Explanipedia

Nonstructural Protein 1 Mediates HMGB1 Release by Targeting Histone H1.0 After Respiratory Syncytial Virus Infection In Vivo and In Vitro Open

Na Zhou, Siyi Che, Hui Zhai, Xiaohong Xie, Enmei Liu , et al. · 2025

High mobility group box-1 (HMGB1) is implicated in airway inflammation during the late phase of respiratory syncytial virus (RSV) infection. Despite its recognized role, the specific mechanism underlying its release post-RSV infection rema…

SIRT1: potential target in glucocorticoid-resistant diseases Open

Jun Xie, Siyi Che, Jiao Liu, Xiaoru Long · 2025

Glucocorticoid resistance is a challenging problem in clinical practice. Increasing glucocorticoid sensitivity and reducing resistance are important in the management of certain diseases. In steroid-resistant airway inflammatory diseases, …

An unusual cause of cardiac arrest in a young infant Open

Yuhao Wu, Siyi Che, Yonggang Li · 2024

Andrographolide sulfonate downregulation of TLR3-TRIF and amelioration of airway inflammation caused by respiratory syncytial virus infection Open

Na Zhou, Siyi Che, Jiao Liu, Zhenghong Jiang, Luo Ren , et al. · 2024

Intranasal Andro-S inhibits RSV replication and ameliorates RSV infection-induced lung inflammation by downregulating TLR3 and TRIF. Therefore, intranasal administration may be a suitable drug delivery method for treating RSV infection.

Cardiac arrest and myocardial calcification in a child Open

Yonggang Li, Yue Tang, Siyi Che, Yuhao Wu · 2024

Single-cell transcriptome reveals highly complement activated microglia cells in association with pediatric tuberculous meningitis Open

Siwei Mo, Chenyan Shi, Yi Cai, Maozhu Xu, Hongmei Xu , et al. · 2024

Background Tuberculous meningitis (TBM) is a devastating form of tuberculosis (TB) causing high mortality and disability. TBM arises due to immune dysregulation, but the underlying immune mechanisms are unclear. Methods We performed single…

Extensive and Progressive Cerebral Infarction Associated with Mycoplasma pneumoniae Infection. A Case Report and Literature Review Open

Shijia Ni, Siyi Che, Jinhua Cai · 2024

Mycoplasma pneumoniae (MP) is one of the most common respiratory pathogens causing respiratory infection in children, especially in those above 5 years old. Although rare, cerebral infarction is the most severe neurological complication of…

Extensive and Progressive Cerebral Infarction Associated with Mycoplasma pneumoniae Infection. A Case Report and Literature Review Open

Shijia Ni, Siyi Che, Jinhua Cai · 2024

BackgroundsMycoplasma pneumoniae (MP) is one of the most common respiratory pathogens causing respiratory infection in children, especially in those above 5 years old. Although rare, cerebral infarction is the most severe neurological comp…

Traditional Chinese medicine andrographolide sulfonate alleviates airway inflammation by supressing TRL3-TRIF in mice post respiratory syncytial virus infection Open

Na Zhou, Siyi Che, Luo Ren, Shiyi Chen, Yin Liu , et al. · 2023

Background Andrographolide sulfonate is a proprietary Traditional Chinese Medicine used for the treatment of childhood respiratory tract infections. However, its effective role in respiratory syncytial virus (RSV) infection remain unclear.…

Polystyrene nanoplastics lead to ferroptosis in the lungs Open

Yuhao Wu, Junke Wang, Tianxin Zhao, Mang Sun, Maozhu Xu , et al. · 2023

Andrographolide exerts anti-respiratory syncytial virus activity by up-regulating heme oxygenase-1 independent of interferon responses in human airway epithelial cells Open

Siyi Che, Na Zhou, Ying Liu, Jun Xie, Enmei Liu · 2023

Andrographolide exerts anti-respiratory syncytial virus activity by up-regulating heme oxygenase-1 independent of interferon responses in human airway epithelial cells Open

Siyi Che, Na Zhou, Ying Liu, Jun Xie, Enmei Liu · 2022

Background: Respiratory syncytial virus (RSV), the leading cause of mortality and morbidity in children under the age of five, is still lacking in safe and effective vaccines and antiviral agents for clinical use. Andrographolide exerts an…

Andrographolide attenuates RSV-induced inflammation by suppressing apoptosis and promoting pyroptosis after respiratory syncytial virus infection in vitro Open

Siyi Che, Xiaohong Xie, Jilei Lin, Ying Liu, Jun Xie , et al. · 2022

Respiratory syncytial virus (RSV), the most common viral pathogen causing acute lower respiratory tract infection among children under five years old worldwide, still lacks specific therapeutic drugs. Andrographolide has been found efficac…

Breastfeeding of infants born to mothers with COVID-19: a rapid review Open

Nan Yang, Siyi Che, Jingyi Zhang, Xia Wang, Yuyi Tang , et al. · 2020

The current evidence indicates that SARS-CoV-2 viral nucleic acid has not been detected in breast milk. The benefits of breastfeeding may outweigh the risk of SARS-CoV-2 infection in infants. Mothers with COVID-19 should take appropriate p…

Breastfeeding of Infants Born to Mothers with COVID-19: A Rapid Review Open

Nan Yang, Siyi Che, Jingyi Zhang, Xia Wang, Yuyi Tang , et al. · 2020

Background Existing recommendations on whether mothers with COVID-19 should continue breastfeeding are still conflicting. We aimed to conduct a rapid review of mother-to-child transmission of COVID-19 during breastfeeding. Methods We syste…

[Clinical effect of azithromycin adjuvant therapy in children with bronchiolitis: a systematic review and Meta analysis]. Open

Siyi Che, Huan He, Yu Deng, Enmei Liu · 2019

AZM adjuvant therapy can reduce the time to the relief of wheezing and cough in children with bronchiolitis, but it has no marked effect on the length of hospital stay and oxygen supply time.

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