Sjoerd H. E. van den Worm
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View article: Erratum: The RNA polymerase activity of SARS-coronavirus nsp12 is primer dependent
Erratum: The RNA polymerase activity of SARS-coronavirus nsp12 is primer dependent Open
The authors wish to apologise for an error in the concentration of tetracycline used to induce SARS-coronavirus nsp12 expression in E. coli. In the second paragraph of Materials and Methods, the sentence: “Subsequently, the cells were slow…
View article: The RNA polymerase activity of SARS-coronavirus nsp12 is primer dependent
The RNA polymerase activity of SARS-coronavirus nsp12 is primer dependent Open
An RNA-dependent RNA polymerase (RdRp) is the central catalytic subunit of the RNA-synthesizing machinery of all positive-strand RNA viruses. Usually, RdRp domains are readily identifiable by comparative sequence analysis, but biochemical …
View article: Zn2+ Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture
Zn2+ Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture Open
Increasing the intracellular Zn2+ concentration with zinc-ionophores like pyrithione (PT) can efficiently impair the replication of a variety of RNA viruses, including poliovirus and influenza virus. For some viruses this effect has been a…