Shibao Lu
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View article: Efficacy of acupuncture for generalized anxiety disorder: a systematic review
Efficacy of acupuncture for generalized anxiety disorder: a systematic review Open
The protocol of the review was registered in PROSPERO (CRD42015016033).
View article: Role and mechanism of METTL3 in fibrosis-associated signaling in CVB3-infected H9c2 cardiomyocytes through the lncRNA MEG3/c-MYC/SMAD2 axis
Role and mechanism of METTL3 in fibrosis-associated signaling in CVB3-infected H9c2 cardiomyocytes through the lncRNA MEG3/c-MYC/SMAD2 axis Open
Viral myocarditis (VMC) is an inflammatory disease of the heart muscle caused by viral infection and may lead to myocardial fibrosis. This study aims to investigate the role of METTL3 in myocardial fibrosis in VMC. METTL3 expression was in…
View article: Higher Improvement in Oswestry Disability Index Is Appropriate to Increase Satisfaction of Frail Patients After Lumbar Fusion Surgery
Higher Improvement in Oswestry Disability Index Is Appropriate to Increase Satisfaction of Frail Patients After Lumbar Fusion Surgery Open
Frail patients with lower preoperative ODI were significantly more likely to experience postoperative satisfaction, whereas nonfrail/prefrail patients with higher preoperative ODI were significantly more likely to experience postoperative …
View article: Machine learning approaches for predicting prolonged hospital length of stay after lumbar fusion surgery in patients aged 75 years and older: a retrospective cohort study based on comprehensive geriatric assessment
Machine learning approaches for predicting prolonged hospital length of stay after lumbar fusion surgery in patients aged 75 years and older: a retrospective cohort study based on comprehensive geriatric assessment Open
OBJECTIVE Postoperative recovery following lumbar fusion surgery in patients aged 75 years and older often requires a prolonged length of stay (PLOS) in the hospital. Accurately predicting the risk of PLOS and assessing its risk factors fo…
View article: Fetal Sylvian Fissure Charts to Evaluate the Development of Fetal Brain using Prenatal MRI
Fetal Sylvian Fissure Charts to Evaluate the Development of Fetal Brain using Prenatal MRI Open
Objective: To explore the normal developmental pattern of the sylvian fissure (SF) in fetuses by MRI for better identifying cortical abnormalities in the early stage by quantifying the morphological characteristics. Methods: This study ret…
View article: Sex-specific characteristics of the trunk muscle behaviors in an asymptomatic adult cohort
Sex-specific characteristics of the trunk muscle behaviors in an asymptomatic adult cohort Open
We created a database concerning the isometric and isokinetic trunk torques in an asymptomatic adult cohort. The results could be provided as physiological references in the future for comparison between subjects with and without trunk mus…
View article: [Digital three-dimensional assisted unilateral biportal endoscopy in treatment of highly isolated lumbar disc herniation with translaminar approach].
[Digital three-dimensional assisted unilateral biportal endoscopy in treatment of highly isolated lumbar disc herniation with translaminar approach]. Open
UBE via translaminar approach is safe and effective for the treatment of highly isolated LDH, which is beneficial to protect the facet joint, maintain spinal stability, and reduce soft tissue injury. With the assistance of digital 3D techn…
View article: Machine-learning models for the prediction of ideal surgical outcomes in patients with adult spinal deformity
Machine-learning models for the prediction of ideal surgical outcomes in patients with adult spinal deformity Open
Aims Adult spinal deformity (ASD) surgery can reduce pain and disability. However, the actual surgical efficacy of ASD in doing so is far from desirable, with frequent complications and limited improvement in quality of life. The accurate …
View article: Machine Learning-based Cluster Analysis Identifies Three Unique Phenotypes of Patients With Adult Spinal Deformity With Distinct Clinical Profiles and Long-term Recovery Trajectory
Machine Learning-based Cluster Analysis Identifies Three Unique Phenotypes of Patients With Adult Spinal Deformity With Distinct Clinical Profiles and Long-term Recovery Trajectory Open
Study Design. A retrospective review of a prospective adult spinal deformity data. Objective. To identify distinct patient clinical profiles and recovery trajectories in patients with adult spinal deformity (ASD). Summary of Background Dat…
View article: Enhanced recovery pathway in adult patients with spinal deformity undergoing open thoracolumbar surgery
Enhanced recovery pathway in adult patients with spinal deformity undergoing open thoracolumbar surgery Open
According to the results of our study, it is necessary to implement an ERAS protocol for adult patients with spinal deformity undergoing long-segment fusion surgery. The ERAS protocol is effective in reducing postoperative hospital length …
View article: Trunk muscle behaviors during the full-cycle stoop and squat lifting tasks
Trunk muscle behaviors during the full-cycle stoop and squat lifting tasks Open
Background Lifting is generally considered as a risk factor for low back pain. A thorough investigation of the muscle function during lifting is essential for a better assessment of the potential risk of muscle impairment and towards impro…
View article: Two-stage surgery with oblique lateral interbody fusion and posterior fixation in degenerative scoliosis with lumbosacral curve-driven degenerative lumbar scoliosis: a feasible option to prevent postoperative coronal decompensation
Two-stage surgery with oblique lateral interbody fusion and posterior fixation in degenerative scoliosis with lumbosacral curve-driven degenerative lumbar scoliosis: a feasible option to prevent postoperative coronal decompensation Open
For type 2 DLS, two-stage surgery of OLIF with posterior fixation represents a more efficient surgical approach, reducing surgical fusion segments, causing less trauma and bleeding, and effectively avoiding postoperative coronal plane deco…
View article: Preoperative Nutritional Status Screened by MNA-SF Predicts Major Complications in Elderly Patients Undergoing Lumbar Fusion Surgery
Preoperative Nutritional Status Screened by MNA-SF Predicts Major Complications in Elderly Patients Undergoing Lumbar Fusion Surgery Open
Preoperative nutritional risk or malnutrition is an independent risk factor for major complications among older patients undergoing posterior lumbar fusion surgery. The MNS-SF emerges as a convenient and effective tool for promptly screeni…
View article: Risk Factors Analysis and Nomogram Conduction for Major Adverse Events After Lumbar Fusion Surgery in Older Patients: A Prospective Cohort Study
Risk Factors Analysis and Nomogram Conduction for Major Adverse Events After Lumbar Fusion Surgery in Older Patients: A Prospective Cohort Study Open
Preoperative frailty, hypoalbuminemia, female sex, greater body mass index, and higher Charlson comorbidity index grade were risk factors for 90-day major AEs after lumbar fusion surgery in older patients. The predictive nomogram that we d…
View article: Analysis of factors influencing the surgical treatment outcomes of spinal injuries in polytrauma patients
Analysis of factors influencing the surgical treatment outcomes of spinal injuries in polytrauma patients Open
Background: This study aims to analyze the diagnosis and treatment conditions of polytrauma patients with spinal injuries, to clarify the site of the first surgical intervention, the timing of the surgery, and factors influencing prognosis…
View article: Increased neutrophil extracellular traps caused by diet‐induced obesity delay fracture healing
Increased neutrophil extracellular traps caused by diet‐induced obesity delay fracture healing Open
Obesity, recognized as a risk factor for nonunion, detrimentally impacts bone health, with significant physical and economic repercussions for affected individuals. Nevertheless, the precise pathomechanisms by which obesity impairs fractur…
View article: Trehalose Rescues Postmenopausal Osteoporosis Induced by Ovariectomy through Alleviating Osteoblast Pyroptosis via Promoting Autophagy
Trehalose Rescues Postmenopausal Osteoporosis Induced by Ovariectomy through Alleviating Osteoblast Pyroptosis via Promoting Autophagy Open
Background: Osteoporosis, a prevalent bone metabolic disease, often requires long-term drug treatments that may lead to serious side effects. Trehalose, a natural disaccharide found in various organisms, has been shown to have a promoting …
View article: Evaluation and analysis of risk factors for adverse events of the fractured vertebra post-percutaneous kyphoplasty: a retrospective cohort study using multiple machine learning models
Evaluation and analysis of risk factors for adverse events of the fractured vertebra post-percutaneous kyphoplasty: a retrospective cohort study using multiple machine learning models Open
Four independent risk factors were identified of AEFV, and five risk prediction models that can aid clinicians in the accurate identification of high-risk patients and prediction of the occurrence of AEFV were developed.
View article: How does cervical sagittal profile change after the spontaneous compensation of global sagittal imbalance following one- or two-level lumbar fusion
How does cervical sagittal profile change after the spontaneous compensation of global sagittal imbalance following one- or two-level lumbar fusion Open
Purpose This study aimed to evaluate the cervical sagittal profile after the spontaneous compensation of global sagittal imbalance and analyze the associations between the changes in cervical sagittal alignment and spinopelvic parameters. …
View article: Single-cell RNA sequencing unveils the activation of EGR1-ATF3 signaling in EGR1 + muscle stem cells during human paravertebral muscle degeneration
Single-cell RNA sequencing unveils the activation of EGR1-ATF3 signaling in EGR1 + muscle stem cells during human paravertebral muscle degeneration Open
Background: Paravertebral muscles (PVM) degeneration (PMD) is closely associated with low back pain. Muscle stem cells (MuSCs) can promote muscle regeneration and repair. However, our understanding of the cellular composition of PVM and th…
View article: Change of cervical flexion range of motion influences postoperative sagittal alignment of the cervical spine after laminoplasty
Change of cervical flexion range of motion influences postoperative sagittal alignment of the cervical spine after laminoplasty Open
Objective The relationships between preoperative cervical spine range of motion (ROM) and postoperative cervical sagittal alignment (CSA), and clinical outcomes after laminoplasty (LMP) have been widely studied. However, the impact of ROM …