Siyun Yang
YOU?
Author Swipe
View article: Medication stewardship by clinical pharmacists in acute ischemic stroke care: a retrospective analysis of drug-related problem reduction and cost-saving outcomes
Medication stewardship by clinical pharmacists in acute ischemic stroke care: a retrospective analysis of drug-related problem reduction and cost-saving outcomes Open
Background In China’s evolving Diagnosis-Intervention Packet (DIP) payment system, suboptimal medication practices in acute ischemic stroke (AIS) care exacerbate healthcare costs and antimicrobial resistance. This study evaluates the clini…
View article: Distribution patterns and evolution of antimicrobial resistance in Gram-negative bacteria within the intensive care unit of a tertiary hospital from 2019 to 2024
Distribution patterns and evolution of antimicrobial resistance in Gram-negative bacteria within the intensive care unit of a tertiary hospital from 2019 to 2024 Open
Background This study aims to investigate the distribution and drug resistance of Gram-negative bacteria in the intensive care unit (ICU) of a tertiary general hospital in Sichuan Province, with the goal of promoting rational antibiotic us…
View article: PEI-Reinforced GO/g-C<sub>3</sub>N<sub>4</sub> Composite Membrane for Salt Separation
PEI-Reinforced GO/g-C<sub>3</sub>N<sub>4</sub> Composite Membrane for Salt Separation Open
Membrane separation is an important separation and purification technology, membrane materials are the key to membrane separation technology, and the rapid development of two-dimensional materials in recent years has brought new opportunit…
View article: Screening and mechanistic study of natural compounds that enhance T cell anti-tumor effects post-heat treatment
Screening and mechanistic study of natural compounds that enhance T cell anti-tumor effects post-heat treatment Open
Introduction Following the approval of Chimeric Antigen Receptor T-cell Immunotherapy(CAR-T) in multiple countries, the Food and Drug Administration (FDA) approved tumor-infiltrating lymphocytes (TILs) and T-cell receptor-engineered T cell…
View article: AGTR1 potentiates the chemotherapeutic efficacy of cisplatin in esophageal carcinoma through elevation of intracellular Ca<sup>2+</sup> and induction of apoptosis
AGTR1 potentiates the chemotherapeutic efficacy of cisplatin in esophageal carcinoma through elevation of intracellular Ca<sup>2+</sup> and induction of apoptosis Open
Cisplatin is one of the principal chemotherapeutic agents used for esophageal cancer (EC) treatment; however, EC mortality remains high. It is therefore imperative to find new therapeutic targets and approaches to potentiate the chemothera…
View article: Efficacy and safety of biyuan tongqiao granules in the treatment of allergic rhinitis: A meta-analysis of randomized controlled trials
Efficacy and safety of biyuan tongqiao granules in the treatment of allergic rhinitis: A meta-analysis of randomized controlled trials Open
BYTQ granules with WM demonstrated superior efficacy in treating AR, including a lower recurrence rate based on the available results. Nonetheless, further RCTs are required to validate these results more conclusively.
View article: Clinical Assessment of Common Medications for Nonalcoholic Fatty Liver Disease: A Systematic Review and Bayesian Network Meta‐Analysis
Clinical Assessment of Common Medications for Nonalcoholic Fatty Liver Disease: A Systematic Review and Bayesian Network Meta‐Analysis Open
Objective With a steadily rising prevalence, nonalcoholic fatty liver disease (NAFLD) was a leading global cause of liver‐related health problems. In the clinical management of NAFLD, various western pharmaceuticals were widely utilized. T…
View article: Correction: Aidi injection inhibits the migration and invasion of gefitinib-resistant lung adenocarcinoma cells by regulating the PLAT/FAK/AKT pathway
Correction: Aidi injection inhibits the migration and invasion of gefitinib-resistant lung adenocarcinoma cells by regulating the PLAT/FAK/AKT pathway Open
View article: Exploring the Anti-Colorectal Cancer Mechanism of Norcantharidin Through TRAF5/NF-κB Pathway Regulation and Folate-Targeted Liposomal Delivery
Exploring the Anti-Colorectal Cancer Mechanism of Norcantharidin Through TRAF5/NF-κB Pathway Regulation and Folate-Targeted Liposomal Delivery Open
Colorectal cancer is one of the most common malignant tumors worldwide, significantly impacting human health. Cantharidin (CTD), an active compound derived from the Spanish fly, exhibits antitumor properties. Its derivative, norcantharidin…
View article: Aidi injection inhibits the migration and invasion of gefitinib-resistant lung adenocarcinoma cells by regulating the PLAT/FAK/AKT pathway
Aidi injection inhibits the migration and invasion of gefitinib-resistant lung adenocarcinoma cells by regulating the PLAT/FAK/AKT pathway Open
View article: The activity of dichloromethane extract of Tetradium ruticarpum (A.Juss.) T.G.Hartley against inflammatory bowel disease through modulating MAPK, VEGF, Apoptosis, and NLR signaling pathways
The activity of dichloromethane extract of Tetradium ruticarpum (A.Juss.) T.G.Hartley against inflammatory bowel disease through modulating MAPK, VEGF, Apoptosis, and NLR signaling pathways Open
View article: Chloride Ion Permeability Resistance of Ultra-high Performance Concrete with Iron Ore Tailings Based on Inter-pore Connection
Chloride Ion Permeability Resistance of Ultra-high Performance Concrete with Iron Ore Tailings Based on Inter-pore Connection Open
View article: Introducing third-generation periodic table descriptors for nano-qRASTR modeling of zebrafish toxicity of metal oxide nanoparticles
Introducing third-generation periodic table descriptors for nano-qRASTR modeling of zebrafish toxicity of metal oxide nanoparticles Open
Metal oxide nanoparticles (MONPs) are widely used in medicine and environmental remediation because of their unique properties. However, their size, surface area, and reactivity can cause toxicity, potentially leading to oxidative stress, …
View article: Effectiveness of Bairui granules in the treatment of respiratory tract infections: A systematic review and meta-analysis
Effectiveness of Bairui granules in the treatment of respiratory tract infections: A systematic review and meta-analysis Open
Background: Respiratory tract infections (RTIs) are characterized by a high mortality rate and clinical incidence. Bairui granules (BG), which employ a method of heat elimination and detoxification, have demonstrated benefits in the treatm…
View article: Investigation on the efficiency of lentinan for injection combining cisplatin on treating malignant pleural effusion based on systematic review and meta-analysis
Investigation on the efficiency of lentinan for injection combining cisplatin on treating malignant pleural effusion based on systematic review and meta-analysis Open
Background: Malignant pleural effusion (MPE) is a frequently observed complication in advanced malignant tumors. Clinical studies have shown that lentinan for injection (LNT) is beneficial for improving patients’ quality of life and prolon…
View article: Exploring the mechanism of action of Shuangyang houbitong granules in the treatment of acute pharyngitis based on network pharmacology and molecular docking
Exploring the mechanism of action of Shuangyang houbitong granules in the treatment of acute pharyngitis based on network pharmacology and molecular docking Open
Background: Acute pharyngitis (AP) refers to the acute inflammation of the pharynx, characterized by swelling and pain in the throat. Shuangyang houbitong granules (SHG), a traditional Chinese medicine compound, have been found to be effec…
View article: Protracted molecular dynamics and secondary structure introspection to identify dual-target inhibitors of Nipah virus exerting approved small molecules repurposing
Protracted molecular dynamics and secondary structure introspection to identify dual-target inhibitors of Nipah virus exerting approved small molecules repurposing Open
View article: Application of artificial intelligence and machine learning in early detection of adverse drug reactions (ADRs) and drug-induced toxicity
Application of artificial intelligence and machine learning in early detection of adverse drug reactions (ADRs) and drug-induced toxicity Open
Adverse drug reactions (ADRs) and drug-induced toxicity are major challenges in drug discovery, threatening patient safety and dramatically increasing healthcare expenditures. Since ADRs and toxicity are not as visible as infectious diseas…
View article: Dexamethasone for Inpatients With COVID-19 in a National Cohort
Dexamethasone for Inpatients With COVID-19 in a National Cohort Open
Importance Limited effective therapeutics are available to hospitalized patients with COVID-19. Clinical trials and observational studies have shown varying effects of systemic corticosteroids, including dexamethasone, in hospitalized pati…
View article: Are we ready to fight the Nipah virus pandemic? An overview of drug targets, current medications, and potential leads
Are we ready to fight the Nipah virus pandemic? An overview of drug targets, current medications, and potential leads Open
View article: AGTR1 potentiates the chemotherapeutic efficacy of Cisplatin in esophageal carcinoma through elevation of intracellular Ca 2+ and induction of apoptosis
AGTR1 potentiates the chemotherapeutic efficacy of Cisplatin in esophageal carcinoma through elevation of intracellular Ca 2+ and induction of apoptosis Open
Cisplatin is one of the principal chemotherapeutic agents used for esophageal cancer (EC) treatments, and EC mortality is still high. It is imperative to find new therapeutic targets and approaches to potentiate the chemotherapeutic effica…
View article: Systematic Review and Meta-Analysis on the Efficacy and Safety of Injectable Lentinan Combined with Chemotherapy in the Treatment of Gastric Cancer
Systematic Review and Meta-Analysis on the Efficacy and Safety of Injectable Lentinan Combined with Chemotherapy in the Treatment of Gastric Cancer Open
View article: Efficacy and Safety of Non-Steroidal Mineralocorticoid Receptor Antagonists in Patients With Chronic Kidney Disease and Type 2 Diabetes: A Systematic Review Incorporating an Indirect Comparisons Meta-Analysis
Efficacy and Safety of Non-Steroidal Mineralocorticoid Receptor Antagonists in Patients With Chronic Kidney Disease and Type 2 Diabetes: A Systematic Review Incorporating an Indirect Comparisons Meta-Analysis Open
Background: The non-steroidal mineralocorticoid receptor antagonists (MRAs) are promising treatments in patients with chronic kidney disease (CKD) and type 2 diabetes (T2D). We conducted a meta-analysis to explore the efficacy and safety o…
View article: Power Analysis for Cluster Randomized Trials with Continuous Coprimary Endpoints
Power Analysis for Cluster Randomized Trials with Continuous Coprimary Endpoints Open
Pragmatic trials evaluating health care interventions often adopt cluster randomization due to scientific or logistical considerations. Systematic reviews have shown that coprimary endpoints are not uncommon in pragmatic trials but are sel…
View article: Power analysis for cluster randomized trials with continuous co-primary endpoints
Power analysis for cluster randomized trials with continuous co-primary endpoints Open
Pragmatic trials evaluating health care interventions often adopt cluster randomization due to scientific or logistical considerations. Previous reviews have shown that co-primary endpoints are common in pragmatic trials but infrequently r…
View article: Completeness of reporting and risks of overstating impact in cluster randomised trials: a systematic review
Completeness of reporting and risks of overstating impact in cluster randomised trials: a systematic review Open
View article: Propensity score weighting for causal subgroup analysis
Propensity score weighting for causal subgroup analysis Open
A common goal in comparative effectiveness research is to estimate treatment effects on prespecified subpopulations of patients. Though widely used in medical research, causal inference methods for such subgroup analysis (SGA) remain under…
View article: Impact of Education and Data Feedback on Guideline-Concordant Prescribing for Urinary Tract Infections in the Outpatient Setting
Impact of Education and Data Feedback on Guideline-Concordant Prescribing for Urinary Tract Infections in the Outpatient Setting Open
Background Urinary tract infections (UTIs) are the most common outpatient indication for antibiotics and an important target for antimicrobial stewardship (AS) activities. With The Joint Commission standards now requiring outpatient AS, da…
View article: Covariate adjustment in subgroup analyses of randomized clinical trials: A propensity score approach
Covariate adjustment in subgroup analyses of randomized clinical trials: A propensity score approach Open
Background: Subgroup analyses are frequently conducted in randomized clinical trials to assess evidence of heterogeneous treatment effect across patient subpopulations. Although randomization balances covariates within subgroups in expecta…
View article: Radiological Society of North America/Quantitative Imaging Biomarker Alliance Shear Wave Speed Bias Quantification in Elastic and Viscoelastic Phantoms
Radiological Society of North America/Quantitative Imaging Biomarker Alliance Shear Wave Speed Bias Quantification in Elastic and Viscoelastic Phantoms Open
Objectives To quantify the bias of shear wave speed (SWS) measurements between different commercial ultrasonic shear elasticity systems and a magnetic resonance elastography (MRE) system in elastic and viscoelastic phantoms. Methods Two el…