Shuguang Wei
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View article: Astrocytic PCBP1 Suppresses Ferroptosis to Restore Glutamatergic Homeostasis and Mitigate Stress‐Induced Depression in Male Mice
Astrocytic PCBP1 Suppresses Ferroptosis to Restore Glutamatergic Homeostasis and Mitigate Stress‐Induced Depression in Male Mice Open
Major depressive disorder (MDD) is a critical psychiatric illness with significant societal implications. The exact molecular mechanisms underlying MDD, specifically concerning cellular iron metabolism and ferroptosis, remain inadequately …
View article: Identification of BET inhibitors (BETi) against solitary fibrous tumor (SFT) through high-throughput screening (HTS)
Identification of BET inhibitors (BETi) against solitary fibrous tumor (SFT) through high-throughput screening (HTS) Open
Cancers, especially fusion oncoprotein (FO)-driven hematological cancers and sarcomas, often develop from a low number of key mutations. Solitary Fibrous Tumor (SFT) is a rare mesenchymal tumor driven by the NAB2-STAT6 oncofusion gene. Cur…
View article: The effectiveness of mindfulness-based cognitive therapy on rumination and related psychological indicators: a systematic review and meta-analysis
The effectiveness of mindfulness-based cognitive therapy on rumination and related psychological indicators: a systematic review and meta-analysis Open
The present findings confirm the feasibility of MBCT in diminishing rumination and enhancing related psychological indicators. Furthermore, these effects were sustained throughout the follow-up period.
View article: Preparation and Optimization of Mn2+-Activated Na2ZnGeO4 Phosphors: Insights into Precursor Selection and Microwave-Assisted Solid-State Synthesis
Preparation and Optimization of Mn2+-Activated Na2ZnGeO4 Phosphors: Insights into Precursor Selection and Microwave-Assisted Solid-State Synthesis Open
Mn2+-doped phosphors emitting green light have garnered significant interest due to their potential applications in display technologies and solid-state lighting. To facilitate the rapid synthesis of high-performance Mn2+-activated green p…
View article: Bombyx mori Jun gene is involved in endoreplication of silk gland cells by regulating S-phase cell cycle genes
Bombyx mori Jun gene is involved in endoreplication of silk gland cells by regulating S-phase cell cycle genes Open
Endoreplication as a variant of the cell cycle is an important avenue of development and reproduction for organisms. Endoreplication-induced polyploid cells are pivotal in ensuring the normal size and function of tissues and organs. Howeve…
View article: Drug resistance and genetic transmission characteristics of HIV-1 CRF55_01B in people living with HIV/AIDS (PLWHA) in Henan Province, China
Drug resistance and genetic transmission characteristics of HIV-1 CRF55_01B in people living with HIV/AIDS (PLWHA) in Henan Province, China Open
Background Among the many CRFs, CRF55_01B was the first CRF01_AE and subtype B recombinant strain identified around 2013 among men who have sex with men (MSM) in Shenzhen, China. With rapid spreading throughout the country, CRF55_01B has a…
View article: HIV-1 subtype distribution and drug resistance profiles among PLWHA with detectable viremia in Henan Province, China, 2023
HIV-1 subtype distribution and drug resistance profiles among PLWHA with detectable viremia in Henan Province, China, 2023 Open
In China, Henan Province is a region with a high HIV burden. Furthermore, drug resistance (DR) among people living with HIV/AIDS (PLWHA) on antiretroviral therapy (ART) is becoming a critical barrier to achieving viral suppression. Monitor…
View article: Identification of BET Inhibitors (BETi) Against Solitary Fibrous Tumor (SFT) Through High-Throughput Screening (HTS)
Identification of BET Inhibitors (BETi) Against Solitary Fibrous Tumor (SFT) Through High-Throughput Screening (HTS) Open
Cancers, especially fusion oncoprotein (FO)-driven hematological cancers and sarcomas, often develop from a low number of key mutations. Solitary Fibrous Tumor (SFT) is a rare mesenchymal tumor driven by the NAB2-STAT6 oncofusion gene. Cur…
View article: Lightweight Lung-nodule Detection Model Combined with Multidimensional Attention Convolution
Lightweight Lung-nodule Detection Model Combined with Multidimensional Attention Convolution Open
Background: Early and timely detection of pulmonary nodules and initiation treatment can substantially improve the survival rate of lung carcinoma. However, current detection methods based on convolutional neural networks (CNNs) cannot eas…
View article: High-efficiency 14-plex cSNP SNaPshot assay for peripheral blood identification and specific mRNA polymorphic analysis
High-efficiency 14-plex cSNP SNaPshot assay for peripheral blood identification and specific mRNA polymorphic analysis Open
View article: A Causality-Informed and Copula-based Framework for Predictive Assessment of Downstream Water-Quality Risks under Extreme Scenarios
A Causality-Informed and Copula-based Framework for Predictive Assessment of Downstream Water-Quality Risks under Extreme Scenarios Open
View article: Identification of Methamphetamine Abusers Can Be Supported by EEG-Based Wavelet Transform and BiLSTM Networks
Identification of Methamphetamine Abusers Can Be Supported by EEG-Based Wavelet Transform and BiLSTM Networks Open
View article: Characteristics of drug resistance mutations in ART-experienced HIV-1 patients with low-level viremia in Zhengzhou City, China
Characteristics of drug resistance mutations in ART-experienced HIV-1 patients with low-level viremia in Zhengzhou City, China Open
Although most people living with HIV (PLWH) receiving antiretroviral therapy (ART) achieve continuous viral suppression, some show detectable HIV RNA as low-level viremia (LLV) (50–999 copies/mL). Drug resistance mutations (DRMs) in PLWH w…
View article: Deep Learning Algorithms for Sports Data Analysis and Prediction in Sports Competitions
Deep Learning Algorithms for Sports Data Analysis and Prediction in Sports Competitions Open
Sports data analysis and prediction are essential for gaining a competitive advantage in today’s sports. Artificial Neural Networks (ANNs) have shown promising outcomes in several disciplines, including sports analytics. Sports data is dyn…
View article: Consistency of drug-resistant mutations in plasma and peripheral blood mononuclear cells of patients with treatment-naïve and treatment-experienced HIV-1 infection
Consistency of drug-resistant mutations in plasma and peripheral blood mononuclear cells of patients with treatment-naïve and treatment-experienced HIV-1 infection Open
Introduction Genotypic drug resistance testing is cursrently recommended by the World Health Organization for all patients infected with human immunodeficiency virus type 1 (HIV-1) undergoing care or switching regimes due to failure with p…
View article: IDR-targeting compounds suppress HPV genome replication via disruption of phospho-BRD4 association with DNA damage response factors
IDR-targeting compounds suppress HPV genome replication via disruption of phospho-BRD4 association with DNA damage response factors Open
View article: Sensitivity Analysis of a Double-Layer Coupling Structure for an Electric Vehicle Wireless Power Transfer System
Sensitivity Analysis of a Double-Layer Coupling Structure for an Electric Vehicle Wireless Power Transfer System Open
This paper proposes a novel coupling structure wireless power transfer (WPT) technology for improving the charging and recharging efficiency between electric vehicles (EVs) in the case that the transmitting and receiving coils are not exac…
View article: Drug resistance mutations among people living with HIV with treatment failure in Henan Province, China
Drug resistance mutations among people living with HIV with treatment failure in Henan Province, China Open
To the Editor: Drug resistance mutations (DRMs) involving human deficiency virus type 1 (HIV-1) diminish the efficacy of current antiretroviral therapy (ART) regimens, resulting in treatment failure. A better understanding of the prevalenc…
View article: Increased prevalence of pretreatment drug resistance mutations in treatment-naïve people living with HIV-1 in Henan Province, China (2022/23)
Increased prevalence of pretreatment drug resistance mutations in treatment-naïve people living with HIV-1 in Henan Province, China (2022/23) Open
Human deficiency virus type 1 (HIV-1) harboring drug resistance mutations (DRMs) before the initiation of antiretroviral therapy (ART) poses a serious threat to the efficacy of current ART regimens. Currently, the prevalence of pre-treatme…
View article: Kappa opioid receptor in nucleus accumbens regulates depressive-like behaviors following prolonged morphine withdrawal in mice
Kappa opioid receptor in nucleus accumbens regulates depressive-like behaviors following prolonged morphine withdrawal in mice Open
Prolonged withdrawal from opioids leads to negative emotions. Kappa opioid receptor (KOR) plays an important role in opioid addiction and affective disorders. However, the underlying mechanism of KOR in withdrawal-related depression is sti…
View article: Small molecule glucagon release inhibitors with activity in human islets
Small molecule glucagon release inhibitors with activity in human islets Open
Purpose Type 1 diabetes (T1D) accounts for an estimated 5% of all diabetes in the United States, afflicting over 1.25 million individuals. Maintaining long-term blood glucose control is the major goal for individuals with T1D. In T1D, insu…
View article: Glucocorticoid mediated inhibition of LKB1 mutant non-small cell lung cancers
Glucocorticoid mediated inhibition of LKB1 mutant non-small cell lung cancers Open
The glucocorticoid receptor (GR) is an important anti-cancer target in lymphoid cancers but has been understudied in solid tumors like lung cancer, although glucocorticoids are often given with chemotherapy regimens to mitigate side effect…
View article: Review on Key Technologies and Development of Magnetic Coupling Resonant-Dynamic Wireless Power Transfer for Unmanned Ground Vehicles
Review on Key Technologies and Development of Magnetic Coupling Resonant-Dynamic Wireless Power Transfer for Unmanned Ground Vehicles Open
With the fast development of magnetic coupling resonant-dynamic wireless power transfer (MCR-DWPT), it is more likely that high-efficiency wireless charging between unmanned ground vehicles (UGVs) will be practically realized, especially i…
View article: The strategies of exercise intervention for adolescent depression: A meta-analysis of randomized controlled trials
The strategies of exercise intervention for adolescent depression: A meta-analysis of randomized controlled trials Open
Purpose This study aimed to investigate the effect of exercise intervention, and analyze exercise intervention strategies for adolescent depression through a meta-analysis of RCTs. Methods Accordance to PRISMA guidelines, PubMed, Medline, …
View article: Identification of a Class of WNK Isoform-Specific Inhibitors Through High-Throughput Screening
Identification of a Class of WNK Isoform-Specific Inhibitors Through High-Throughput Screening Open
The newly discovered classes of compounds may be starting points for generating pharmacological tools and potential drugs treating hypertension and cancer.
View article: High-throughput functional annotation of natural products by integrated activity profiling
High-throughput functional annotation of natural products by integrated activity profiling Open
Determining mechanism of action (MOA) is one of the biggest challenges in natural products discovery. Here, we report a comprehensive platform that uses Similarity Network Fusion (SNF) to improve MOA predictions by integrating data from th…
View article: Prevalence of transmitted drug resistance mutations among patients infected with human immunodeficiency virus type 1 (HIV-1) in Henan Province, China
Prevalence of transmitted drug resistance mutations among patients infected with human immunodeficiency virus type 1 (HIV-1) in Henan Province, China Open
To the Editor: Even with the emergence of highly active antiretroviral therapy, human immunodeficiency virus type 1 (HIV-1) remains a serious public health problem worldwide. The widespread use of antiretroviral therapy (ART) has, on the o…
View article: The nuclear factor E2-related factor 2 participates in morphine-induced autophagy
The nuclear factor E2-related factor 2 participates in morphine-induced autophagy Open
Morphine is an important potent analgesic which has many side effects such as addiction. Studies have demonstrated that autophagy play an important role during morphine addiction especially in morphine withdrawal. However, the molecular ba…
View article: Targeting ESR1 mutation–induced transcriptional addiction in breast cancer with BET inhibition
Targeting ESR1 mutation–induced transcriptional addiction in breast cancer with BET inhibition Open
Acquired mutations in the ligand-binding domain (LBD) of the gene encoding estrogen receptor α (ESR1) are common mechanisms of endocrine therapy resistance in patients with metastatic ER+ breast cancer. The ESR1 Y537S mutation, in particul…
View article: The structure of importin α and the nuclear localization peptide of ChREBP, and small compound inhibitors of ChREBP–importin α interactions
The structure of importin α and the nuclear localization peptide of ChREBP, and small compound inhibitors of ChREBP–importin α interactions Open
The carbohydrate response element binding protein (ChREBP) is a glucose-responsive transcription factor that plays a critical role in glucose-mediated induction of genes involved in hepatic glycolysis and lipogenesis. In response to fluctu…