Abraham Alexander
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View article: Pre-Treatment PET Radiomics for Prediction of Disease-Free Survival in Cervical Cancer
Pre-Treatment PET Radiomics for Prediction of Disease-Free Survival in Cervical Cancer Open
Background: Cervical cancer remains a major global health concern, with high recurrence rates in advanced stages. [18F]FDG PET/CT provides prognostic biomarkers such as SUV, MTV, and TLG, though these are not routinely integrated into clin…
View article: Lateral and air-water inorganic carbon and methane fluxes in a small Arctic river: Seasonal variations and the connections with local hydrology
Lateral and air-water inorganic carbon and methane fluxes in a small Arctic river: Seasonal variations and the connections with local hydrology Open
The importance of rivers to the global carbon cycle is well recognized, and the need for more measurements from historically understudied systems including Arctic rivers is essential in reducing bias. The proximity of Freshwater Creek to t…
View article: Using deep learning generated CBCT contours for online dose assessment of prostate SABR treatments
Using deep learning generated CBCT contours for online dose assessment of prostate SABR treatments Open
Prostate Stereotactic Ablative Body Radiotherapy (SABR) is an ultra‐hypofractionated treatment where small setup errors can lead to higher doses to organs at risk (OARs). Although bowel and bladder preparation protocols reduce inter‐fracti…
View article: Treatment With Stereotactic Ablative Radiotherapy for Up to 5 Oligometastases in Patients With Cancer
Treatment With Stereotactic Ablative Radiotherapy for Up to 5 Oligometastases in Patients With Cancer Open
Importance After the publication of the landmark SABR-COMET trial, concerns arose regarding high-grade toxic effects of treatment with stereotactic ablative body radiotherapy (SABR) for oligometastases. Objective To document toxic effects …
View article: Potential of Gold Nanoparticles in Current Radiotherapy Using a Co-Culture Model of Cancer Cells and Cancer Associated Fibroblasts
Potential of Gold Nanoparticles in Current Radiotherapy Using a Co-Culture Model of Cancer Cells and Cancer Associated Fibroblasts Open
Many cancer therapeutics are tested in vitro using only tumour cells. However, the tumour promoting effect of cancer associated fibroblasts (CAFs) within the tumour microenvironment (TME) is thought to reduce cancer therapeutics’ efficacy.…
View article: Population Based Phase II Trial of Stereotactic Ablative Radiotherapy (SABR) for up to 5 Oligometastases: Preliminary Results of the SABR-5 Trial
Population Based Phase II Trial of Stereotactic Ablative Radiotherapy (SABR) for up to 5 Oligometastases: Preliminary Results of the SABR-5 Trial Open
View article: Implementation of deep learning-based auto-segmentation for radiotherapy planning structures: a workflow study at two cancer centers
Implementation of deep learning-based auto-segmentation for radiotherapy planning structures: a workflow study at two cancer centers Open
View article: Investigation of Nano-Bio Interactions within a Pancreatic Tumor Microenvironment for the Advancement of Nanomedicine in Cancer Treatment
Investigation of Nano-Bio Interactions within a Pancreatic Tumor Microenvironment for the Advancement of Nanomedicine in Cancer Treatment Open
Pancreatic cancer is one of the deadliest types of cancer, with a five-year survival rate of only 10%. Nanotechnology offers a novel perspective to treat such deadly cancers through their incorporation into radiotherapy and chemotherapy. H…
View article: 25: Implementation of Deep Learning-Based Auto-Segmentation for Radiotherapy Planning Structures: A Multi-Center Workflow Study
25: Implementation of Deep Learning-Based Auto-Segmentation for Radiotherapy Planning Structures: A Multi-Center Workflow Study Open
View article: SpaceOAR© hydrogel rectal dose reduction prediction model: a decision support tool
SpaceOAR© hydrogel rectal dose reduction prediction model: a decision support tool Open
Prostate cancer external beam radiation therapy can result in toxicity due to organ at risk (OAR) dose, potentially impairing quality of life. A polyethylene glycol‐based spacer, SpaceOAR© hydrogel (SOH), implanted between prostate gland a…
View article: Comparing Deep Learning-based Auto-segmentation of Organs at Risk and Clinical Target Volumes to Expert Inter-Observer Variability in Radiotherapy Planning
Comparing Deep Learning-based Auto-segmentation of Organs at Risk and Clinical Target Volumes to Expert Inter-Observer Variability in Radiotherapy Planning Open
View article: OC-0530 Improving OAR volumes during prostate RT using daily patient feedback and standardized protocols
OC-0530 Improving OAR volumes during prostate RT using daily patient feedback and standardized protocols Open
View article: Maximizing rectal dose sparing with hydrogel: A retrospective planning study
Maximizing rectal dose sparing with hydrogel: A retrospective planning study Open
External beam radiation therapy for prostate cancer can result in urinary, sexual, and rectal side effects, often impairing quality of life. A polyethylene glycol‐based product, SpaceOAR© hydrogel ( SOH ), implanted into the connective tis…
View article: Pain response in a population-based study of radium-223 (Ra223) for metastatic castration-resistant prostate cancer
Pain response in a population-based study of radium-223 (Ra223) for metastatic castration-resistant prostate cancer Open
Introduction: Clinical trials have shown that radium-223 (Ra223) can prolong survival and improve quality of life in patients with metastatic castration-resistant prostate cancer (mCRPC). The objectives of this study were to evaluate pain …
View article: Subventricular Zone Radiation Dose and Outcome for Glioblastoma Treated Between 2006 and 2012
Subventricular Zone Radiation Dose and Outcome for Glioblastoma Treated Between 2006 and 2012 Open
View article: A population-based study of the use of radium 223 in metastatic castration-resistant prostate cancer: Factors associated with treatment completion
A population-based study of the use of radium 223 in metastatic castration-resistant prostate cancer: Factors associated with treatment completion Open
Introduction: Radium 223 (Ra223) given for six cycles has proven efficacy in clinical trials, but its population-level generalizability has not been well-described. The objectives of this study were to describe population-based Ra223 use i…
View article: Immune Modulation by Androgen Deprivation and Radiation Therapy: Implications for Prostate Cancer Immunotherapy
Immune Modulation by Androgen Deprivation and Radiation Therapy: Implications for Prostate Cancer Immunotherapy Open
Prostate cancer patients often receive androgen deprivation therapy (ADT) in combination with radiation therapy (RT). Recent evidence suggests that both ADT and RT have immune modulatory properties. First, ADT can cause infiltration of lymp…