Explanipedia

Use of a very low carbohydrate diet for prediabetes and type 2 diabetes: An audit Open

Mariela Glandt, Nir Y. Ailon, Slava Berger, David Unwin · 2024

Background: Type 2 diabetes (T2D) is viewed as a progressive chronic condition, yet recent research has raised hopes for reversal of this trajectory through innovative approaches. Aim: This audit assessed the impact of a very low carbohydr…

Leptin-loaded Extracellular Vesicles Treat Sleep-disordered Breathing in Mice with Obesity Open

Carla Freire, Jacob D. Ramsey, Huy Pho, Ryo Kojima, Yuling Zhao , et al. · 2022

Sleep-disordered breathing (SDB), obstructive sleep apnea, and obesity hypoventilation are highly prevalent in obesity and have no effective pharmacotherapy. Leptin is a powerful stimulant of ventilatory control and upper airway patency du…

Leptin-loaded Extracellular Vesicles Treat Sleep-disordered Breathing in Mice with Obesity Open

Carla Freire, Jacob D. Ramsey, Huy Pho, Ryo Kojima, Yuling Zhao , et al. · 2022

003 Treatment of Sleep Disordered Breathing with Leptin Loaded Exosomes Open

Carla Freire, Huy Pho, Jacob D. Ramsey, Stone R. Streeter, Ryo Kojima , et al. · 2021

Introduction Obstructive sleep apnea (OSA) is characterized by recurrent periods of upper airway obstruction. The prevalence of OSA exceeds 50% in obese individuals and in 10–20% of obese patients OSA coexists with obesity hypoventilation …

Leptin receptor expression in the dorsomedial hypothalamus stimulates breathing during NREM sleep in db/db mice Open

Huy Pho, Slava Berger, Carla Freire, Lenise Jihe Kim, Mi-Kyung Shin , et al. · 2021

Study Objectives Obesity leads to obstructive sleep apnea (OSA), which is recurrent upper airway obstruction during sleep, and obesity hypoventilation syndrome (OHS), hypoventilation during sleep resulting in daytime hypercapnia. Impaired …

Leptin receptor expression in the dorsomedial hypothalamus stimulates breathing during NREM sleep indb/dbmice Open

Huy Pho, Slava Berger, Carla Freire, Lenise Jihe Kim, Mi‐Kyung Shin , et al. · 2020

Obesity can lead to recurrent upper airway obstruction (obstructive sleep apnea, OSA) during sleep as well as alveolar hypoventilation. We have previously shown that leptin stimulates breathing and treats OSA in leptin-deficient ob/ob mice…

0073 Activation of Leptin Receptor Positive Neurons in the Nucleus of The Solitary Tract (NTS) Alleviates Sleep Disordered Breathing in Obese Mice Open

Carla Freire, Huy Pho, Slava Berger, Thomaz Fleury Curado, Luiz Ubirajara Sennes , et al. · 2019

Obstructive Sleep Apnea (OSA) is a major cause of morbidity and mortality with high prevalence. The loss of motor input related to deeper sleep stages lead to recurrent pharyngeal collapse (apneas and hypopneas), leading to oxyhemoglobin d…

0002 Leptin Receptor Positive Neurons In The Dorsomedial Hypothalamus Maintain Upper Airway Patency During Sleep Open

Huy Pho, Slava Berger, Carla Freire, Olga Dergacheva, Thomaz Fleury Curado , et al. · 2019

Introduction: Noradrenergic (NA) neurons of A7 and SubCoeruleus (SubC) pontine nuclei project to the hypoglossal (XII) nucleus and provide excitatory input to XII motoneurons that play a role in the pathology of obstructive sleep apnea (OS…

Caloric restriction prevents the development of airway hyperresponsiveness in mice on a high fat diet Open

Haris Younas, Marcela Gabriela Feitosa Vieira, Chenjuan Gu, Rachel Lee, Mi-Kyung Shin , et al. · 2019

Pharmacotherapy of Obstructive Sleep Apnea: Is Salvation Just Around a Corner? Open

Thomaz Fleury Curado, Slava Berger, Vsevolod Y. Polotsky · 2018

Silencing of Hypoglossal Motoneurons Leads to Sleep Disordered Breathing in Lean Mice Open

Thomaz Fleury Curado, Huy Pho, Olga Dergacheva, Slava Berger, Rachel Lee , et al. · 2018

Obstructive Sleep Apnea (OSA) is a prevalent condition and a major cause of morbidity and mortality in Western Society. The loss of motor input to the tongue and specifically to the genioglossus muscle during sleep is associated with phary…

Leptin acts in the carotid bodies to increase minute ventilation during wakefulness and sleep and augment the hypoxic ventilatory response Open

Candela Caballero‐Eraso, Mi‐Kyung Shin, Huy Pho, Lenise Jihe Kim, Luis E. Pichard , et al. · 2018

Key points Leptin is a potent respiratory stimulant. A long functional isoform of leptin receptor, LepR b , was detected in the carotid body (CB), a key peripheral hypoxia sensor. However, the effect of leptin on minute ventilation ( V E )…

Liver Enlargement Predicts Obstructive Sleep Apnea–Hypopnea Syndrome in Morbidly Obese Women Open

Giovanna Scartabelli, Giorgia Querci, Letizia Marconi, Giovanni Ceccarini, Paolo Piaggi , et al. · 2018

Obstructive sleep apnea-hypopnea syndrome (OSAHS) is frequently present in patients with severe obesity, but its prevalence especially in women is not well defined. OSAHS and non-alcoholic fatty liver disease are common conditions, frequen…

Sleep-disordered breathing in C57BL/6J mice with diet-induced obesity Open

Thomaz Fleury Curado, Huy Pho, Slava Berger, Candela Caballero‐Eraso, Mi-Kyung Shin , et al. · 2018

Obesity leads to sleep-disordered breathing (SDB) manifested by recurrent upper airway obstructions termed obstructive sleep apnea (OSA) and carbon dioxide retention due to hypoventilation. The objective of this work was to characterize br…

High fat diet induces airway hyperresponsiveness in mice Open

Kathrin Fricke, Marcela Gabriela Feitosa Vieira, Haris Younas, Mi-Kyung Shin, Shannon Bevans‐Fonti , et al. · 2018

0077 Intranasal Leptin Approach To Treat Sleep-disordered Breathing Open

Slava Berger, Huy Pho, Thomaz Fleury Curado, Alan R. Schwartz, Vsevolod Y. Polotsky · 2018

Sleep-Disordered Breathing (SDB) is a group of disorders characterized by recurrent upper airway obstructions and/or hypoventilation during sleep. SDB is highly prevalent in the obese population and is associated with increased cardiovascu…

0067 Chemogenetic Silencing of Hypoglossal Motor Neurons Creates a Model of Upper Airway Obstruction During Sleep Open

T A Fleury Curado, Huy Pho, Slava Berger, Rachel Siying Lee, Luiz Ubirajara Sennes , et al. · 2018

Obstructive Sleep Apnea (OSA) is a prevalent condition and a major cause of morbidity and mortality in Western Society. OSA contributes significantly to the development and progression of neurocognitive, metabolic, cardiovascular, and onco…

0133 Leptin Signaling In Dorsal Medial Hypothalamus Regulates Upper Airway Patency And Reverses Sleep Disordered Breathing In Leptin-resistant Db/db Mice Open

Huy Pho, Slava Berger, Thomaz Fleury Curado, Alan R. Schwartz, Vsevolod Y. Polotsky · 2018

Severe obesity leads to more prevalent obstructive sleep apnea (OSA), recurrent obstruction of the upper airway during sleep, and obesity hypoventilation syndrome (OHS) caused by impaired central nervous system responses to CO2. Our group …

Disturbed sleep and diabetes: A potential nexus of dementia risk Open

Calliope Holingue, Alexandra Wennberg, Slava Berger, Vsevolod Y. Polotsky, Adam P. Spira · 2018

Leptin and Leptin Resistance in the Pathogenesis of Obstructive Sleep Apnea: A Possible Link to Oxidative Stress and Cardiovascular Complications Open

Slava Berger, Vsevolod Y. Polotsky · 2018

Obesity‐related sleep breathing disorders such as obstructive sleep apnea (OSA) and obesity hypoventilation syndrome (OHS) cause intermittent hypoxia (IH) during sleep, a powerful trigger of oxidative stress. Obesity also leads to dramatic…

Intermittent Hypoxia Affects the Spontaneous Differentiation In Vitro of Human Neutrophils into Long‐Lived Giant Phagocytes Open

Larissa Dyugovskaya, Slava Berger, А. P. Polyakov, Peretz Lavie, Lena Lavie · 2015

Previously we identified, for the first time, a new small‐size subset of neutrophil‐derived giant phagocytes (G ϕ ) which spontaneously develop in vitro without additional growth factors or cytokines. G ϕ are CD66b + /CD63 + /MPO + /LC3B +…

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