Siyang Zhang
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View article: Identification and validation of lactate-related gene signatures in endometriosis for clinical evaluation and immune characterization by WGCNA and machine learning
Identification and validation of lactate-related gene signatures in endometriosis for clinical evaluation and immune characterization by WGCNA and machine learning Open
Background Endometriosis is a common benign gynecologic disease in women of reproductive age, and its manifestations remarkably decrease quality of life. Lactate, as a metabolite, exerts prominent effects across a wide range of biological …
View article: Shenyuan granules improve cellular senescence through Klotho-mediated p16/p21 signaling pathway in diabetic kidney disease
Shenyuan granules improve cellular senescence through Klotho-mediated p16/p21 signaling pathway in diabetic kidney disease Open
Context Shenyuan Granules (SYG), a traditional Chinese medicine preparation, are clinically used for treating chronic kidney diseases. However, the role of Klotho in modulating cellular senescence via the p16/p21 pathway and its involvemen…
View article: VideoMerge: Towards Training-free Long Video Generation
VideoMerge: Towards Training-free Long Video Generation Open
Long video generation remains a challenging and compelling topic in computer vision. Diffusion based models, among the various approaches to video generation, have achieved state of the art quality with their iterative denoising procedures…
View article: Optimizing Spectral Properties of Cesium Tungsten Bronze Films Doped with Silver Nanowires Based on the Machine Learning Method
Optimizing Spectral Properties of Cesium Tungsten Bronze Films Doped with Silver Nanowires Based on the Machine Learning Method Open
View article: Comparative characterization and correlation between lipids and volatile organic compounds in NingXiang and Berkshire-Ningxiang pork
Comparative characterization and correlation between lipids and volatile organic compounds in NingXiang and Berkshire-Ningxiang pork Open
Lipids and volatile organic compounds (VOCs) are essential contributors to meat flavor. However, no studies to date have comprehensively explored the lipids and VOCs in raw pork from Ningxiang (NX) pigs and their hybrid breed Berkshire × N…
View article: Identification of crucial modules and genes associated with backfat tissue development by WGCNA in Ningxiang pigs
Identification of crucial modules and genes associated with backfat tissue development by WGCNA in Ningxiang pigs Open
Fat deposition is an economically important trait in pigs. Ningxiang pig, one of the four famous indigenous breeds in China, is characterized by high fat content. The underlying gene expression pattern in different developmental periods of…
View article: Retraction Note: SNHG6 modulates oxidized low-density lipoprotein-induced endothelial cells injury through miR-135a-5p/ROCK in atherosclerosis
Retraction Note: SNHG6 modulates oxidized low-density lipoprotein-induced endothelial cells injury through miR-135a-5p/ROCK in atherosclerosis Open
View article: RGS1 and related genes as potential targets for immunotherapy in cervical cancer: computational biology and experimental validation
RGS1 and related genes as potential targets for immunotherapy in cervical cancer: computational biology and experimental validation Open
View article: Circ_0000231 Promotes Paclitaxel Resistance in Ovarian Cancer by Regulating miR-140/RAP1B
Circ_0000231 Promotes Paclitaxel Resistance in Ovarian Cancer by Regulating miR-140/RAP1B Open
Purpose: Circular RNAs (circRNAs) are identified as vital regulators in a variety of cancers. However, the involvement of circ_0000231 in paclitaxel (PTX) resistant ovarian cancer (OC) remains unclear. Methods: The levels of circ_0000231, …
View article: PRPF6 promotes metastasis and paclitaxel resistance of ovarian cancer via SNHG16/CEBPB/GATA3 axis
PRPF6 promotes metastasis and paclitaxel resistance of ovarian cancer via SNHG16/CEBPB/GATA3 axis Open
Background: Metastasis and paclitaxel (PTX) resistance are the main reason for the poor prognosis of ovarian cancer (OC). Evidence has shown that RNA-binding proteins (RBPs) and long noncoding RNAs (lncRNAs) can modulate post-transcription…
View article: Nocardia rubra cell‐wall skeleton influences the development of cervical carcinoma by promoting the antitumor effect of macrophages and dendritic cells
Nocardia rubra cell‐wall skeleton influences the development of cervical carcinoma by promoting the antitumor effect of macrophages and dendritic cells Open
Background As an immune enhancer, Nocardia rubra cell‐wall skeleton (Nr‐CWS) has been used to treat persistent human papillomavirus infection and cervical precancerous lesions. However, it is still unclear whether it can be used to treat c…
View article: PRPF6 Induces the Alternative Splicing of lncRNA SNHG16 To Promote Progression and Paclitaxel Resistance of Ovarian Cancer via Regulating GATA3 Transcription
PRPF6 Induces the Alternative Splicing of lncRNA SNHG16 To Promote Progression and Paclitaxel Resistance of Ovarian Cancer via Regulating GATA3 Transcription Open
Background Small nucleolar RNA host gene 16 (SNHG16) and pre-mRNA processing factor 6(PRPF6) play vital roles in regulatory mechanisms of multiple cancers, but the mechanisms in ovarian cancer (OC) remains poorly understood. Methods The ex…
View article: CircGNG4 Promotes the Progression of Prostate Cancer by Sponging miR-223 to Enhance EYA3/c-myc Expression
CircGNG4 Promotes the Progression of Prostate Cancer by Sponging miR-223 to Enhance EYA3/c-myc Expression Open
Patients diagnosed with prostate cancer often have a poor prognosis and limited treatment options, as the specific pathogenesis remains to be elucidated. Circular RNA (circRNA) is a type of non-coding RNA that interacts with microRNA (miRN…
View article: MicroRNA‑219a‑2‑3p modulates the proliferation of thyroid cancer cells via the HPSE/cyclin D1 pathway
MicroRNA‑219a‑2‑3p modulates the proliferation of thyroid cancer cells via the HPSE/cyclin D1 pathway Open
Heparanase (HPSE) is an endo-β-D-glucuronidase overexpressed in different types of human cancer, and a predicted target of microRNA (miRNA/miR)-219a-2-3p in thyroid cancer. The present study aimed to investigate the potential role of HPSE …
View article: RETRACTED ARTICLE: SNHG6 modulates oxidized low-density lipoprotein-induced endothelial cells injury through miR-135a-5p/ROCK in atherosclerosis
RETRACTED ARTICLE: SNHG6 modulates oxidized low-density lipoprotein-induced endothelial cells injury through miR-135a-5p/ROCK in atherosclerosis Open
View article: CBLL1 is highly expressed in non‐small cell lung cancer and promotes cell proliferation and invasion
CBLL1 is highly expressed in non‐small cell lung cancer and promotes cell proliferation and invasion Open
Background Studies have shown that E3 ubiquitin ligase CBLL1 plays multiple roles in development and tumorigenesis. CBLL1 is over‐expressed in colon cancer and associated with cancer cell proliferation. While, the overexpression of CBLL1 i…
View article: DRAM2 acts as an oncogene in non-small cell lung cancer and suppresses the expression of p53
DRAM2 acts as an oncogene in non-small cell lung cancer and suppresses the expression of p53 Open
View article: Origin of dolomite in the Middle Ordovician peritidal platform carbonates in the northern Ordos Basin, western China
Origin of dolomite in the Middle Ordovician peritidal platform carbonates in the northern Ordos Basin, western China Open
The carbonates in the Middle Ordovician Ma 5 5 submember of the Majiagou Formation in the northern Ordos Basin are partially to completely dolomitized. Two types of replacive dolomite are distinguished: (1) type 1 dolomite, which is primar…
View article: More expression of BDNF associates with lung squamous cell carcinoma and is critical to the proliferation and invasion of lung cancer cells
More expression of BDNF associates with lung squamous cell carcinoma and is critical to the proliferation and invasion of lung cancer cells Open
Our data show that BDNF probably facilitates the tumorigenesis of lung SCC and ADC. The expression of BDNF mRNA variant IX is probably more helpful to the upregulation of BDNF in SCC, and intervening the production of BDNF could be a possi…