma: A Bidirectional Two-Sample Mendelian Randomization Study Open
Background:The causal relationship between sex hormone-binding globulin (SHBG) and neuroblastoma remains unknown. This study aimed to explore the causality between SHBG and the risk of neuroblastoma using bidirectional two-sample Mendelian…
Data from Causal Relationship between Sex Hormone-Binding Globulin and Risk of Neuroblastoma: A Bidirectional Two-Sample Mendelian Randomization Study Open
Background:The causal relationship between sex hormone-binding globulin (SHBG) and neuroblastoma remains unknown. This study aimed to explore the causality between SHBG and the risk of neuroblastoma using bidirectional two-sample Mendelian…
Supplementary Figure S1 from Causal Relationship between Sex Hormone-Binding Globulin and Risk of Neuroblastoma: A Bidirectional Two-Sample Mendelian Randomization Study Open
Supplementary Figure S1 shows the Manhattan plot of the SNPs associated with male SHBG levels.
Supplementary Table S1 from Causal Relationship between Sex Hormone-Binding Globulin and Risk of Neuroblastoma: A Bidirectional Two-Sample Mendelian Randomization Study Open
Supplementary Table S1 shows the LDtrait result of SNPs when employing male SHBG as exposure and NB as outcome.
Supplementary Table S1 from Causal Relationship between Sex Hormone-Binding Globulin and Risk of Neuroblastoma: A Bidirectional Two-Sample Mendelian Randomization Study Open
Supplementary Table S1 shows the LDtrait result of SNPs when employing male SHBG as exposure and NB as outcome.
N6-methyladenosine modification of LATS2 promotes hepatoblastoma progression by inhibiting ferroptosis through the YAP1/ATF4/PSAT1 axis Open
Ferroptosis has attracted extensive interest from cancer researchers due to its substantial potential as a therapeutic target. The role of LATS2, a core component of the Hippo pathway cascade, in ferroptosis initiation in hepatoblastoma (H…
View article: Anti-ferroptotic PRKAA2 serves as a potential diagnostic and prognostic marker for hepatoblastoma
Anti-ferroptotic PRKAA2 serves as a potential diagnostic and prognostic marker for hepatoblastoma Open
PRKAA2 functions as a tumor-promoting factor in HB by promoting cell proliferation and prohibiting ferroptosis. Ferroptosis-related genes PRKAA2 is a potential diagnostic and prognostic marker for HB as well as a novel therapeutic target i…
<i>O</i>‐GlcNAcylated LARP1 positively regulated by circCLNS1A facilitates hepatoblastoma progression through DKK4/β‐catenin signalling Open
Background Accumulating studies have shown that La‐related protein 1 (LARP1) is involved in the occurrence and development of various tumours. However, the expression pattern and biological role of LARP1 in hepatoblastoma (HB) remain uncle…
Phase separation of YAP mediated by coiled‐coil domain promotes hepatoblastoma proliferation via activation of transcription Open
Aim and Background Yes‐associated protein (YAP), a key transcriptional co‐activator associated with cell fate and tumor progression, has been reported to be a powerful driver of hepatoblastoma (HB). In this study, we investigated the mecha…
View article: SNORD11B-mediated 2′-O-methylation of primary let-7a in colorectal carcinogenesis
SNORD11B-mediated 2′-O-methylation of primary let-7a in colorectal carcinogenesis Open
Evidence indicates that small nucleolar RNAs (snoRNAs) participate in tumorigenesis and development and could be promising biomarkers for colorectal cancer (CRC). Here, we examine the profile of snoRNAs in CRC and find that expression of S…
SNORA14A inhibits hepatoblastoma cell proliferation by regulating SDHB-mediated succinate metabolism Open
Hepatoblastoma (HB) is the most common paediatric liver malignancy. Dysregulation of small nucleolar RNAs (snoRNAs) is a critical inducer of tumour initiation and progression. However, the association between snoRNAs and HB remains unknown…
IL‐27 improves adoptive CD8<sup>+</sup> T cells’ antitumor activity via enhancing cell survival and memory T cell differentiation Open
IL‐27 is an anti‐inflammatory cytokine that triggers enhanced antitumor immunity, particularly cytotoxic T lymphocyte responses. In the present study, we sought to develop IL‐27 into a therapeutic adjutant for adoptive T cell therapy using…
HBprem: A database of transcription, translation, and posttranscriptional and posttranslational modifications in hepatoblastoma Open
Dear Editor, Hepatoblastoma (HB), the most common type primary malignant embryonal hepatic tumor, is usually diagnosed in pediatric patients during the first 3 years of life, which accounts for 60-85% of all hepatic tumors in children.1 Th…