Skylar S. Wright
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View article: Endolysosomal damage surveillance enables rapid inflammasome sensing of pathogens
Endolysosomal damage surveillance enables rapid inflammasome sensing of pathogens Open
Host cell cytosol is monitored by inflammasomes. Cytosolic invasion of pathogens involves breaching endolysosomal membranes, which is sensed by galectins triggering endolysosomal damage response. Whether and how endomembrane damage surveil…
View article: A bacterial toxin co-opts caspase-3 to disable active gasdermin D and limit macrophage pyroptosis
A bacterial toxin co-opts caspase-3 to disable active gasdermin D and limit macrophage pyroptosis Open
View article: Role of Extracellular Vesicles in Immunity and Host Defense
Role of Extracellular Vesicles in Immunity and Host Defense Open
Extracellular vesicles (EVs) are membrane-bound structures released by cells and have become significant players in immune system functioning, primarily by facilitating cell-to-cell communication. Immune cells like neutrophils and dendriti…
View article: Structural Variations in Circulating Lipopolysaccharide May Be Associated with Extended Stress in the Heat
Structural Variations in Circulating Lipopolysaccharide May Be Associated with Extended Stress in the Heat Open
View article: Host extracellular vesicles confer cytosolic access to systemic LPS licensing non-canonical inflammasome sensing and pyroptosis
Host extracellular vesicles confer cytosolic access to systemic LPS licensing non-canonical inflammasome sensing and pyroptosis Open
View article: A bacterial autotransporter impairs innate immune responses by targeting the transcription factor TFE3
A bacterial autotransporter impairs innate immune responses by targeting the transcription factor TFE3 Open
Type I interferons (IFNs) are consequential cytokines in antibacterial defense. Whether and how bacterial pathogens inhibit innate immune receptor-driven type I IFN expression remains mostly unknown. By screening a library of enterohemorrh…
View article: Structural basis for GSDMB pore formation and its targeting by IpaH7.8
Structural basis for GSDMB pore formation and its targeting by IpaH7.8 Open
View article: Mechanisms and Consequences of Noncanonical Inflammasome-Mediated Pyroptosis
Mechanisms and Consequences of Noncanonical Inflammasome-Mediated Pyroptosis Open
View article: Hierarchical cell-type-specific functions of caspase-11 in LPS shock and antibacterial host defense
Hierarchical cell-type-specific functions of caspase-11 in LPS shock and antibacterial host defense Open
View article: Impact of Nutrient Intake on Hydration Biomarkers Following Exercise and Rehydration Using a Clustering-Based Approach
Impact of Nutrient Intake on Hydration Biomarkers Following Exercise and Rehydration Using a Clustering-Based Approach Open
We investigated the impact of nutrient intake on hydration biomarkers in cyclists before and after a 161 km ride, including one hour after a 650 mL water bolus consumed post-ride. To control for multicollinearity, we chose a clustering-bas…
View article: Structural Variations in Circulating Lipopolysaccharide may Increase Severity of Exercise-Induced Heat Illness
Structural Variations in Circulating Lipopolysaccharide may Increase Severity of Exercise-Induced Heat Illness Open
Previous investigations at the Falmouth Road Race (FRR; Falmouth, MA) suggest that combined exercise, heat, and dehydration stress increase circulating lipopolysaccharide, associated binding proteins, and downstream immune signaling. Lipop…