S. Schrier
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Lenalidomide, melphalan and dexamethasone in a population of patients with immunoglobulin light chain amyloidosis with high rates of advanced cardiac involvement Open
Immunoglobulin light chain amyloidosis remains incurable despite recent therapeutic advances, and is particularly difficult to treat in patients with amyloid cardiomyopathy. Based on evidence of activity in multiple myeloma, we designed a …
Removal of erythrocyte membrane iron in vivo ameliorates the pathobiology of murine thalassemia. Open
Abnormal deposits of free iron are found on the cytoplasmic surface of red blood cell (RBC) membranes in beta-thalassemia. To test the hypothesis that this is of importance to RBC pathobiology, we administered the iron chelator deferiprone…
The Unusual Pathobiology of Hemoglobin Constant Spring Red Blood Cells Open
Hemoglobin Constant Spring (HbCS) is the most common nondeletional α-thalassemic mutation and is an important cause of HbH-like disease in Southeast Asia. HbCS variants have an almost normal mean cell volume (MCV) and the anemia is more se…
The Unusual Pathobiology of Hemoglobin Constant Spring Red Blood Cells Open
Hemoglobin Constant Spring (HbCS) is the most common nondeletional α-thalassemic mutation and is an important cause of HbH-like disease in Southeast Asia. HbCS variants have an almost normal mean cell volume (MCV) and the anemia is more se…
Abnormal assembly of membrane proteins in erythroid progenitors of patients with beta-thalassemia major Open
The life threatening anemia in beta-thalassemia major (Cooley's anemia) is characterized by profound intramedullary lysis, the cause of which is incompletely understood. Using marrow obtained from beta thalassemia major patients undergoing…
Studies on the effect of vanadate on endocytosis and shape changes in human red blood cells and ghosts Open
When amphipathic cationic drugs are added to intact human RBCs, the RBCs first undergo a stomatocytic shape change and then, if relatively large amounts of drug are added and if the metabolic state of the RBC is appropriate, endocytic vacu…
Spectrin rearrangement early in erythrocyte ghost endocytosis. Open
The endocytic vacuoles induced in white ghosts were found to be depleted of spectrin and therefore it was proposed that they arose from spectrin-free areas in the erythrocyte membrane. To follow changes in spectrin distribution during endo…
Aspirin-Persantin Prophylaxis in Elective total hip Replacement Open
A prospective, double-blind clinical study was performed to evaluate the combination of dipyridamole(Persantin)225 mg/day and acetyl salicyclic acid (ASA) 1 g/day prophylaxis of post-operative venous thromboembolism in elective total hip r…
Physical characteristics of nonimmunologic adherence of IgG to RBC ghost membranes. Open
These studies were undertaken with the aim of detecting possible differences between immunologic binding of IgG antibodies to erythrocyte membranes and the well documented nonimmunologic adherence to erythrocytes of large numbers of IgG mo…