Sk. Sarif Hassan
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View article: CpG-induced regions associated compositional stratification of human essential proteins through mathematical genomics
CpG-induced regions associated compositional stratification of human essential proteins through mathematical genomics Open
CpG islands are genomic regions enriched in cytosine–phosphate–guanine dinucleotides, typically associated with gene promoters and regulatory elements. While their role in transcriptional regulation is well established, their influence on …
View article: Structural and Biochemical Insights into CRISPR-Cas Nucleases for Therapeutic Genome Editing
Structural and Biochemical Insights into CRISPR-Cas Nucleases for Therapeutic Genome Editing Open
CRISPR-Cas nucleases have changed the world of genetic editing because they provides specific, programmable and scalable editing possibilities. These RNA-guided nucleases were first described in the adaptive immune systems of prokaryotes, …
View article: Study of Cytochrome B Gene Variations in Avian Fauna of Sargodha
Study of Cytochrome B Gene Variations in Avian Fauna of Sargodha Open
Pakistan is home to approximately 765 bird species, but molecular-level studies for species identification remain scarce. The Sargodha region, with its agricultural land, canal systems, and hilly terrain, provides ideal habitats for variou…
View article: Study of Cytochrome B Gene Variations in Avian Fauna of Sargodha
Study of Cytochrome B Gene Variations in Avian Fauna of Sargodha Open
Pakistan is home to approximately 765 bird species, but molecular-level studies for species identification remain scarce. The Sargodha region, with its agricultural land, canal systems, and hilly terrain, provides ideal habitats for variou…
View article: The XEC Variant: Genomic Evolution, Immune Evasion, and Public Health Implications
The XEC Variant: Genomic Evolution, Immune Evasion, and Public Health Implications Open
Narrative review synthesizes the most current literature on the SARS-CoV-2 XEC variant, focusing on its genomic evolution, immune evasion characteristics, epidemiological dynamics, and public health implications. To achieve this, we conduc…
View article: A Mathematical Genomics Perspective on the Moonlighting Role of Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH)
A Mathematical Genomics Perspective on the Moonlighting Role of Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) Open
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a well-conserved enzyme across Archaea, Bacteria, and Eukarya, known not only for its canonical role in glycolysis, but also for diverse moonlighting functions including transcription reg…
View article: The XEC Variant: Genomic Evolution, Immune Evasion, and Public Health Implications
The XEC Variant: Genomic Evolution, Immune Evasion, and Public Health Implications Open
The XEC strain of SARS-CoV-2 has drawn particular attention because of its ability to outcompete existing Omicron strains. Defined by distinctive spike protein mutations, T22N and Q493E, XEC exhibits increased ACE2 binding affinity and par…
View article: Proximal relationships of moonlighting Proteins in<i>Escherichia coli</i>: a mathematical genomic perspective
Proximal relationships of moonlighting Proteins in<i>Escherichia coli</i>: a mathematical genomic perspective Open
Moonlighting proteins in Escherichia coli ( E.coli ) perform multiple independent functions without altering their primary amino acid sequence, challenging the “one gene-one enzyme” hypothesis. Bacterial proteins serve various functions, i…
View article: Methuselah Proteins in Longevity: Unraveling Their Impact Through Mathematical Genomics
Methuselah Proteins in Longevity: Unraveling Their Impact Through Mathematical Genomics Open
This study provides a quantitative and comprehensive analysis of 18 Methuselah (mth) protein variants from fruit flies, focusing on their evolutionary relationships, structural features, and functional roles in aging and longevity. Phyloge…
View article: Unraveling potential gene biomarkers for dengue infection through RNA sequencing
Unraveling potential gene biomarkers for dengue infection through RNA sequencing Open
Dengue virus hijacks host cell mechanisms and immune responses in order to replicate efficiently. The interaction between the host and the virus affects the host's gene expression, which remains largely unexplored. This pilot study aimed t…
View article: Deciphering Depression: Epigenetic Mechanisms and Treatment Strategies
Deciphering Depression: Epigenetic Mechanisms and Treatment Strategies Open
Depression, a significant mental health disorder, is under intense research scrutiny to uncover its molecular foundations. Epigenetics, which focuses on controlling gene expression without altering DNA sequences, offers promising avenues f…
View article: Nanomaterial-Driven Precision Immunomodulation: A New Paradigm in Therapeutic Interventions
Nanomaterial-Driven Precision Immunomodulation: A New Paradigm in Therapeutic Interventions Open
Immunotherapy is a rapidly advancing field of research in the treatment of conditions such as cancer and autoimmunity. Nanomaterials can be designed for immune system manipulation, with precise targeted delivery and improved immunomodulato…
View article: Molecular Genomic Insights into Melanoma Associated Proteins PRAME and BAP1
Molecular Genomic Insights into Melanoma Associated Proteins PRAME and BAP1 Open
Background Melanoma, a worldwide widespread skin cancer with over 325,000 yearly incidences, demands a thorough understanding of its molecular components to create effective therapeutics. This study looks at the PRAME (cutaneous melanoma-a…
View article: SARS-CoV-2 NSP14 governs mutational instability and assists in making new SARS-CoV-2 variants
SARS-CoV-2 NSP14 governs mutational instability and assists in making new SARS-CoV-2 variants Open
View article: Molecular Genomic Insights into Melanoma Associated Proteins Prame and Bap1
Molecular Genomic Insights into Melanoma Associated Proteins Prame and Bap1 Open
View article: Unveiling the Genetic Tapestry: Rare Disease Genomics of Spinal Muscular Atrophy and Phenylketonuria Proteins
Unveiling the Genetic Tapestry: Rare Disease Genomics of Spinal Muscular Atrophy and Phenylketonuria Proteins Open
Rare diseases, defined by their low prevalence, present significant challenges, including delayed detection, expensive treatments, and limited research. This study delves into the genetic basis of two noteworthy rare diseases in Saudi Arab…
View article: The Distal-Proximal Relationships Among the Human Moonlighting Proteins: Evolutionary hotspots and Darwinian checkpoints
The Distal-Proximal Relationships Among the Human Moonlighting Proteins: Evolutionary hotspots and Darwinian checkpoints Open
Moonlighting proteins, known for their ability to perform multiple, often unrelated functions within a single polypeptide chain, challenge the traditional “one gene, one protein, one function” paradigm. As organisms evolved, their genomes …
View article: SARS-CoV-2 NSP14 governs mutational instability and assists in making new SARS-CoV-2 variants
SARS-CoV-2 NSP14 governs mutational instability and assists in making new SARS-CoV-2 variants Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the rapidly evolving RNA virus behind the COVID-19 pandemic, has spawned numerous variants since its 2019 emergence. The multifunctional NSP14 enzyme, possessing exonuclease and…
View article: Chen Circuit-Like Model: High Periodicity Leading to Chaotic Dynamics
Chen Circuit-Like Model: High Periodicity Leading to Chaotic Dynamics Open
The Chen circuit system, a three-dimensional autonomous system with intriguing dynamics, has gained considerable attention due to its potential applications in diverse scientific fields. In this article, a Chen circuit-like system is defin…
View article: Biology of Coital Behavior: Looking Through the Lens of Mathematical Genomics
Biology of Coital Behavior: Looking Through the Lens of Mathematical Genomics Open
Research has shown that genetics and epigenetics regulate mating behavior across multiple species. Previous studies have generally focused on the signaling pathways involved and spatial distribution of the associated receptors. However a t…
View article: Biology of Coital Behavior: Looking Through the Lens of Mathematical Genomics
Biology of Coital Behavior: Looking Through the Lens of Mathematical Genomics Open
Research has shown that genetics and epigenetics regulate mating behavior across multiple species. Previous studies have generally focused on the signaling pathways involved and spatial distribution of the associated receptors. However a t…
View article: Biology of Coital Behavior: Looking Through the Lens of Mathematical Genomics
Biology of Coital Behavior: Looking Through the Lens of Mathematical Genomics Open
Research has shown that genetics and epigenetics regulate mating behavior across multiple species. Previous studies have generally focused on the signaling pathways involved and spatial distribution of the associated receptors. However a t…
View article: COVID-19 signalome: Potential therapeutic interventions
COVID-19 signalome: Potential therapeutic interventions Open
The COVID-19 pandemic has triggered intensive research and development of drugs and vaccines against SARS-CoV-2 during the last two years. The major success was especially observed with development of vaccines based on viral vectors, nucle…
View article: Stability Chaos and Periodic Solution of Delayed Rational Recursive Sequence
Stability Chaos and Periodic Solution of Delayed Rational Recursive Sequence Open
In this paper, we will investigate a non-linear rational difference equation of higher order. Our concentration is on invariant intervals, periodic character, the character of semi cycles and global asymptotic stability of all positive sol…
View article: SARS-CoV-2 Variants Show a Gradual Declining Pathogenicity and Pro-Inflammatory Cytokine Stimulation, an Increasing Antigenic and Anti-Inflammatory Cytokine Induction, and Rising Structural Protein Instability: A Minimal Number Genome-Based Approach
SARS-CoV-2 Variants Show a Gradual Declining Pathogenicity and Pro-Inflammatory Cytokine Stimulation, an Increasing Antigenic and Anti-Inflammatory Cytokine Induction, and Rising Structural Protein Instability: A Minimal Number Genome-Based Approach Open
View article: Non-uniform aspects of the SARS-CoV-2 intraspecies evolution reopen question of its origin
Non-uniform aspects of the SARS-CoV-2 intraspecies evolution reopen question of its origin Open
View article: Possible Functional Proximity of Various Organisms Based on Taste Receptors Genomics
Possible Functional Proximity of Various Organisms Based on Taste Receptors Genomics Open
Taste is one of the essential senses in providing the organism a faithful representation of the external world. Taste perception is responsible for basic food and drink appraisal and bestows the organism with valuable discriminatory power.…
View article: Would New SARS-CoV-2 Variants Change the War against COVID-19?
Would New SARS-CoV-2 Variants Change the War against COVID-19? Open
The scientific, private, and industrial sectors use a wide variety of technological platforms available to achieve protection against SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), including vaccines. However, the virus evol…
View article: An issue of concern: unique truncated ORF8 protein variants of SARS-CoV-2
An issue of concern: unique truncated ORF8 protein variants of SARS-CoV-2 Open
Open reading frame 8 (ORF8) shows one of the highest levels of variability among accessory proteins in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the causative agent of Coronavirus Disease 2019 (COVID-19). It was previou…
View article: Would New SARS-CoV-2 Variants Change the War Against COVID-19?
Would New SARS-CoV-2 Variants Change the War Against COVID-19? Open
The scientific, private and industrial sectors use a wide variety of technological platforms available to achieve protection against SARS-CoV-2, including vaccines. However, the virus evolves continually into new highly virulent variants, …