Siyoung Kim
YOU?
Author Swipe
View article: Mechanism for oil-phase separation by the lipid droplet assembly complex
Mechanism for oil-phase separation by the lipid droplet assembly complex Open
Summary Cells store metabolic energy as triglyceride (TG) oils in lipid droplets (LDs). LDs form de novo from the endoplasmic reticulum. How the lipid droplet assembly complex (LDAC), composed of seipin and LDAF1 1,2 , catalyzes the organi…
View article: MSBack: Multiscale Backmapping of Highly Coarse-grained Proteins Using Constrained Diffusion
MSBack: Multiscale Backmapping of Highly Coarse-grained Proteins Using Constrained Diffusion Open
Coarse-grained (CG)molecular dynamics is a powerful tool for simulating the collective behavior of biomolecules. However, the structural information lost during coarse-graining prevents the CG configurations from being more widely useful (…
View article: Generation of hypoimmunogenic universal iPS cells through HLA-type gene knockout
Generation of hypoimmunogenic universal iPS cells through HLA-type gene knockout Open
Hypoimmunogenic universal induced pluripotent stemn (iPS) cells were generated through the targeted disruption of key genes, including human leukocyte antigen ( HLA )- A , HLA-B and HLA-DR alpha ( DRA ), using the CRISPR–Cas9 system. This …
View article: Correction to “Computational Studies of Lipid Droplets”
Correction to “Computational Studies of Lipid Droplets” Open
ADVERTISEMENT RETURN TO ARTICLES ASAPPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to "Computational Studies of Lipid Droplets"Siyoung KimSiyoung KimMore by Siyoung Kim, Jessica M. J. Swanson*Jessica M. J…
View article: Backmapping with Mapping and Isomeric Information
Backmapping with Mapping and Isomeric Information Open
I present a powerful and flexible backmapping tool named Multiscale Simulation Tool ( mstool ) that converts a coarse-grained (CG) system into all-atom (AA) resolution and only requires AA to CG mapping and isomeric information ( cis/trans…
View article: Data from Carbonyl Reductase 1 Offers a Novel Therapeutic Target to Enhance Leukemia Treatment by Arsenic Trioxide
Data from Carbonyl Reductase 1 Offers a Novel Therapeutic Target to Enhance Leukemia Treatment by Arsenic Trioxide Open
Arsenic trioxide (As2O3) is used, in current practice, as an effective chemotherapeutic agent for acute promyelocytic leukemia (APL). However, the side effects and relatively low efficacy of As2O3 in treating other leukemias have limited i…
View article: Supplementary Methods from Carbonyl Reductase 1 Offers a Novel Therapeutic Target to Enhance Leukemia Treatment by Arsenic Trioxide
Supplementary Methods from Carbonyl Reductase 1 Offers a Novel Therapeutic Target to Enhance Leukemia Treatment by Arsenic Trioxide Open
PDF file - 169K
View article: Effects of Exhaustive Exercise on Inflammatory, Apoptotic, and Antioxidative Signaling Pathways in Human Peripheral Blood Mononuclear Cells
Effects of Exhaustive Exercise on Inflammatory, Apoptotic, and Antioxidative Signaling Pathways in Human Peripheral Blood Mononuclear Cells Open
In the present study, we investigated the effects of exhaustive exercise and recovery on inflammatory, pro-apoptotic, and anti-oxidative responses in human peripheral blood mononuclear cells (PBMCs). Sixteen volunteers participated in a gu…
View article: Data from Carbonyl Reductase 1 Offers a Novel Therapeutic Target to Enhance Leukemia Treatment by Arsenic Trioxide
Data from Carbonyl Reductase 1 Offers a Novel Therapeutic Target to Enhance Leukemia Treatment by Arsenic Trioxide Open
Arsenic trioxide (As2O3) is used, in current practice, as an effective chemotherapeutic agent for acute promyelocytic leukemia (APL). However, the side effects and relatively low efficacy of As2O3 in treating other leukemias have limited i…
View article: Supplementary Methods from Carbonyl Reductase 1 Offers a Novel Therapeutic Target to Enhance Leukemia Treatment by Arsenic Trioxide
Supplementary Methods from Carbonyl Reductase 1 Offers a Novel Therapeutic Target to Enhance Leukemia Treatment by Arsenic Trioxide Open
PDF file - 169K
View article: A Phase II Trial of S-1 and Oxaliplatin in Patients with Metastatic Breast Cancer Previously Treated with Anthracycline and Taxane (KCSG-BR07-03)
A Phase II Trial of S-1 and Oxaliplatin in Patients with Metastatic Breast Cancer Previously Treated with Anthracycline and Taxane (KCSG-BR07-03) Open
Purpose This single-arm phase II trial investigate the efficacy and safety of S-1 plus oxaliplatin (SOX) in patients with metastatic breast cancer.Materials and Methods Patients with metastatic breast cancer previously treated with anthrac…
View article: The structure, catalytic mechanism, and inhibitor identification of phosphatidylinositol remodeling MBOAT7
The structure, catalytic mechanism, and inhibitor identification of phosphatidylinositol remodeling MBOAT7 Open
Cells remodel glycerophospholipid acyl chains via the Lands cycle to adjust membrane properties. Membrane-bound O -acyltransferase (MBOAT) 7 acylates lyso-phosphatidylinositol (lyso-PI) with arachidonyl-CoA. MBOAT7 mutations cause brain de…
View article: Seipin transmembrane segments critically function in triglyceride nucleation and lipid droplet budding from the membrane
Seipin transmembrane segments critically function in triglyceride nucleation and lipid droplet budding from the membrane Open
Lipid droplets (LDs) are organelles formed in the endoplasmic reticulum (ER) to store triacylglycerol (TG) and sterol esters. The ER protein seipin is key for LD biogenesis. Seipin forms a cage-like structure, with each seipin monomer cont…
View article: Author response: Seipin transmembrane segments critically function in triglyceride nucleation and lipid droplet budding from the membrane
Author response: Seipin transmembrane segments critically function in triglyceride nucleation and lipid droplet budding from the membrane Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Lipid droplets (LDs) a…
View article: Computational Studies of Lipid Droplets
Computational Studies of Lipid Droplets Open
Lipid droplets (LDs) are intracellular organelles whose primary function is energy storage. Known to emerge from the endoplasmic reticulum (ER) bilayer, LDs have a unique structure with a core consisting of neutral lipids, triacylglycerol …
View article: Key Factors Governing Initial Stages of Lipid Droplet Formation
Key Factors Governing Initial Stages of Lipid Droplet Formation Open
Lipid droplets (LDs) are neutral lipid storage organelles surrounded by a phospholipid (PL) monolayer. LD biogenesis from the endoplasmic reticulum is driven by phase separation of neutral lipids, overcoming surface tension and membrane de…
View article: Seipin transmembrane segments critically function in triglyceride nucleation and lipid droplet budding from the membrane
Seipin transmembrane segments critically function in triglyceride nucleation and lipid droplet budding from the membrane Open
Lipid droplets (LDs) are organelles formed in the endoplasmic reticulum (ER) to store triacylglycerol (TG) and sterol esters. The ER protein seipin is key for LD biogenesis. Seipin forms a cage-like structure, with each seipin monomer cont…
View article: Key Factors Governing Initial Stages of Lipid Droplet Formation
Key Factors Governing Initial Stages of Lipid Droplet Formation Open
Lipid droplets (LDs) are neutral lipid storage organelles surrounded by a phospholipid (PL) monolayer. LD biogenesis from the endoplasmic reticulum (ER) is driven by phase separation of neutral lipids, overcoming surface tension and membra…
View article: Physical Characterization of Triolein and Implications for Its Role in Lipid Droplet Biogenesis
Physical Characterization of Triolein and Implications for Its Role in Lipid Droplet Biogenesis Open
Lipid droplets (LDs) are neutral lipid-storing organelles surrounded by a phospholipid (PL) monolayer. At present, how LDs are formed in the endoplasmic reticulum (ER) bilayer is poorly understood. In this study, we present a revised all-a…
View article: Stressed Lipid Droplets: How Neutral Lipids Relieve Surface Tension and Membrane Expansion Drives Protein Association
Stressed Lipid Droplets: How Neutral Lipids Relieve Surface Tension and Membrane Expansion Drives Protein Association Open
Lipid droplets (LDs) are intracellular storage organelles composed of neutral lipids, such as triacylglycerol (TG), surrounded by a phospholipid (PL) monolayer decorated with specific proteins. Herein, we investigate the mechanism of prote…
View article: Physical Characterization of Triolein and Implications for Its Role in Lipid Droplet Biogenesis
Physical Characterization of Triolein and Implications for Its Role in Lipid Droplet Biogenesis Open
Lipid droplets (LDs) are neutral lipid storing organelles surrounded by a phospholipid (PL) monolayer. At present, how LDs are formed in the endoplasmic reticulum (ER) bilayer is poorly understood. In this study, we present a revised all-a…
View article: <scp>PyCDFT</scp>: A Python package for constrained density functional theory
<span>PyCDFT</span>: A Python package for constrained density functional theory Open
We present PyCDFT, a Python package to compute diabatic states using constrained density functional theory (CDFT). PyCDFT provides an object‐oriented, customizable implementation of CDFT, and allows for both single‐point self‐consistent‐fi…
View article: Methionine Enkephalin Suppresses Osteocyte Apoptosis Induced by Compressive Force through Regulation of Nuclear Translocation of <scp>NFATc1</scp>
Methionine Enkephalin Suppresses Osteocyte Apoptosis Induced by Compressive Force through Regulation of Nuclear Translocation of <span>NFATc1</span> Open
Mechanical stress stimulates bone remodeling, which occurs through bone formation and resorption, resulting in bone adaptation in response to the mechanical stress. Osteocytes perceive mechanical stress loaded to bones and promote bone rem…
View article: Acute myeloid leukemia with t(11;19)(q23;p13.1) in a patient with a gastrointestinal stromal tumor undergoing imatinib therapy: A case report
Acute myeloid leukemia with t(11;19)(q23;p13.1) in a patient with a gastrointestinal stromal tumor undergoing imatinib therapy: A case report Open
Physicians should consider the potential risks of developing hematologic malignancies, including therapy-related AML, in patients with GISTs receiving IM treatment.