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View article: Audiobook-CC: Controllable Long-context Speech Generation for Multicast Audiobook
Audiobook-CC: Controllable Long-context Speech Generation for Multicast Audiobook Open
Existing text-to-speech systems predominantly focus on single-sentence synthesis and lack adequate contextual modeling as well as fine-grained performance control capabilities for generating coherent multicast audiobooks. To address these …
View article: Stage-Specific Lipidomes of Gastrodia elata Extracellular Vesicles Modulate Fungal Symbiosis
Stage-Specific Lipidomes of Gastrodia elata Extracellular Vesicles Modulate Fungal Symbiosis Open
The mycoheterotrophic orchid Gastrodia elata relies entirely on symbiosis with Armillaria for nutrient acquisition during tuber development. The signaling mechanisms underlying this interaction have long been a research focus, and several …
View article: Evaluation of TaMFT-3A and TaMKK3-4A alleles on wheat pre-harvest sprouting
Evaluation of TaMFT-3A and TaMKK3-4A alleles on wheat pre-harvest sprouting Open
Pre‐harvest sprouting (PHS) is a significant challenge affecting global production of wheat ( Triticum aestivum L.). Resistance to PHS is governed by both genetic and environmental factors, making reliable molecular markers essential for e…
View article: Current status of generalized pustular psoriasis: Findings from a multicenter hospital-based survey of 127 Chinese patients
Current status of generalized pustular psoriasis: Findings from a multicenter hospital-based survey of 127 Chinese patients Open
Background: Generalized pustular psoriasis (GPP), a rare and recurrent autoinflammatory disease, imposes a substantial burden on patients and society. Awareness of GPP in China remains limited. Methods: This cross-sectional survey, conduct…
View article: Mining the Candidate Transcription Factors Modulating Tanshinones’ and Phenolic Acids’ Biosynthesis Under Low Nitrogen Stress in Salvia miltiorrhiza
Mining the Candidate Transcription Factors Modulating Tanshinones’ and Phenolic Acids’ Biosynthesis Under Low Nitrogen Stress in Salvia miltiorrhiza Open
Mining valuable genes is helpful to breed high-quality Salvia miltiorrhiza exhibiting efficient nitrogen fertilizer utilization efficiency. In the present study, transcriptome sequencing was introduced to select the candidate transcription…
View article: The Combination of Shading and Potassium Application Regulated the Bulb Active Ingredients Accumulation in Fritillaria thunbergii Miq. by Affecting Rhizosphere Microecology
The Combination of Shading and Potassium Application Regulated the Bulb Active Ingredients Accumulation in Fritillaria thunbergii Miq. by Affecting Rhizosphere Microecology Open
The bulbs of the lily plant Fritillaria thunbergii Miq. possess substantial medicinal properties for relieving coughs and clearing the lungs. However, excessive pursuit of yield during cultivation has led to a decrease in medicinal ingredi…
View article: ZEB1-AS1 as a TRPML1 Inhibitor to Cause Lysosome Dysfunction and Cardiac Damage in Aged Mice
ZEB1-AS1 as a TRPML1 Inhibitor to Cause Lysosome Dysfunction and Cardiac Damage in Aged Mice Open
The prevalence of cardiovascular diseases (CVDs) has increased markedly as the world population has aged. Long non-coding RNAs (lncRNAs) have been reported as novel regulators in diverse pathophysiological conditions. Here, we performed RN…
View article: GLO1 regulates hepatocellular carcinoma proliferation and migration through the cell cycle pathway
GLO1 regulates hepatocellular carcinoma proliferation and migration through the cell cycle pathway Open
GLO1 represents a promising therapeutic target for HCC, providing valuable insights into its role in the viability and proliferation of HCC cells.
View article: Recent Advancements and Trends of Topical Drug Delivery Systems in Psoriasis: A Review and Bibliometric Analysis
Recent Advancements and Trends of Topical Drug Delivery Systems in Psoriasis: A Review and Bibliometric Analysis Open
Psoriasis is an immune-mediated inflammatory skin disease where topical therapy is crucial. While various dosage forms have enhanced the efficacy of current treatments, their limited permeability and lack of targeted delivery to the dermis…
View article: Toll-like receptors 2 polymorphism is associated with psoriasis: A case-control study in the northern Chinese population
Toll-like receptors 2 polymorphism is associated with psoriasis: A case-control study in the northern Chinese population Open
Background Psoriasis is a disease caused by genetics and immune system dysfunction, affecting the skin and joints. Toll-like receptors (TLRs) play an important role in triggering the innate immune response and controlling adaptive immunity…
View article: SmEIL1 transcription factor inhibits tanshinone accumulation in response to ethylene signaling in Salvia miltiorrhiza
SmEIL1 transcription factor inhibits tanshinone accumulation in response to ethylene signaling in Salvia miltiorrhiza Open
Among the bioactive compounds, lipid-soluble tanshinone is present in Salvia miltiorrhiza , a medicinal plant species. While it is known that ethephon has the ability to inhibit the tanshinones biosynthesis in the S. miltiorrhiza hairy roo…
View article: Single-cell sequencing analysis and multiple machine-learning models revealed the cellular crosstalk of dendritic cells and identified FABP5 and KLRB1 as novel biomarkers for psoriasis
Single-cell sequencing analysis and multiple machine-learning models revealed the cellular crosstalk of dendritic cells and identified FABP5 and KLRB1 as novel biomarkers for psoriasis Open
Background Psoriasis is an immune-mediated disorder influenced by environmental factors on a genetic basis. Despite advancements, challenges persist, including the diminishing efficacy of biologics and small-molecule targeted agents, along…
View article: SPRR1B is Related to the Immune Microenvironment and Can Be Used as a Biomarker for the Diagnosis of Psoriasis
SPRR1B is Related to the Immune Microenvironment and Can Be Used as a Biomarker for the Diagnosis of Psoriasis Open
These findings suggest that SPRR1B may have a significant role in the pathogenesis of psoriasis and could be employed as a novel immunomarker for its development.
View article: Bioactive compounds and biological functions of medicinal plant-derived extracellular vesicles
Bioactive compounds and biological functions of medicinal plant-derived extracellular vesicles Open
Extracellular vesicles (EVs) are tiny lipid bilayer-enclosed membrane particles released from a variety of cell types into the surrounding environment. These EVs have massive participated in cell-to-cell communication and interspecies comm…
View article: Genome-wide identification and characterization of <i>Dof</i> gene family in <i>Salvia miltiorrhiza</i>
Genome-wide identification and characterization of <i>Dof</i> gene family in <i>Salvia miltiorrhiza</i> Open
Salvia miltiorrhiza is an important medicinal plant, and its main secondary metabolites are tanshinones and phenolic acids. Dof transcription factors play an irreplaceable role in regulating plant growth and secondary metabolism. However, …
View article: Chemical profiling and investigation of molecular mechanisms underlying anti-hepatocellular carcinoma activity of extracts from Polygonum perfoliatum L.
Chemical profiling and investigation of molecular mechanisms underlying anti-hepatocellular carcinoma activity of extracts from Polygonum perfoliatum L. Open
Polygonum perfoliatum L. is an herbal medicine that has been extensively used in traditional Chinese medicine to treat various health conditions ranging from ancient internal to surgical and gynecological diseases. Numerous studies suggest…
View article: Does each Component of Reactive Oxygen Species have a Dual Role inthe Tumor Microenvironment?
Does each Component of Reactive Oxygen Species have a Dual Role inthe Tumor Microenvironment? Open
: Reactive oxygen species (ROS) are a class of highly reactive oxidizing molecules, including superoxide anion (O2 •−) and hydrogen peroxide (H2O2), among others. Moderate levels of ROS play a crucial role in regulating cellular signaling …
View article: Unveiling the Dual Expression of Haptoglobin in Malignant Hepatocellular Carcinoma Cells through Single-Cell and Bulk RNA Sequencing Analysis
Unveiling the Dual Expression of Haptoglobin in Malignant Hepatocellular Carcinoma Cells through Single-Cell and Bulk RNA Sequencing Analysis Open
Hepatocellular carcinoma (HCC) is a highly prevalent and deadly cancer. Existing single-cell transcriptome research on HCC mainly focuses on immune and stromal cells, with limited analysis of malignant cell heterogeneity. In our study, we …
View article: Contribution of <scp>PGAP3</scp> co‐amplified and co‐overexpressed with <scp>ERBB2</scp> at 17q12 involved poor prognosis in gastric cancer
Contribution of <span>PGAP3</span> co‐amplified and co‐overexpressed with <span>ERBB2</span> at 17q12 involved poor prognosis in gastric cancer Open
The locus at 17q12 erb‐b2 receptor tyrosine kinase 2 (ERBB2) has been heavily amplificated and overexpressed in gastric cancer (GC), but it remains to be elucidated about the clinical significance of the co‐amplification and co‐overexpress…
View article: Research on Utility Calculation Method of Pumped Storage Participating in Peak-Shaving Market
Research on Utility Calculation Method of Pumped Storage Participating in Peak-Shaving Market Open
With the advancement of the “dual carbon” goal, the proportion of renewable energy in the system has increased significantly. The peak-shaving problem brought about by it has become increasingly significant. As an important flexible power …
View article: Reserve Demand Determination Method Considering the Different Time Periods Uncertainty of Wind and Solar
Reserve Demand Determination Method Considering the Different Time Periods Uncertainty of Wind and Solar Open
With the gradual realization of China’s 14th Five-Year Plan, the proportion of installed renewable energy capacity in all regions has increased significantly. The access of a high proportion of renewable energy has brought serious challeng…
View article: Study on NASH mouse model with different proportions of high-fat and high-sugar diets
Study on NASH mouse model with different proportions of high-fat and high-sugar diets Open
Nonalcoholic steatohepatitis (NASH) is characterized by varying degrees of steatosis, inflammatory and fibrotic changes. The pathophysiological mechanism of NASH is complex, and there is no rapid and effective method to establish Nash mode…
View article: Intercellular Communication Reveals Therapeutic Potential of Epithelial-Mesenchymal Transition in Triple-Negative Breast Cancer
Intercellular Communication Reveals Therapeutic Potential of Epithelial-Mesenchymal Transition in Triple-Negative Breast Cancer Open
(1) Background: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with high intra-tumoral heterogeneity. The epithelial-mesenchymal transition (EMT) is one of the inducers of cancer metastasis and migration. Ho…
View article: Assessment of Glucocorticoid Removal by UVA/Chlorination and Ozonation: Performance Comparison in Kinetics, Degradation Pathway, and Toxicity
Assessment of Glucocorticoid Removal by UVA/Chlorination and Ozonation: Performance Comparison in Kinetics, Degradation Pathway, and Toxicity Open
Glucocorticoids (GCs) have drawn great concern due to widespread contamination in the environment and application in treating COVID-19. This work aimed to compare the performance of UVA/chlorination and ozonation on GC removal in terms of …
View article: The potency of common proinflammatory cytokines measurement for revealing the risk and severity of anxiety and depression in psoriasis patients
The potency of common proinflammatory cytokines measurement for revealing the risk and severity of anxiety and depression in psoriasis patients Open
Objective Proinflammatory cytokines mediate anxiety and depression in various ways, such as immunity, inflammation, and the hypothalamic–pituitary–adrenal axis. This study intended to further explore the linkage of common proinflammatory c…
View article: GWAS of Chronic Spontaneous Urticaria Reveals Genetic Overlap with Autoimmune Diseases, Not Atopic Diseases
GWAS of Chronic Spontaneous Urticaria Reveals Genetic Overlap with Autoimmune Diseases, Not Atopic Diseases Open
View article: IgE and IgG Anti-Thyroid Autoantibodies in Chinese Patients With Chronic Spontaneous Urticaria and a Literature Review
IgE and IgG Anti-Thyroid Autoantibodies in Chinese Patients With Chronic Spontaneous Urticaria and a Literature Review Open
Immunoglobulin (Ig) E and IgG anti-thyroid autoantibodies (AAbs) play important roles in the immunopathogenesis of chronic spontaneous urticaria (CSU). To date, association of IgE and IgG AAbs with Chinese CSU patients has not been fully i…
View article: The impact of “4+7” volume based drugs procurement on the volume, expenditures, and daily costs of antihypertensive drugs in Shenzhen, China: a interrupted time series analysis
The impact of “4+7” volume based drugs procurement on the volume, expenditures, and daily costs of antihypertensive drugs in Shenzhen, China: a interrupted time series analysis Open
Background: On January 2019, Chinese government implemented the first round of the National Centralized Drug Procurement (NCDP) pilot of 25 drugs in 4 municipalities and 7 sub-provincial cities in mainland China, referred to as “4+7” polic…
View article: Association of HOTAIR Polymorphisms with Susceptibility to Psoriasis in a Chinese Han Population
Association of HOTAIR Polymorphisms with Susceptibility to Psoriasis in a Chinese Han Population Open
Psoriasis is a common disease in dermatology, but its etiology and pathogenesis have not been fully elucidated. In recent years, researchers have found that HOX transcript antisense RNA (HOTAIR) plays an important role in biological proces…
View article: Decoding Immune Heterogeneity of Melanoma and identifying immune-prognostic hub genes
Decoding Immune Heterogeneity of Melanoma and identifying immune-prognostic hub genes Open
Melanoma is an aggressive skin cancer that has gained attention worldwide. Growing evidence has highlighted that the tumor microenvironment (TME) is an important feature of carcinogenesis and contributes to therapeutic efficacy in melanoma…