Sixian Wu
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View article: Integrated subcellular localization of functional fluorescence probes and functional analysis in motile spermatozoa by an AI-enhanced algorithm
Integrated subcellular localization of functional fluorescence probes and functional analysis in motile spermatozoa by an AI-enhanced algorithm Open
In the evaluation of male infertility, precise assessment of sperm functional competence has surpassed the requirements of conventional semen parameters. Existing computer-aided analysis systems are deficient at the molecular diagnostic le…
View article: Distinct germ-line genetic mutation patterns correlate with reproductive outcomes in ICSI patients: a pilot study
Distinct germ-line genetic mutation patterns correlate with reproductive outcomes in ICSI patients: a pilot study Open
Background Infertility affects approximately 15% of couples worldwide, with male factors accounting for nearly 50% of cases. Intracytoplasmic sperm injection (ICSI) has become the standard treatment for male factor infertility, but outcome…
View article: CEP112 coordinates translational regulation of essential fertility genes during spermiogenesis through phase separation in humans and mice
CEP112 coordinates translational regulation of essential fertility genes during spermiogenesis through phase separation in humans and mice Open
Spermiogenesis, the complex transformation of haploid spermatids into mature spermatozoa, relies on precise spatiotemporal regulation of gene expression at the post-transcriptional level. The mechanisms underlying this critical process rem…
View article: Novel PLCZ1 compound heterozygous mutations indicate gene dosage effect involved in total fertilisation failure after ICSI
Novel PLCZ1 compound heterozygous mutations indicate gene dosage effect involved in total fertilisation failure after ICSI Open
In brief PLCZ1 mutations are related to total fertilisation failure (TFF) after intracytoplasmic sperm injection (ICSI), characterised by abnormal oocyte oscillations. The novel PLCZ1 compound heterozygous mutations reported by this study …
View article: Clinical and molecular characteristics of <i>RNF43</i> mutations as promising prognostic biomarkers in colorectal cancer
Clinical and molecular characteristics of <i>RNF43</i> mutations as promising prognostic biomarkers in colorectal cancer Open
Background: Transmembrane E3 ubiquitin ligase ( RNF43) mutations are present in approximately 6–18% of colorectal cancers (CRC) and could enhance Wnt/β-catenin signaling, which is emerging as a promising therapeutic target. This study aims…
View article: Dissecting Sperm Mitochondrial G-Quadruplex Structures Using a Fluorescent Probe Biomarker to Monitor and Regulate Fertilization Capability
Dissecting Sperm Mitochondrial G-Quadruplex Structures Using a Fluorescent Probe Biomarker to Monitor and Regulate Fertilization Capability Open
To monitor the levels of mitochondrial DNA G-quadruplexes (mtDNA G4s) in spermatozoa and to explore the possibility using mtDNA G4s as a reliable marker in patients with multiple clinical insemination failures, a novel chemical TPE-mTO pro…
View article: State-of-art technologies to detect the DNA damage and repair in sperm and future outlook
State-of-art technologies to detect the DNA damage and repair in sperm and future outlook Open
View article: Revelation of Β-Galactosidase Variation in Senile Sperms and Organs Via a Silicon Xanthene Near-Infrared Probe
Revelation of Β-Galactosidase Variation in Senile Sperms and Organs Via a Silicon Xanthene Near-Infrared Probe Open
View article: A novel missense mutation in GREB1L identified in a three-generation family with renal hypodysplasia/aplasia-3
A novel missense mutation in GREB1L identified in a three-generation family with renal hypodysplasia/aplasia-3 Open
View article: Developing rat testicular organoid models for assessing the reproductive toxicity of antidepression drugs &lt;italic&gt;in vitro&lt;/italic&gt;
Developing rat testicular organoid models for assessing the reproductive toxicity of antidepression drugs <italic>in vitro</italic> Open
With the increasing incidence of depression worldwide, antidepressant medications are commonly used in males of reproductive age for long-term treatment of depression, as well as other disorders. Antidepressants are known to be associated …
View article: Monitoring tumour resistance to the BRAF inhibitor combination regimen in colorectal cancer patients via circulating tumour DNA
Monitoring tumour resistance to the BRAF inhibitor combination regimen in colorectal cancer patients via circulating tumour DNA Open
Analysis of ctDNA can provide novel insights into molecular resistance mechanisms to VIC in BRAFV600E mCRC patients, allowing accurate guidance for clinicians in personalised treatment strategies.
View article: The novel BRDT inhibitor NHWD870 shows potential as a male contraceptive in mice
The novel BRDT inhibitor NHWD870 shows potential as a male contraceptive in mice Open
Small molecule inhibitors of the bromodomain and extraterminal domain (BET) family proteins have emerged as promising options not only for the treatment of multiple cancers but also for disturbing the process of sperm maturation with poten…
View article: A loss-of-function variant in SSFA2 causes male infertility with globozoospermia and failed oocyte activation
A loss-of-function variant in SSFA2 causes male infertility with globozoospermia and failed oocyte activation Open
Globozoospermia (OMIM: 102530) is a rare type of teratozoospermia (< 0.1%). The etiology of globozoospermia is complicated and has not been fully revealed. Here, we report an infertile patient with globozoospermia. Variational analysis rev…
View article: A novel missense variant in the CASK gene causes intellectual developmental disorder and microcephaly with pontine and cerebellar hypoplasia
A novel missense variant in the CASK gene causes intellectual developmental disorder and microcephaly with pontine and cerebellar hypoplasia Open
View article: Deficiency of X-linked TENT5D causes male infertility by disrupting the mRNA stability during spermatogenesis
Deficiency of X-linked TENT5D causes male infertility by disrupting the mRNA stability during spermatogenesis Open
View article: An Update on the Relationship of SARS-CoV-2 and Male Reproduction
An Update on the Relationship of SARS-CoV-2 and Male Reproduction Open
Since the outbreak of the COVID-19, up to now, infection cases have been continuously rising to over 200 million around the world. Male bias in morbidity and mortality has emerged in the COVID-19 pandemic. The infection of SARS-CoV-2 has b…
View article: Expression and Correlation of IgG4 and IL-21 in Collagen-Induced Arthritis Rats
Expression and Correlation of IgG4 and IL-21 in Collagen-Induced Arthritis Rats Open
IL-21 may promote the occurrence and development of rheumatoid arthritis by combining with IL-21r to regulate the content of IgG4.
View article: Spermidine Inhibits Joints Inflammation and Macrophage Activation in Mice with Collagen-Induced Arthritis
Spermidine Inhibits Joints Inflammation and Macrophage Activation in Mice with Collagen-Induced Arthritis Open
These results suggest that SPD may protect CIA mice by inhibiting the polarization of M1 macrophages in the synovial tissue, reducing pro-inflammatory cytokines, and promoting anti-inflammatory factor release.
View article: Clinical characteristics and laboratory features of COVID-19 in high altitude areas: A retrospective cohort study
Clinical characteristics and laboratory features of COVID-19 in high altitude areas: A retrospective cohort study Open
Coronavirus disease 2019 (COVID-19) is highly contagious and has affected the whole world. We seek to investigate the clinical and laboratory characteristics of COVID-19 patients in the high altitude areas of Sichuan, China. In this retros…
View article: A Novel Loss-of-function Pathogenic Missense Mutation in CASK Gene Causes Mental Retardation and Microcephaly with Pontine and Cerebellar Hypoplasia
A Novel Loss-of-function Pathogenic Missense Mutation in CASK Gene Causes Mental Retardation and Microcephaly with Pontine and Cerebellar Hypoplasia Open
Background: Mutations in the CASK gene result in a wide range of observed phenotypes in humans like FG Syndrome 4 and mental retardation. In this study, researchers investigated the case of an 11-month-old female diagnosed with mental reta…
View article: Recent Advances on Drugs and Vaccines for COVID-19
Recent Advances on Drugs and Vaccines for COVID-19 Open
The current situation of Coronavirus Disease 2019 (COVID-19) worldwide is still very severe. Presently, many breakthroughs have been accomplished in the research and development of drugs for the treatment of COVID-19, especially vaccines; …
View article: Clinical characteristics and laboratory features of COVID-19 in high altitude areas: A retrospective cohort study
Clinical characteristics and laboratory features of COVID-19 in high altitude areas: A retrospective cohort study Open
Background: Coronavirus disease 2019 (COVID-19) is highly contagious and has affected the whole world. We aim to investigate the clinical and laboratory characteristics of COVID-19 patients in high altitude areas of Sichuan, China. Methods…
View article: Withdrawn: Lipid nanoparticles co-loaded with miRNA-22 and methotrexate for enhanced anti-inflammatory response in rheumatoid arthritis
Withdrawn: Lipid nanoparticles co-loaded with miRNA-22 and methotrexate for enhanced anti-inflammatory response in rheumatoid arthritis Open
The Accepted Manuscript version of this article (published on 18 August 2020) was withdrawn on 3 December 2020 due to concerns over data validity.
View article: [Thromboelastography-based assessment of coagulation function in patients with chronic kidney disease and the risk factors of hypercoagulability].
[Thromboelastography-based assessment of coagulation function in patients with chronic kidney disease and the risk factors of hypercoagulability]. Open
s The hypercoagulable state of patients with CKD worsens gradually with the disease progression, and eGFR, platelet count and hemoglobin levels are all risk factors for the hypercoagulable state in patients with CKD.
View article: Author response for "Tobramycin suppresses HUWE1 degradation to control MCL‐1 stability during tumour development"
Author response for "Tobramycin suppresses HUWE1 degradation to control MCL‐1 stability during tumour development" Open
View article: ETA-mediated anti-TNF-α therapy ameliorates the phenotype of PCOS model induced by letrozole
ETA-mediated anti-TNF-α therapy ameliorates the phenotype of PCOS model induced by letrozole Open
Chronic inflammation is a typical characteristic of polycystic ovary syndrome (PCOS), in which, tumor necrosis factor (TNF)-α plays an important role. We investigated whether anti-TNF-α therapy can alleviate the core phenotypes of PCOS. In…